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Disorders with Excessive Muscle Contraction: Candidates for Treatment with Intramuscular Botulinum Toxin (“Botox”)

  • Chapter
Botulinum and Tetanus Neurotoxins

Abstract

The initial clinical use of local injections of type A botulinum toxin (botox) was for the treatment of strabismus.1 The intended goal was to block acetylcholinergic neuromuscular junctions and rebalance neural input to the extraocular rectus muscles; this enhanced convergence.2 Several drugs, including alpha-bungarotoxin, had been considered prior to botox, but each had limitations. These included lack of selectivity, undesired side effects, short duration of action, and substantial antigenicity. Botox has the advantage of being apotent neuromuscular blocking agent while not suffering as many limitations as other putative therapeutic agents.

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Authors and Affiliations

  1. Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA

    Mitchell F. Brin, Celia Stewart & James Miller

  2. Otolaryngology, Columbia Presbyterian Medical Center, New York, NY, USA

    Andrew Blitzer & Celia Stewart

  3. Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA

    Zachary Pine

  4. Department of Rehabilitation Medicine, Tufts University, Boston, MA, USA

    Joanne Borg-Stein

  5. Stuttering Center Speech Motor-Control Laboratory, Department of Neurology, Baylor College of Medicine & the Methodist Hospital, Houston, Texas, USA

    Nagalapura S. Viswanath & David B. Rosenfield

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  1. Mitchell F. Brin
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  1. University of Wisconsin, Madison, Wisconsin, USA

    Bibhuti R. DasGupta

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© 1993 Springer Science+Business Media New York

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Brin, M.F. et al. (1993). Disorders with Excessive Muscle Contraction: Candidates for Treatment with Intramuscular Botulinum Toxin (“Botox”). In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_62

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  • DOI: https://doi.org/10.1007/978-1-4757-9542-4_62

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9544-8

  • Online ISBN: 978-1-4757-9542-4

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