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Morphological Aspects of Lymphocyte Mediated Cytotoxicity

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Mechanisms of Cell-Mediated Cytotoxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 146))

Abstract

In this review I am going to discuss the contact-mediated killing of nucleated mammalian cells by cytotoxic T cells (Tc cells) and antibody-dependent K cells. I wish to suggest that the mechanism of killing by Tc cells and K cells is similar, although a different receptor-ligand interaction is involved in the two types of killing. Tc cells have a specific receptor which reacts with antigen on the target cell while K cells have an Fc receptor reacting with antibody on the surface of the target cell. Because of apparent similarities between NK cells and K cells it is possible that all three classes of lymphoid cell share the same mechanism of killing.

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Authors and Affiliations

  1. National Institute for Medical Research, The Ridgeway, NW7 1AA, Mill Hill, London, UK

    Colin J. Sanderson

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  1. Colin J. Sanderson
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Editors and Affiliations

  1. University of California, Los Angeles, California, USA

    William R. Clark

  2. Centre d’lmmunologie, INSERM-CNRS de Marseille-Luminy, Marseille, France

    Pierre Golstein

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© 1982 Plenum Press, New York

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Sanderson, C.J. (1982). Morphological Aspects of Lymphocyte Mediated Cytotoxicity. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_1

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  • DOI: https://doi.org/10.1007/978-1-4684-8959-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8961-3

  • Online ISBN: 978-1-4684-8959-0

  • eBook Packages: Springer Book Archive

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