Abstract
For well over a decade there has been strong evidence indicating that Epstein-Barr (EB) virus, one of the six human herpesviruses, forms an essential link in the complicated chain of events leading to the development of two human cancers (reviewed in Epstein and Achong, 1979), endemic Burkitt’s lymphoma (BL) (Burkitt, 1963) and undifferentiated nasopharyngeal carcinoma (NPC) (Shanmugaratnam, 1971). More recently, it has emerged that the virus also seems to be causally linked to the malignant lymphomas which arise with undue frequency in immunodepressed individuals (Purtillo, 1984).
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References
Allison, A.C. and Byars, N.E., 1986, An adjuvant formulation that selectively elicits the formation of antibodies of protective isotype and cell mediated immunity, J. Immunol.Methods, 95: 157.
Beisel, C., Tanner, J., Matsuo, T., Thorley-Lawson, D., Kezdy, F. and Kieff, E., 1985, Two major outer envelope glycoproteins of Epstein-Barr virus encoded by the same gene, J.Virol., 54: 665.
Biggin, M., Farrell, P.J. and Barrell, B.G., 1984, Transcription and DNA sequence of the Bam HIL fragment of B95-8 Epstein-Barr Virus, EMBO.J., 3: 1083.
Burkitt, D., 1963, A lymphoma syndrome in tropical Africa, in: “International Review of Experimental Pathology”, G.W. Richter and M.A. Epstein, eds., Academic Press, New York.
Cammoun, M., Hoerner, G.V. and Mourali, N., 1974, Tumors of the nasopharynx in Tunisia: an anatomic and clinical study based on 143 cases, Cancer, 3: 184.
Churchill, A.E., Payne, L.N. and Chubb, R.C., 1969, Immunization against Marek’s disease using a live attenuated virus, Nature, 221: 744.
Cleary, M.L., Epstein, M.A., Finerty, S., Dorfman, R.F., Bornkamm, G.W., Kirkwood, J.K., Morgan, A.J. and Sklar, J., 1985, Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B cell clones, Science, 228: 722.
Clifford, P., 1970, A review: On the epidemiology of nasopharyngeal carcinoma, Int.J.Cancer, 5: 287.
Conway, M., Morgan, A. and Mackett, M., 1988, Expression of Epstein-Barrvirus antigen gp340/220 in mouse fibroblasts using a bovine papilloma virus vector, submitted to press
David, E.M. and Morgan, A.J., 1988, Efficient purification of Epstein-Barr virus membrane antigen gp340 by fast protein liquid chromatography, J. Immunol. Methods, 108: 231.
Deinhardt, F. and Jilg, W., 1986, Vaccines against hepatitis, Ann. Inst. Pasteur, Virol., 137E:79.
Doll, R. and Peto, R., 1976, Mortality in relation to smoking: 20 years’ observation on male British doctors, Brit. Med. J., 2: 1525.
Epstein, M.A., 1976, Epstein-Barr virus — is it time to develop a vaccine program? J. Nat. Cancer Inst., 56: 697.
Epstein, M.A., 1984, A prototype vaccine to prevent Epstein-Barr (EB) virus-associated tumours, Proc.Roy.Soc.B.Lond., 221: 1.
Epstein, M.A. and Achong, B.G., 1979, “The Epstein-Barr Virus”, M.A. Epstein and B.G. Achong, eds., Springer, Berlin.
Epstein, M.A., Morgan, A.J., Finerty, S., Rändle, B.J. and Kirkwood, J.K., 1985, Protection of cotton-top tamarins against Epstein-Barr virus-induced malignant lymphoma by a prototype subunit vaccine, Nature, 318: 287.
Henle, W. and Henle, G., 1969, The relation between the Epstein-Barr virus and infectious mononucleosis, Burkitt’s lymphoma and cancer of the postnasal space, E.African Med.J., 46: 402.
Hummel, M., Thorley-Lawson, D.A. and Kieff, E., 1984, An Epstein-Barr virus DNA fragment encodes messages for the two major envelope glycoproteins (gp350/300 and gp220/200), J.Virol., 49: 413.
International Agency for Research on Cancer, 1985, An intervention study to evaluate the effectiveness of Hepatitis B vaccine for the prevention of hepatocellular carcinoma in a high risk population, IARC Working Paper 3/6:1.
Kaaden, O.R. and Dietzschold, B., 1974, Alterations of the immunological specificity of plasma membranes of cells infected with Marek’s disease and turkey herpes viruses, J.Gen.Virol., 25: 1.
Kirkwood, J.K., Epstein, M.A. and Terlecki, A.J., 1983, Factors influencing population growth of a colony of cotton-top tamarins, Lab.Animals, 17: 35.
Kirkwood, J.K., Epstein, M.A, Terlecki, A.J. and Underwood, S.J., 1985, Rearing a second generation of cotton-top tamarins (Saguinus oedipus oedipus) in captivity, Lab.Animals, 19: 269.
Lowe, R.S., Keller, P.M., Keech, B.J., Davison, A.J., Whang, Y., Morgan, A.J., Kieff, E. and Ellis, R.W., 1987, Varicella-zoster virus as a live vector for the expression of foreign genes, Proc. Nat. Acad. Sci. USA, 84: 3896.
Mackett, M. and Arrand, J.R., 1985, Recombinant vaccinia virus induces neutralising antibodies in rabbits against Epstein-Barr virus membrane antigen gp340, EMBO, J., 4: 3229.
Marek, J., 1907, Multiple Nervenentzündung (polyneuritis) bei Hühnern, Deutsch.Tierärztl Wschr., 15: 417.
Miller, G., Shope, T., Coope, D., Waters, C., Pagano, J., Bornkamm, G.W. and Henle, W., 1977, Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum, antibody responses, demonstration of viral DNA, and characterization of viruses, J.Exp.Med., 145: 948.
Morein, B., Lovgren, K., Hogland, S. and Sundquist, B., 1987, The iscom: an immunostimulating complex, Immunol. Today, 8: 333.
Morgan, A.J., Finerty, S., Lovgren, K., Scullion, F.T. and Morein, B., 1988, Prevention of Epstein-Barr (EB) virus-induced lyhmphoma in cottontop tamarins by vaccination with the EB virus envelope glycoprotein gp340 incorporated into Iscoms, J.Gen.Virol., in press.
Morgan, A.J., Mackett, M., Finerty, S., Arrand, J., Scullion, F. and Epstein, M.A., 1988, Recombinant vaccinia viruses expressing Epstein-Barr virus glycoprotein gp340 protect cottontop tamarins against EB virus-induced malignant lymphomas, J. Med. Virol., in press.
Morgan, A.J., North, J.R. and Epstein, M.A., 1983, Purification and properties of the gp340 component of Epstein-Barr (EB) virus membrane antigen (MA) in an immunogenic form, J.Gen.Virol., 64: 455.
Moss, D.J. and Pope, J.H., 1972, Assay of the infectivity of the Epstein-Barr virus by transformation of human leucocytes in vitro, J. Gen. Virol., 17: 233.
Niederman, J.C., Evans, A.S., Subrahmanyan, L. and McCollum, R.W., 1970, Prevalence, incidence and persistence of EB virus antibody in young adults, New Eng.J.Med., 282: 361.
North, J.R., Morgan, A.J., Thompson, J.L. and Epstein, M.A., 1982, Quantification of an EB virus-associated membrane antigen (MA) component, J.Virol. Methods, 5: 55.
Okazaki, W., Purchase, H.G. and Burmester, B.R., 1970, Protection against Marek’s disease by vaccination with a herpesvirus of turkeys, Avian Dis., 14: 413.
Payne, L.N., Fraxier, J.A. and Powell, P.C., 1976, Pathogenesis of Marek’s disease, in: “International Review of Experimental Pathology”, G.W. Richter and M.A. Epstein, eds., Academic Press, New York.
Pereira, M.A., Blake, J.M. and Macrae, A.D., 1969, EB virus antibody at different ages, Brit.Med. J., 4: 526.
Purtilo, D.T., 1984, Immune deficiency and cancer. Epstein-Barr virus and lymphoproliferative malignancies, Plenum Medical Book Co., New York.
Randle, B.J. and Epstein, M.A., 1984, A highly sensitive enzyme-linked immunosorbent assay to quantitate antibodies to Epstein-Barr virus membrane antigen gp340, J.Virol. Methods, 9: 201.
Rickinson, A.B., 1986, Cellular immunological responses to the virus infection in: “The Epstein-Barr virus: Recent Advances”, M.A. Epstein and B.G. Achong, eds., William Heinemann Medical Books, London.
de Schryver, A., Klein, G., Hewetson, J., Rocchi, G., Henle, W., Henle, G., Moss, D.J. and Pope, J.H., 1974, Comparison of EBV neutralization tests based on abortive infection or transformation of lymphoid cells and their relation to membrane reactive antibodies (anti MA), Int. J. Cancer, 13: 353.
Schultz, L.D., Tanner, J., Hofmann, K., Emini, E., Kieff, E. and Ellis, R.W., 1987, Expression and analysis of EBV gp350 in yeast Saccharomyces cerevisiae, in: “Epstein-Barr Virus and Human Disease”, P.H. Levine, D.V. Ablashi, M. Nonoyama, G.R. Pearson and R. Glaser, eds., Humana Press, Clifton.
Shanmugaratnam, K., 1971, Studies on the etiology of nasopharyngeal carcinoma, in: “International Review of Experimental Pathology”, G.W. Richter and M.A. Epstein, eds., Academic Press, New York.
Takahashi, M., Otsuka, T., Okuno, Y., Asano, Y., Yazaki, T. and Isomura, S., 1974, Live varicella vaccine used to prevent the spread of varicella in children in hospital, Lancet ii: 1288.
de Thé, G., 1979, Demographic studies implicating the virus in the causation of Burkitt’s lymphoma; prospects for nasopharyngeal carcinoma, in: “The Epstein-Barr Virus”, M.A. Epstein and B.G. Achong, eds., Springer, Berlin.
University Health Physicians and PHLS Laboratories, 1971, Infectious mononucleosis and its relationship to EB virus antibody, Brit. Med. J., iv: 643.
Weibel, R.E., Neff, B.J., Kuter, B.J., Guess, H.A., Rothenburger, C.A. Fitzgerald, A.J., Connor, K.A., McLean, A.A., Hilleman, M.R. and Buynak, E.B., 1984, Live attenuated varicella virus vaccine: efficiency trial in healthy children, New Eng.J.Med., 310: 1409.
Whang, Y., Silberklang, M., Morgan, A., Munshi, S., Lenny, A.B., Ellis, R.W. and Kieff, E., 1987, Expression of Epstein-Barr virus gp350/220 gene in rodent and primate cells, J.Virol., 61: 1796.
Zuckerman, A.J., 1985, Prevention of hepatocellular carcinoma by immunization against hepatitis B, in: “International Review of Experimental Pathology”, G.W. Richter and M.A. Epstein, eds., Academic Press, Orlando.
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Epstein, M.A. (1989). Recent Progress with Vaccines Against Epstein-Barr Virus Infection. In: Gregoriadis, G., Allison, A.C., Poste, G. (eds) Immunological Adjuvants and Vaccines. NATO ASI Series, vol 179. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0283-5_20
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