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In Vitro Studies of Oligodendroglial Lipid Metabolism

  • Chapter
Oligodendroglia

Part of the book series: Advances in Neurochemistry ((ANCH,volume 5))

Abstract

The only known function of oligodendroglia at present is to myelinate axons in the CNS. Myelin is a lipid-rich oligodendroglial plasma-membrane derivative containing galactolipids, cholesterol, and phospholipids in a molar ratio of about 1:2:2. In vivo studies have established the normal sequences of oligodendroglial maturation and myelination and have identified diseases in which initial CNS myelination is not carried to completion, such as phenylketonuria (PKU) and Krabbe’s disease, or in which normally myelinated CNS becomes demyelinated, such as multiple sclerosis (MS). Identification of the special metabolic characteristics of oligodendroglia that facilitate and regulate myelin synthesis and myelin maintenance will lead to a better understanding of the pathogenesis of dysmyelinative and demyelinative diseases.

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Authors and Affiliations

  1. Children’s Hospital of Philadelphia and Departments of Neurology and Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    David Pleasure & Donald H. Silberberg

  2. Division of Neurology, University of British Columbia, Vancouver, B. C., V6T 1W5, Canada

    Seung U. Kim

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  1. David Pleasure
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  1. Albert Einstein College of Medicine, Bronx, New York, USA

    William T. Norton

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Pleasure, D., Kim, S.U., Silberberg, D.H. (1984). In Vitro Studies of Oligodendroglial Lipid Metabolism. In: Norton, W.T. (eds) Oligodendroglia. Advances in Neurochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6066-8_5

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