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The Role of Carbohydrate as a Post-Translational Modification of the Receptor for Epidermal Growth Factor

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Advances in Post-Translational Modifications of Proteins and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((NATO ASI F,volume 231))

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Abstract

The receptor for EGF is an integral membrane protein that mediates the mitogenic response of target cells to EGF and EGF-like polypeptides (1). The EGF receptor has been purified from cultured human tumor cells (2,3) and mouse liver (4). The receptor is a glycoprotein having an estimated molecular mass of approximately 170,000 daltons and no subunit structure. In addition to the N-linked oligosaccharide chains, the EGF receptor is also modified post-translationally by phosphate on serine, threonine, and tyrosine residues and extensive disulfide bond arrangement is predicted. In addition to the molecule’s ligand binding capacity, the receptor acts as an allosteric enzyme; it contains a tyrosine-specific protein kinase activity that is activated by the binding of EGF (5,6). However, substrates of this receptor-kinase that are physiologically relevant to mito-genesis have not yet been identified. The focus of this article will be on the glycosylation of the EGF receptor during the biosynthesis of this molecule.

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Authors and Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Ann M. Soderquist, Gordon Todderud & Graham Carpenter

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  1. Ann M. Soderquist
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  2. Gordon Todderud
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  3. Graham Carpenter
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  1. University of Naples, Naples, Italy

    Vincenzo Zappia , Patrizia Galletti  & Raffaele Porta ,  & 

  2. University of Texas Health Science Center, Houston, Texas, USA

    Finn Wold

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Soderquist, A.M., Todderud, G., Carpenter, G. (1988). The Role of Carbohydrate as a Post-Translational Modification of the Receptor for Epidermal Growth Factor. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_48

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  • DOI: https://doi.org/10.1007/978-1-4684-9042-8_48

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