Abstract
The drainage and ocular distribution of nanoparticles and liposomes was investigated ysing the labelling of the nanoparticle polymer with 14C and the binding of a tracer, 111In-oxine, on to the particles and to the liposomes. The longest precorneal half-life was observed with positively charged liposomes yielding an about 3-fold increase in comparison to a simple solution. The half-life in the inner canthus was prolonged from 5 min to about 20 min. In the inner canthus, nanoparticles had the longest half-life. About 1 % of the initial nanoparticle dose adhered to the corneal and conjunctival surfaces for over 6 hours. While a lower ophthalmic absorption of the lipophilic drug progesterone was observed, a 1.4-fold higher efficacy of the more hydrophilic drug pilocarpine was obtained after binding to nanoparticles as determined by miosis measurements.
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References
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© 1987 Springer Science+Business Media New York
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Kreuter, J. (1987). Nanoparticles and Liposomes in Ophthalmic Drug Delivery. In: Saettone, M.F., Bucci, M., Speiser, P. (eds) Ophthalmic Drug Delivery. FIDIA Research Series, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4175-9_11
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DOI: https://doi.org/10.1007/978-1-4757-4175-9_11
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