Abstract
The β-adrenergic agonist, isoproterenol, is well known to increase water intake within 1 hr of its administration to rats (1,2), One of the major contributory mechanisms to this drink is via isoproterenol-induced release of renin from the kidneys (3,4) and the subsequent elevation of circulating angiotensin II (AII) levels. (See also references 5–7 for other mechanisms). AII, administered either peripherally or into circumventricular brain regions such as subfornical organ or anteroventral third ventricle, is itself a potent dipsogen (8–11). However, the evidence that normal levels of AII in blood gain access to these regions of the brain is not compelling, and the inference that peripheral AII exerts its dipsogenic action by a direct effect on the brain is thus based on indirect evidence. For example, peripheral administration of the competitive AII inhibitor, saralasin (sar1, ala8-AII) inhibits the drinking response to centrally-administered AII (12), and lesions of the circumventricular organs inhibit the drink to peripherally-administered AII (11). Further, the brain has its own intrinsic renin-angiotensin system (13) including high affinity receptors for AII in the circumventricular organs (14), yet the ways, if any, in which the central and peripheral renin-angiotensin systems interact have not yet been elucidated.
Supported by contract NCA2-OR204-101 from NASA, Moffett Field, CA.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fitzsimons, J.T., The Physiology Of Thirst And Salt Appetite, Cambridge Univ. Press, Cambridge (1979).
Lehr, D., J. Mallow and K. Krukowski, Copious drinking and simultaneous inhibition of urine flow elicited by beta-adrenergic stimulation and contrary effect of alpha-stimulation, J. Pharm. Exp. Therap. 1, 58:150 (1967).
Peskar, B., D.K. Meyer, U. Tauschman and G. Herting, Influence of isoproterenol, hydralazine, and phentolamine on the renin activity of plasma and renal cortex of rats, Europ. J. Pharmacol. 9: 394 (1970).
Weinberger, M.H., W. Aoi and D.P. Henry, Direct effect of beta-adrenergic stimulation on renin release by the rat kidney slice in vitro, Circ. Res. 37: 318 (1975).
Abraham, S.F., R.N. Baker, E.H. Blaine, D.A. Denton and M.J. McKinley, Water drinking induced in sheep by angiotensina physiological or pharmacological effect? J. Comp. Physiol. Psychol. 88:503 (1975).
Stricker, E.M. and W.G. Bradshaw, The renin-angiotensin system in thirst: a reevaluation, Science 194:1169 (1976).
Tang, M. and J.L. Falk, Sar1-ala8-angiotensin II blocks renin angiotensin but not beta adrenergic thirst, Pharmac. Biochem. Behav. 2:401 (1974).
Buggy, J. and A.K. Johnson, Angiotensin-induced thirst: effects of third ventricle obstruction and periventricular ablation, Brain Res. 149:117 (1978).
Epstein, A.N., J.T. Fitzsimons and B. Rolls, Drinking induced by angiotensin in the brain of the rat, J. Physiol. (London) 210: 457 (3).
Mogenson, G.J. and J. Kucharcyk, Evidence that the lateral hypothalamus and mid-brain participate in drinking elicited by intracranial angiotensin, in Control Mechanisms of Drinking, eds. G. Peters, J.T. Fitzsimons and L. Peters-Haefeli, Springer-Verlag, New York, pp. 127 (1975).
Simpson, J.B. and A. Routtenberg, Subfornical organ: site of drinking elicitation by angiotensin II, Science 181:1172 (1973).
Hoffman, W.E. and M.I. Phillips, Evidence for sar1-ala8-angio-tensin crossing the blood cerebrospinal fluid barrier to antgonize central effects of angiotensin II, Brain Res. 109:541 (1976).
Hirose, S., H. Yokosawa and T. Inagami, Immunochemical identification of the renin in rat brain and distinction from acid proteases, Nature 274:392 (1978).
Sirett, N.E., A.S. McLean, J.J. Bray and J.I. Hubbard, Distribution of angiotensin II receptors in rat brain, Brain Res. 122: 299 (1977).
Laubie, M. and M. Schmitt, Sites of action of clonidine: Centrally mediated increase in vagal tone, centrally mediated hypoten-sive and sympatho-inhibitory effects, Prog. Brain Res. 47:337 (1977).
Pettinger, W.A., T.K. Keeton, W.B. Campbell and D.C. Harper, Evidence for a renal α-adrenergic receptor inhibiting renin release, Circ. Res. 38:338 (1976).
Fregly, M.J. and D.L. Kelleher, Antidipsogenic effect of clonidine on isoproterenol-induced water intake, Appetite 1:279 (1980).
Goldstein, A., Biostatistics, An Introductory Text, MacMillan, New York (1964).
Fregly, M.J., D.L. Kelleher and J.E. Greenleaf, Antidipsogenic effect of clonidine on angiotensin II-, hypertonic saline-, pilocarpine-, and dehydration-induced water intakes, Brain Res. Bull. 7: 661 (1981).
Kikta, D.C, C.C. Barney, R.M. Threatte, M.J. Fregly, N.E. Rowland and J.E. Greenleaf, On the mechanism of serotonin-induced dipso-genesis in the rat, Pharmac. Biochem. Behav. 19:519 (1983).
Threatte, R.M., M.J. Fregly, T.M. Connor and D.C. Kikta, L-5-Hydroxytryptophan-induced drinking in rats: Possible mechanisms for induction, Pharmac. Biochem. Behav. 14:385 (1981).
Rowland, N., Comparison of the suppression by naloxone of water intake induced in rats by hyperosmolality, hypovolemia and angiotensin, Pharmac. Biochem. Behav. 16:87 (1982).
Fregly, M.J., N.E. Rowland and J.E. Greenleaf, Clonidine antagonism of angiotensin-related drinking: a central site of action, Brain Res. 298:321 (1984).
Fregly, M.J., N.E. Rowland and J.E. Greenleaf, Effects of yohim-bine and tolazoline on isoproterenol-and angiotensin II-induced water intake in rats, Brain Res. Bull. 10:121 (1983).
Fregly, M.J., N.E. Rowland and J.E. Greenleaf, A role for pre-synaptic α2-adrenoceptors in angiotensin II-induced drinking in rats, Brain Res. Bull, (in press).
LeDouarec, J.C., H. Schmitt and B. Lucet, Influence de la clonidine et des substances α-sympathomimetique sur la prise d’eau chez le rat assoiffé, J. Pharmac. (Paris) 2:435 (1971).
Greenleaf, J.E. and M.J. Fregly, Dehydration-induced drinking: peripheral and central aspects, Fed. Proc. 41:2507 (1982).
Toates, F.M., Homeostasis and drinking, Behav. Brain Sci. 2: 95 (1979).
Wilson, K.M., N. Rowland and M.J. Fregly, Drinking: A final common pathway? Appetite (in press).
Rockhold, R.W. and R.W. Caldwell, Effect of lesions of the nucleus tractus solitarii on the cardiovascular actions of clonidine in conscious rats, Neuropharmacology 18:347 (1979).
Rockhold, R.W. and R.W. Caldwell, Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat, Neuropharmacology 19:919 (1980).
Summy-Long, J.Y., L.C. Keil, K. Deen, L. Rosella and W.B. Severs, Endogenous opioid peptide inhibition of the central actions of angiotensin, J. Pharm. Exp. Therap. 211:619 (1981).
Summy-Long, J.Y., L.M. Rosella and L.C. Keil, Effects of centrally administered endogenous opioid peptides on drinking behavior, increased plasma vasopressin concentration and pressor response to hypertonic sodium chloride, Brain Res. 221:343 (1981).
Oatley, K., Stimulation and theory of thirst, in The Neuropsychology Of Thirst: New Findings And Advances In Concepts, eds. A.N. Epstein, H.R. Kissileff and E, Stellar, Winston, Washington, D.C., p. 199 (1973).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fregly, M.J., Rowland, N.E. (1986). Role for α2-Adrenoceptors in Experimentally-Induced Drinking in Rats. In: de Caro, G., Epstein, A.N., Massi, M. (eds) The Physiology of Thirst and Sodium Appetite. NATO ASI Series, vol 105. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0366-5_68
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0366-5_68
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0368-9
Online ISBN: 978-1-4757-0366-5
eBook Packages: Springer Book Archive