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Atlas of Osteoporosis pp 27–39Cite as

Genetics of Osteoporosis

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Abstract

Osteoporosis is one of the most common bone and mineral disorders in all aging communities. It is characterized by low bone mass, and thus low bone strength, which results in fractures from relatively minor trauma. Although osteoporotic fractures are most commonly observed among the elderly, the pathogenesis of osteoporosis starts early in life and involves the interaction of multiple factors [1, 2]. Genetic epidemiologic studies provide descriptive data that convincingly demonstrate population and ethnic differences. In addition, studies of familial aggregation and familial transmission patterns and comparisons of twin concordance rates consistently point to susceptibility to developing osteoporosis being inherited in a significant proportion of individuals. The distributions of quantitative skeletal phenotypes in the general population do not conform to a monogenic mode of inheritance. Rather, susceptibility to osteoporosis appears, to involve a complex interplay between both genetic and environmental factors. Initial association studies examined polymorphisms in the vitamin D receptor and the impact of dietary calcium and vitamin D intake.

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Authors
  1. Robert F. Klein
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Editors and Affiliations

  1. Department of Endocrinology, General Clinical Research Center, Oregon Health and Science University, Portland, Oregon, USA

    Eric S. Orwoll MD (Professor of Medicine, Program Director) (Professor of Medicine, Program Director)

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Klein, R.F. (2003). Genetics of Osteoporosis. In: Orwoll, E.S. (eds) Atlas of Osteoporosis. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-4561-0_3

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  • DOI: https://doi.org/10.1007/978-1-4757-4561-0_3

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-4563-4

  • Online ISBN: 978-1-4757-4561-0

  • eBook Packages: Springer Book Archive

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