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Evaluation of Small Biopsy Material in Patients with Multiple and Secondary Tumors

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Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology

Abstract

In clinical scenarios involving multiple pulmonary nodules, small biopsies and cytology specimens are frequently utilized to determine if the lesions represent a primary lung tumor with intrapulmonary metastases, multiple independent primary pulmonary tumors, metastatic tumors from an extrapulmonary origin, or a nonneoplastic process. In cases of tumors, ancillary studies can be successfully performed on small biopsy and cytology specimens to determine the etiology. It is important to characterize these tumors systematically in this era of personalized medicine. This entails meticulous examination of the morphology, use of limited immunopanels in a staged approach, and triage of slides upfront for potential molecular studies to maximize the information obtainable from these small specimens. This chapter will focus on the application of clinical considerations, morphology, and ancillary studies on small specimens from patients with multiple and/or secondary pulmonary tumors.

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Ave. POB2, Suite 201, Pittsburgh, PA, 15232, USA

    Sara E. Monaco M.D.

  2. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Sanja Dacic M.D, Ph.D.

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  1. Sara E. Monaco M.D.
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Correspondence to Sara E. Monaco M.D. .

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  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Andre Luis Moreira

  2. Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, New York, USA

    Anjali Saqi

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Monaco, S.E., Dacic, S. (2015). Evaluation of Small Biopsy Material in Patients with Multiple and Secondary Tumors. In: Moreira, A., Saqi, A. (eds) Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1607-8_9

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