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C-MYC: Oncogene and Tumour Suppressor Gene

  • Chapter
Apoptosis

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 5))

Abstract

Eukaryotic cell proliferation in metazoans is regulated by a variety of positive and negative signals that serve to rigidly control cell division. This underscores a major problem facing multicellular organisms: namely, how to allow the rapid proliferation of component cells and at the same time never allow those component cells to engage in competition with each other. In principle, any cell that acquires a growth advantage through mutation should out-compete its siblings and generate a hyperplastic clone from which ever more rapidly proliferating mutants are likely to arise. Such an event is, however, extremely rare as demonstrated by the fact that cancer arises in only one in three individuals during the entire course of their lives. Part of the answer to this paradox appears to reside in the multifunctional nature of the components that mediate cell proliferation. One of these, c-Myc, is the subject of this paper.

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Author information

Authors and Affiliations

  1. Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, P.O. Box 123, Lincoln’s Inn Fields, London, WC2A 3PX, UK

    Gerard Evan, Trevor Littlewood, David Hancock, Martin Bennett, Elizabeth Harrington & Abdallah Fanidi

Authors
  1. Gerard Evan
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  2. Trevor Littlewood
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  3. David Hancock
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  4. Martin Bennett
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  5. Elizabeth Harrington
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  6. Abdallah Fanidi
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Editor information

Editors and Affiliations

  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. Stanford University, Stanford, California, USA

    Robert T. Schimke

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© 1994 Springer Science+Business Media New York

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Evan, G., Littlewood, T., Hancock, D., Bennett, M., Harrington, E., Fanidi, A. (1994). C-MYC: Oncogene and Tumour Suppressor Gene. In: Mihich, E., Schimke, R.T. (eds) Apoptosis. Pezcoller Foundation Symposia, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9217-1_5

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  • DOI: https://doi.org/10.1007/978-1-4757-9217-1_5

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4757-9217-1

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