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Pharmacokinetics and Biopharmaceutical Aspects of Some Anti-Glaucoma Drugs

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Book cover Ophthalmic Drug Delivery

Part of the book series: FIDIA Research Series ((FIDIA,volume 11))

Abstract

The therapy of glaucoma has used several classes of active ingredients which were mostly cholinergic and adrenergic drugs. The carbonic anhydrase inhibitors were essentially systemic drugs but recently new potent compounds have been described to be active after topical administration. Each class of drugs has a different pharmacokinetic behaviour due to the physico-chemical properties of the individual compounds. The dynamics of ocular fluids, especially the turnover of tears, are responsible for a poor availability of drugs administered topically in the conjunctival cul-de-sac. The recent galenic developments in ophthalmic formulations have essentially aimed at achieving better control of the residence of anti-glaucoma drugs close to the anterior segment of the eye and derivatization and prodrug approaches have improved transcorneal penetration.

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Authors and Affiliations

  1. Merck Sharp & Dohme-Chibret, Centre de Recherche, Route de Marsat, 63203, Riom, France

    B. Plazonnet, J. Grove, M. Durr, C. Mazuel, M. Quint & A. Rozier

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  1. B. Plazonnet
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  2. J. Grove
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  3. M. Durr
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  4. C. Mazuel
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  5. M. Quint
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  6. A. Rozier
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Editor information

Editors and Affiliations

  1. Istituto di Chimica Farmaceutica, dell’Università di Pisa, Pisa, Italy

    Marco Fabrizio Saettone

  2. Clinica Oculistica, Università dell’Aquila, Pisa, Italy

    Massimo Bucci

  3. Pharmazeutisches Institut ETHZ, Zurich, Switzerland

    P. Speiser

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Plazonnet, B., Grove, J., Durr, M., Mazuel, C., Quint, M., Rozier, A. (1987). Pharmacokinetics and Biopharmaceutical Aspects of Some Anti-Glaucoma Drugs. In: Saettone, M.F., Bucci, M., Speiser, P. (eds) Ophthalmic Drug Delivery. FIDIA Research Series, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4175-9_13

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  • DOI: https://doi.org/10.1007/978-1-4757-4175-9_13

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