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Biodegradable Drug Delivery Systems Based on Polypeptides

  • Chapter
Bioactive Polymeric Systems

Abstract

A new dimension to the use of polymeric materials as drug delivery devices is the incorporation of biodegrability into the system. A number of degradable polymers are potentially useful for this purpose, including synthetic and natural substances. A number of such substances are described in this chapter. However, major emphasis is placed on synthetic poly(α-amino acids). These polymers are useful for matrix and reservoir-type delivery systems and, in addition, when difunctional amino acids, such as glutamic acid, are utilized, polymer/drug conjugates represent another new dimension. In polymer/drug conjugates, the drug is covalently bonded directly to the polymeric “backbone” or to a spacer group between the drug and polymer. The bond must be of a type which hydrolyzes more rapidly than the amide bonds in the polymeric backbone. A number of such conjugates have been synthesized and evaluated for in vitro and in vivo hydrolysis and for potential toxicity. It appears that this concept can be utilized to advantage in the development of delivery systems for a wide variety of bioactive substances.

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA

    Robert V. Petersen

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  1. Robert V. Petersen
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Editor information

Editors and Affiliations

  1. Youngstown State University, Youngstown, Ohio, USA

    Charles G. Gebelein

  2. Wright State University, Dayton, Ohio, USA

    Charles E. Carraher Jr.

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© 1985 Plenum Press, New York

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Petersen, R.V. (1985). Biodegradable Drug Delivery Systems Based on Polypeptides. In: Gebelein, C.G., Carraher, C.E. (eds) Bioactive Polymeric Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0405-1_7

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  • DOI: https://doi.org/10.1007/978-1-4757-0405-1_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0407-5

  • Online ISBN: 978-1-4757-0405-1

  • eBook Packages: Springer Book Archive

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