Abstract
The DNA in the eukaryotic nucleus has been found to be arranged in a series of supercoiled loops. This supercoiled loop-organization results from DNA attachment to a structure which is mainly proteic, the so-called nuclear matrix (1–9). This DNA organization remains stable throughout the cellular cycle as far as the size of DNA loops and the anchorage sites are concerned (5, 10, 11). It is worthwhile noting that this type of organization has been found in all cells whatever their state of differentiation (early embryonic stage up to fully differentiated cells (21)).
This work is dedicated to the memory of Professor Mario Buongiorno-Nardelli.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Laemmli, U.K., Cheng, S.M., Adolph, K.W., Paulson, J.R., Brown, J.A. and Baumbach, W.R. (1977) Cold Spring Harbor Symp. Quant. Biol. 42, 351.
Comings, D.E. (1978) in: the Cell Nucleus (H. Bush ed.) Acad. Press, New York, 4, 345.
Georgiev, G.P., Nedospasov, S.A. and Bakayev, V.U. (1978) in: the Cell Nucleus (H. Bush ed.) Acad. Press, New York, 6, 3.
Shaper, J.H., Pardoll, D.M., Kaufmann, S.H., Barrack, E.R., Vogelstein, B. and Coffey, D.S. (1979) in: Advances in Enzyme Regulation (G. Weber ed.), Pergamon Press, Oxford, 17, 213.
Cook, P.R. and Brazell, I.A. (1980) Nucl. Acids Res. 8, 2895.
Pardoll, D.M., Vogelstein, B. and Coffey, D.S. (1980) Cell, 19, 527.
Berezney, R. and Buchholtz, L.A. (1981) Exp. Cell Res. 132, 1.
McCready, S.J., Godwin, J., Mason, D.W., Brazell, I.A. and Cook, P.R. (1980) J. Cell Sci. 46, 365.
Vogelstein, B., Pardoll, D.M. and Coffey, D.S. (1980) Cell, 22, 79.
Razin, S.V., Mantieva, V.L. and Georgiev, G.P. (1979) Nucl. Acids Res. 7, 1713.
Wray, V.P., Elgin, S.C.R. and Wray, W. (1980) Nucl. Acids Res. 8, 4155.
Buongiorno-Nardelli, M., Micheli, G., Carri, M.T. and Marilley, M. (1982) Nature, 298, 100.
Dijkwel, P.A., Mullenders, L.H.F. and Wanka, F. (1979) Nucl. Acids Res. 6, 219.
Nelkin, B.D., Pardoll, D.M. and Vogelstein, B. (1980) Nucl. Acids Res. 8, 5623.
Buckler-White, A.J., Humphrey, G.W. and Pigiet, V. (1980) Cell, 22, 37.
Robinson, S.I., Nelkin, B.D. and Vogelstein, B. (1982) Cell, 28, 99.
Cook, P.R., Lang, J., Hayday, A., Lania, L., Fried, M., Chiswell, D.J. and Wyke, J.A. (1982) EMBO J. I, 447.
Jackson, D.A., McCready, S.J. and Cook, P.R. (1981) Nature, 292, 552.
Smith, G.R. (1981) Cell, 24, 599.
Carnevali, F., Caserta, M. and Di Mauro, E. (1983) J. Mol. Biol. 165, 59.
Pedone, F., Felicetti, P. and Ballario, P. (1982) Nucl. Acids Res. 10, 5197.
Laskey, R.A. and Harland, R.M. (1981) Cell, 24, 283.
Carri, M.T. and Buongiorno-Nardelli, M. Exp. Cell. Res., in press.
Bozzoni, I., Baldari, C.T., Amaldi, F. and Buongiorno-Nardelli, M. (1981) Eur. J. Biochem. 118, 585.
Lilley, D.M.J. (1980) Proc. Nat. Acad. Sci. USA, 77, 6468.
Southern, E.M. (1975) J. Mol. Biol. 98, 503.
Pardoll, D.M. and Vogelstein, B. (1980) Exp. Cell Res. 128, 466.
Hunt, B.F. and Vogelstein, B. (1981) Nucl. Acids Res. 9, 349.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Marilley, M., Buongiorno-Nardelli, M. (1984). Relationship between the Organization of DNA Loop Domains and of Replicons in the Eukaryotic Genome. In: Proteins Involved in DNA Replication. Advances in Experimental Medicine and Biology, vol 179. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8730-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8730-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8732-9
Online ISBN: 978-1-4684-8730-5
eBook Packages: Springer Book Archive