Skip to main content

Sandoz Lecture Migraine—A Biochemical Disorder?

  • Chapter
Background to Migraine
  • 46 Accesses

Abstract

The Sandoz Lectures given thus far have been devoted to an historical survey by one of the originators of the Migraine Trust, to aspects of pharmacology in relation to migraine by an acknowledged expert, and to a clinical review by one of America’s foremost clinicians. All three have been founded on fact together with personal observations; now, however, it has been suggested that biochemical features be the subject of the Lecture. This opens the field for speculation, for there are few undoubted facts available.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anthony, M., Hinterberger, H. and Lance, J. W. (1967). Plasma serotonin in migraine and stress. Arch. Neurol., Chicago, 16, 544–552.

    Article  Google Scholar 

  • Anthony, M. and Lance, J. W. (1969). Monoamine oxidase inhibition in the treatment of migraine. Arch. Neurol., Chicago, 21, 263–268.

    Article  Google Scholar 

  • Blau, J. N., Horsfield, D., Quick, J. and Cumings, J. N. (1967). The production of migraine and biochemical changes in induced attacks. In Background to Migraine, page 146. London: William Heinemann Medical Books.

    Google Scholar 

  • Brodie, B. B., Maickel, R. P. and Westermann, E. O. (1961). Action of reserpine on pituitary-adrenocortical system through possible action on hypothalamus. In Regional Neurochemistry, Physiology and Pharmacology of the Nervous System. Proceedings of the Fourth International Neurochemical Symposium, Italy, page 351. Oxford: Pergamon Press.

    Google Scholar 

  • Campbell, Dorothy A., Hay, E. M. and Tonks, Eva M. (1951). An investigation of the salt and water balance in migraine. Brit. med. J. 2, 1424–1429.

    Article  Google Scholar 

  • Curran, D. A., Hinterberger, H. and Lance, J. W. (1965). Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxymethoxymandelic acid excretion in normal and migrainous subjects. Brain, 88, 997–1010.

    Article  Google Scholar 

  • Curzon, G., Barrie, M. and Wilkinson, M. I. P. (1969). Relationship between headache and amine changes after administration of reserpine to migrainous patients. J. Neurol. Neurosurg. Psychiat. 32, 555–561.

    Article  Google Scholar 

  • Curzon, G., Theaker, Prunella and Phillips, B. (1966). Excretion of 5-hydroxyindolyl acetic acid (5-HIAA) in migraine. J. Neurol. Neurosurg. Psychiat. 29, 85–90.

    Article  Google Scholar 

  • da Prada, M. and Pletscher, A. (1970). Mechanisms of uptake, storage and release of 5-hydroxytryptamine in blood platelets. Proceedings of International Migraine-Headache Symposium, Florence, page 101, World Federation of Neurology.

    Google Scholar 

  • Garattini, S. and Valzelli, L. (1965). Serotonin. Amsterdam: Elsevier Publishing Company.

    Google Scholar 

  • Giacovazzo, M. (1970). Pathophysiological bases for a new treatment of headache. Proceedings of International Migraine-Headache Symposium, Florence, page 32, World Federation of Neurology.

    Google Scholar 

  • Hanington, E. (1967). Preliminary report on tyramine headache. Brit. med. J. 2, 550–551.

    Article  Google Scholar 

  • Hanington, E. (1970). Dietary factors in migraine. In Kliniske aspekter migrœneforskningen, page 31 (Redigeret af: Axel Klee og Karen Ulrich) Symposium af holdt af Dansk Migrœneselskab og DAK-Laboratoriet, Kobenhavn, Udgivet af Danmarks Apotekerforening.

    Google Scholar 

  • Hanington, E. and Harper, A. Murray (1970). Hypothesis for migraine. In Kliniske aspekter i migraeneforskningen, page 39 (Redigeret af: Axel Klee og Karen Ulrich), Symposium afholdt af Dansk Migrœneselskab og DAK-Laboratoriet, Kobenhavn, Udgivet af Danmarks Apotekerforening.

    Google Scholar 

  • Harper, A. Murray (1970). Experimental studies of tyramine and noradrenaline on the cerebral and extracerebral circulations. In Kliniske aspekter i migrœneforskningen, page 39 (Redigeret af: Axel Klee og Karen Ulrich), Symposium af holdt af Dansk Migrœneselskab og DAK-Laboratoriet, Kobenhavn, Udgivet af Danmarks Apotekerforening.

    Google Scholar 

  • Hilton, Barbara P. and Cumings, J. N. (1971). An assessment of platelet aggregation induced by 5-hydroxytryptamine. J. clin. Path. (In Press.)

    Google Scholar 

  • Holmsen, H. and Day, H. J. (1970). The selectivity of the thrombin-induced platelet release reaction: Subcellular localization of released and retained constituents. J. Lab. clin. Med. 75, 840–855.

    Google Scholar 

  • Kimball, R. W., Friedman, A. P. and Vallejo, E. (1960). Effect of serotonin in migraine patients. Neurology, Minneap. 10, 107–111.

    Article  Google Scholar 

  • Lance, J. W. (1969). The Mechanism and Management of Headache, page 102. London: Butterworths.

    Google Scholar 

  • Murray, K. (1970). Nucleotide “maps” of digests of deoxyribonucleic acid. Biochem. J. 118, 831–841.

    Google Scholar 

  • Owman, C. and Nielsen, K. C. (1970). The role of amine mechanisms in the vaso-motor regulation of cranial arteries. Proceedings of International Migraine-Headache Symposium, Florence, page 31, World Federation of Neurology.

    Google Scholar 

  • Page, Irvine H. (1968). Serotonin. Chicago: Year Book Medical Publishers, Inc.

    Google Scholar 

  • Poller, L. (1970). Relation between oral contraceptive hormones and blood clotting. J. Clin. Path. 23, suppl. (Ass. Clin. Path.), 3, 67–74.

    Google Scholar 

  • Pratt, R. T. C. (1967). The Genetics of Neurological Disorders, page 122. London: Oxford University Press.

    Google Scholar 

  • Salzman, E. W. (1962). Effect of reserpine on hemostasis in the rabbit. Thromb. Diath. Hœmorrh. 7, 507–513.

    Google Scholar 

  • Sandler, M., Youdim, M. B. H., Southgate, J. and Hanington, E. (1970). The role of tyramine in migraine: Some possible biochemical mechanisms. In Background to Migraine, page 103. London: William Heinemann Medical Books.

    Google Scholar 

  • Schumacher, G. A. and Wolff, H. G. (1941). Experimental studies on headache; contrast of histamine headache with headache of migraine and that associated with hypertension; contrast of vascular mechanisms in preheadache and in headache phenomena of migraine. Arch. Neurol. Psychiat., Chicago, 45, 199–214.

    Article  Google Scholar 

  • Sicuteri, F., Buffoni, F., Anselmi, B. and del Bianco, P. L. (1970). Migraine as infradian rhythmical disease: a research on platelets monoamino-oxidase. Proceedings of International Migraine-Headache Symposium, Florence, page 93, World Federation of Neurology.

    Google Scholar 

  • Sicuteri, F., Lombardi, V., Michelacci, S. and Franchi, G. (1961a). Variazioni dinimiche del tromboelastogramma durante le crisi di cefalea. Vascolare ipocoagulabilità come probabile espressione di liberazione di eparina dai mastociti dei tessuti. Settim. med. 49, 835–839.

    Google Scholar 

  • Sicuteri, F., Testi, A. and Anselmi, B. (1961b). Biochemical investigations in headache: increase in the hydroxyindoleacetic acid excretion during migraine attacks. Int. Arch. Allergy, 19, 55–58.

    Article  Google Scholar 

  • Tretyakova, K. A. and Fets, A. N. (1969). Total blood serotonin concentration in patients with migraine during and between attacks. Zh. Nevropat. Psikhiat. Korsakov, 69, 831–835.

    Google Scholar 

  • Zweifler, A. J. (1967). Impairment of platelet function and thrombus growth in reserpine-treated rabbits. J. Lab. clin. Med. 70, 16–22.

    Google Scholar 

  • Zweifler, A. J. and Boddy, J. (1965). Thrombus propagation in the carotid artery of the rabbit. A method of study. Arch. Path., Chicago, 80, 636–640.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer Science+Business Media New York

About this chapter

Cite this chapter

Cumings, J.N. (1971). Sandoz Lecture Migraine—A Biochemical Disorder?. In: Cumings, J.N. (eds) Background to Migraine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4577-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4577-1_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4579-5

  • Online ISBN: 978-1-4757-4577-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics