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Clinical Significance of 2,3-Diphosphoglycerate in Hematology

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The Year in Hematology

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Abstract

A decade has now elapsed since the observations of Chanutin and Curnish (1967) and Benesch and Benesch (1967) that intraerythrocytic organic phosphates play a central role in modulating hemoglobin’s affinity for oxygen. In the ensuing years many clinical conditions have been identified in which the position of the oxygen-hemoglobin equilibrium curve has deviated from normal as a result of variations in the concentration of red cell organic phosphates. Numerous studies have been performed in both animals and man in an attempt to elucidate the significance of these deviations in terms of oxygen delivery. Much of the data are highly suggestive but as yet it remains unclear just how important a shift in the oxygen-hemoglobin equilibrium curve is in the adaptation of man to both physiologic and pathologic processes.

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  1. Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York, USA

    Frank A. Oski & Julia A. McMillan

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  1. Graduate School of Arts and Science, New York University, New York, New York, USA

    Albert S. Gordon Ph.D., F.R.S.M.  & Joseph LoBue Ph.D.  & 

  2. New York University School of Medicine, New York, New York, USA

    Robert Silber M.D.

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Oski, F.A., McMillan, J.A. (1977). Clinical Significance of 2,3-Diphosphoglycerate in Hematology. In: Gordon, A.S., Silber, R., LoBue, J. (eds) The Year in Hematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6688-9_3

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