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Atherosclerosis and Inflammation

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The Thrombotic Process in Atherogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 104))

Abstract

It is probably safe to state that atherosclerosis is the sum of several different processes. Each one of the past and current theories of atherosclerosis emphasizes one of these processes. Thus, if we open a contemporary textbook of pathology (1), we find at least four theories: (1) lipid insudation, (b) structural or metabolic alteration of the arterial wall, (c) intimal stress or injury, (d) thrombogenesis or encrustation. To these we should add the two newer theories that emphasize a further aspect of the process, cell proliferation: the theory of Ross et al. (2, 3) which gives platelets the stimulating role, and the theory of Benditt (4, 5) in which the proliferation is considered akin to neoplasia.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Isabelle Joris & Guido Majno

Authors
  1. Isabelle Joris
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  2. Guido Majno
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Editor information

Editors and Affiliations

  1. Department of Pathology, Medical College of Georgia, USA

    A. Bleakley Chandler

  2. National Heart, Lung, and Blood Institute, National Institutes of Health, USA

    Karl Eurenius  & Gardner C. McMillan  & 

  3. Division of Scientific Affairs, American Heart Association, USA

    Curtis B. Nelson

  4. Department of Pathology, University of Texas, San Antonio, USA

    Colin J. Schwartz

  5. Department of Medicine, New York University School of Medicine, USA

    Stanford Wessler

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© 1978 Plenum Press, New York

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Joris, I., Majno, G. (1978). Atherosclerosis and Inflammation. In: Chandler, A.B., Eurenius, K., McMillan, G.C., Nelson, C.B., Schwartz, C.J., Wessler, S. (eds) The Thrombotic Process in Atherogenesis. Advances in Experimental Medicine and Biology, vol 104. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7787-0_10

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  • DOI: https://doi.org/10.1007/978-1-4684-7787-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7789-4

  • Online ISBN: 978-1-4684-7787-0

  • eBook Packages: Springer Book Archive

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