Abstract
The focus of this chapter is on the integral membrane glycoproteins of the animal cell involved in cell-cell and cell-substratum adhesion. The approach to the subject, both intellectually and experimentally, reflects not only the prejudices of the authors but also the ideas and concepts gleaned from the literature and from conversations with colleagues. For the free interchange of ideas, we are grateful; for misinterpretations or oversights, we apologize. We have focused attention on that body of experimental data that has used both biochemical and biological approaches in an attempt to understand the adhesion process. Immunology, with its potential for specificity, has played a particularly crucial role in the discovery of adhesion-related glycoproteins and, with the increased use of monoclonal antibody technology, will play an increasingly important role in exploring this area. It is a tool that must be used with caution, however, as will be noted throughout the chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abercrombie, M. J., Heaysman, J. E. M., and Pegrum, S. M., 1971, Locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella, Exp. Cell Res 67: 359–367.
Aplin, J. D., and Hughes, R. C., 1982, Complex carbohydrates of the extracellular matrix: Structures, interactions and biological roles, Biochim. Biophys. Acta 694: 375–418.
Aplin, J. D., Hughes, R. C., Jaffe, C. L., and Sharon, N., 1981, Reversible crosslinking of cellular components of adherent fibroblasts to fibronectin and lectin coated substrata, Exp. Cell Res 134: 488–494.
Avnur, Z., and Geiger, B., 1981, Substrate-attached membranes of cultured cells: Isolation and characterization of ventral cell membranes and the associated cytoskeleton, J. Mol. Biol 53: 361–379.
Badley, R. A., Lloyd, C. W., Woods, A., Carruthers, L., Allcock, C., and Rees, D. A., 1978, Mechanisms of cellular adhesion. III. Preparation and preliminary characterization of adhesions, Exp. Cell Res 117: 231–244.
Badley, R. A., Woods, A., Smith, C. G., and Rees, D. A., 1980, Actomyosin relationships with surface features in fibroblast adhesion, Exp. Cell Res 126: 263–272.
Bayley, S., and Rees, D., 1982, Analysis of proteins, glycoprotein and glycosaminoglycans of fibroblast adhesions to substratum, Biochim. Biophys. Acta 689: 351–362.
Bennett, V., Davis, J., and Fowler, W. E., 1982, Brain spectrin: A membrane-associated protein related in structure and function to erythrocyte spectrin, Nature (London) 299: 126–128.
Bertolotti, R., Rutishauser, U., and Edelman, G. M., 1980, A cell surface molecule involved in aggregation of embryonic liver cells, Proc. Natl. Acad. Sci. USA 77: 4831–4835.
Birchmeier, C., Kreis, T. E., Eppenberger, H. M., Winterhalter, K. H., and Birchmeier, W., 1980, Corrugated attachment membrane on WI-38 fibroblasts: Alternating fibronectin fibers and actin-containing focal contacts, Proc. Natl. Acad. Sci. USA 77: 4108–4112.
Birchmeier, W., Liebermann, T. A., Imhof, B. A., and Kreis, T. E., 1981, Intracellular and extracellular components involved in the formation of ventral surfaces of fibroblasts, Cold Spring Harbor Symp. Quant. Biol 46: 755–767.
Birdwell, C. R., Gospodarowicz, D., and Nicolson, G. L., 1978, Identification, localization and role of fibronectin in cultured bovine endothelial cells, Proc. Natl. Acad. Sci. USA 75: 3273–3277.
Brackenbury, R., Thiery, J.-P., Rutishauser, U., and Edelman, G. M., 1977, Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell—cell binding, J. Biol. Chem 252: 6835–6840.
Brackenbury, R., Rutishauser, U., and Edelman, G., 1981, Distinct calcium-independent and calcium-dependent adhesion systems of chicken embryo cells, Proc. Natl. Acad. Sci. USA 78: 387–391.
Branton, D., Cohen, C. M., and Tyler, J., 1981, Interaction of cytoskeletal proteins on the human erythrocyte membrane, Cell 24: 24–33.
Briles, E. B., 1982, Lectin-resistant cell surface variants of eukaryotic cells, Int. Rev. Cytol 75: 101–166.
Burridge, K., and Feramisco, J., 1980, Microinjection and localization of a 130K protein in living fibroblasts: A relationship to actin and fibronectin, Cell 19: 587–595.
Burridge, K., Kelly, T., and Mangeat, P., 1982, Nonerythrocyte spectrins: Actin—membrane attachment problems occurring in many cell types, J. Cell Biol 95: 478–487.
Buskirk, D. R., Thiery, J.-P., Rutishauser, U., and Edelman, G. M., 1980, Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retina, Nature (London) 285: 488–489.
Carter, W. G., 1982, The cooperative role of the transformation-sensitive glycoproteins gp140 and fibronectin in cell attachment and spreading, J. Biol. Chem 257: 3249–3257.
Carter, W. G., and Hakomori, S.-I., 1981, A new cell surface detergent-insoluble glycoprotein matrix of human and hamster fibroblasts, J. Biol. Chem 256: 6953–6960.
Chen, W.-T., 1982, Development of the attachment sites between the cell surface and the extracellular matrix in cultured fibroblasts, J. Cell Biol. 95: 100a.
Chen, W.-T., and Singer, J., 1980, Fibronectin is not present in the focal adhesions formed between normal cultured fibroblasts and their substrate, Proc. Natl. Acad. Sci. USA 77: 7318–7322.
Chen, W.-T., and Singer, J., 1982, Immunoelectron microscopic studies of the sites of cell— substratum and cell—cell contact in cultured fibroblasts, J. Cell Biol 95: 205–223.
Cohen, S. M., Gorbsky, G., and Steinberg, M., 1983, Immunochemical characterization of related families of glycoproteins in desmosomes, J. Biol. Chem 258: 2621–2627.
Cook, J. H., and Lilien, J., 1982, The accessibility of certain proteins on embryonic chick neural retina cells in iodination and tryptic removal is altered by calcium, J. Cell Sci. Cell Sci. 55: 85–103.
Couchman, J. R., Rees, D. A., Green, M. R., and Smith, C. G., 1982, Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts, J. Cell Biol 93: 402–410.
Couchman, J. R., Höök, M., Rees, D. A., and Timpl, R., 1983, Adhesion, growth and matrix production of fibroblasts on laminin substrates, J. Cell Biol 96: 177–183.
Coudrier, E., Reggio, H., and Louvard, D., 1981, The cytoskeleton of intestinal microvilli contains two polypeptides immunologically related to proteins of skeletal muscle, Cold Spring Harbor Symp. Quant. Biol 46: 881–892.
Courtoy, P. J., Kanwar, Y. S., Hynes, R. O., and Farquhar, M. G., 1980, Fibronectin localization in the rat glomerulus, J. Cell Biol 87: 691–698.
Culp, L., 1978, Biochemical determination of cell adhesion, Curr. Top. Membr. Transp 11: 327–395.
Curtis, A. S. G., 1964, The mechanism of adhesion of cells to glass, J. Cell Biol 20: 199–215.
Damsky, C. H., Wylie, D., and Buck, C. A., 1979, Studies on the function of cell surface glycoproteins. II. Possible role of surface glycoproteins in the control of cytoskeletal organization and surface morphology, J. Cell Biol 80: 403–415.
Damsky, C. H., Knudsen, K. A., Dorio, R. J., and Buck, C. A., 1981, Manipulation of cell—cell and cell—substratum interactions in mouse mammary tumor epithelial cells using broad spectrum antisera, J. Cell Biol 89: 173–184.
Damsky, C. H., Knudsen, K. A., and Buck, C. A., 1982, Integral membrane glycoproteins related to cell—substratum adhesion in mammalian cells, J. Cell. Biochem 18: 1–13.
Damsky, C. H., Richa, J., Solter, D., Knudsen, K. A., and Buck, C. A., 1983a, Identification and purification of a cell-surface glycoprotein-mediated intercellular adhesion in embryonic and adult tissue, Cell 34: 455–466.
Damsky, C. H., Buck, C. A., and Horwitz, A. F., 1983b, Localization of a surface membrane substratum adhesion glycoprotein using a monoclonal antibody, J. Cell Biol 97: 99a.
Damsky, C. H., Richa, J., Solter, D., and Buck, C. A., 1983c, Cell-CAM 120/80; a cell—cell adhesion molecule present in the early embryo and adult epithelia, J. Cell Biol 97: 251a.
Decker, C., and Horwitz, A. F., 1982, Adhesive and morphologic hierarchies determined using a monoclonal antibody, J. Cell Biol 95: 111a.
Diaz, L. A., and Marcello, C. L., 1978, Pemphigoid and pemphigus antigens in cultured epidermal cells, Br. J . Dermatol 98: 631–637.
Ducibella, T., 1980, Divalent antibodies to mouse embryonal carcinoma cells inhibit compaction in the mouse embryo, Dey. Biol 79: 356–366.
Ducibella, T., and Anderson, E., 1975, Cell shape and membrane changes in the eight-cell mouse embryo: Prerequisites for morphogenesis of the blastocyst, Dey. Biol 47: 45–58.
Ducibella, T., Albertini, D. F., Anderson, E., and Biggers, J. D., 1975, The preimplantation mammalian embryos: Characterization of intercellular junctions and their appearance during development, Dev. Biol 45: 231–250.
Dunia, I., Nicholas, J. F., Jakob, H., Benedetti, E. L., and Jacob, F., 1979, Junctional modulation in mouse embryonal carcinoma cell serum, Proc. Natl. Acad. Sci. USA 76:3387–3391.
Edelman, G., 1983, Cell adhesion molecules, Science 219: 450–457.
Edelman, G., and Chuong, C.-M., 1982, Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice, Proc. Natl. Acad. Sci. USA 79: 7036–7040.
Edelman, G., Gallin, W. J., Delouvee, A., Cunningham, B. A., and Thiery, J.-P., 1983, Early epochal maps of two different cell adhesion molecules, Proc. Natl. Acad. Sci. USA 80: 4384–4388.
Edwards, J. G., Dysart, J., and Hughes, R. C., 1976, Cellular adhesiveness reduced in ricin-resistant hamster fibroblasts, Nature (London) 264: 66–68.
Foidart, J. M., Bere, G. W., Yaer, M., Rennard, S. I., Gullino, M., Martin, G. R., and Katz, S. I., 1980, Distribution and immunoelectron microscope localization of laminin, a non-collagenous basement membrane glycoprotein, Lab. Invest 42: 336–342.
Fox, C. H., Cottler-Fox, M. H., and Yamada, K. M., 1981, Distribution of fibronectin in attachment sites of chick fibroblasts, Exp. Cell Res 130: 477–481.
Frazier, W., and Glaser, L., 1979, Surface components and cell recognition, Annu. Rev. Biochem 48: 491–523.
Gallin, W. J., Edelman, G., and Cunningham, B., 1983, Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells, Proc. Natl. Acad. Sci. USA 80: 1038–1042.
Geiger, B., 1979, A 130K protein from gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells, Cell 18: 193–205.
Geiger, B., 1981, Involvement of vinculin in contact-induced cytoskeletal interactions, Cold Spring Harbor Symp. Quant. Biol 46: 671–682.
Geiger, B., Tokuyasu, K. T., Dutton, A. H., and Singer, S. J., 1980, Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes, Proc. Natl. Acad. Sci. USA 77: 4127–4131.
Gerisch, G., 1977, Univalent antibody fragments as tools for the analysis of cell interactions in Dictyostelium, Curr. Top. Dev. Biol 14: 243–270.
Goodman, S. R., Zagon, I. S., and Kulikowski, R., 1981, Identification of a spectrin-like protein in non-erythroid cells, Proc. Natl. Acad. Sci. USA 78: 7570–7574.
Gorbsky, G., and Steinberg, M. S., 1981, Isolation of the intercellular glycoproteins of desmosomes, J. Cell Biol 90: 243–248.
Greve, J. M., and Gottlieb, D. I., 1982, Monoclonal antibodies which alter the morphology of cultured chick myogenic cells, J. Cell. Biochem 18: 221–230.
Grinnell, F., 1978, Cellular adhesiveness and extracellular substrate, Int. Rev. Cytol 53: 65–143.
Grinnell, F., 1980, Fibroblast receptor for cell substratum adhesion: Studies on the interaction of baby hamster kidney cells with latex beads coated by cold insoluble globulin (plasma fibronectin), J. Cell Biol 86: 104–112.
Grinnell, F., 1982, Cell attachment and spreading factors, in: Growth and Maturation Factors ( G. Guroff, ed.), pp. 267–292, Wiley, New York.
Grinnell, F., and Minter, D., 1978, Attachment and spreading of baby hamster kidney cells to collagen substrata: Effect of cold insoluble globulin, Proc. Natl. Acad. Sci. USA 75: 4408–4412.
Grumet, M., Rutishauser, U., and Edelman, G. M., 1982, Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro, Nature (London) 295: 693–695.
Grunwald, G. B., Geller, R. L., and Lilien, J., 1980, Enzymatic dissection of embryonic cell adhesive mechanisms, J. Cell Biol. 85:766–776.
Grunwald, G. B., Pratt, R. S., and Lilien, J., 1982, Enzymatic dissection of embryonic cell adhesive mechanisms. III. Immunological identification of a component of the calcium-dependent adhesive system of embryonic chick neural retina cells, J. Cell Sci 55: 6987.
Harper, P. A., and Juliano, R. L., 1980, Isolation and characterization of Chinese hamster ovary cell variants defective in adhesion to fibronectin coated collagen, J. Cell Biol 87: 755–763.
Harper, P. A., and Juliano, R. L., 1981a, Fibronectin-independent adhesion of fibroblasts to the extracellular matrix: Mediation by a high molecular weight membrane glycoprotein, J. Cell Biol 91: 647–653.
Harper, P. A., and Juliano, R. L., 1981b, Two distinct mechanisms of fibroblast adhesion, Nature (London) 290: 136–138.
Hascall, V. C., and Hascall, G. K., 1981, Proteoglycans, in: Cell Biology of Extracellular Matrix ( E. D. Hay, ed.), pp. 39–64, Plenum Press, New York.
Hausman, R. E., and Moscona, A. A., 1976, Isolation of retina-specific cell-aggregating factor from membranes of embryonic neural retina tissue, Proc. Natl. Acad. Sci. USA 73: 3594–3598.
Hay, E., 1981, Extracellular matrix, J. Cell Biol 91: 205S–223S.
Hayman, E., Engvall, E., A’Hearn, E., Barnes, D., Perschbacher, M., and Ruoslahti, E., 1982, Cell attachment on replicas of SDS-polyacrylamide gel reveals two adhesive plasma proteins, J. Cell Biol 95: 20–24.
Heath, J. P., 1982, Adhesions to substratum and locomotory behavior of fibroblastic and epithelial cells in culture, in: Cell Behavior ( R. Bellairs, A. Curtis, and G. Dunn, eds.), pp. 77–103, Cambridge University Press, London.
Heath, J. P., and Dunn, G. A., 1978, Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system: A correlated interference—reflection and high-voltage electron microscope study, J. Cell Sci 29: 197–212.
Hedman, K., Kurkinen, M., Alitalo, K., Vaheri, A., Johansson, S., and Höök, M., 1979, Isolation of the pericellular matrix of human fibroblast cultures, J. Cell Biol 81: 83–91.
Hedman, K., Johansson, S., Vartio, T., Kjellén, L., Vaheri, A., and Höök, M., 1982, Structure of the pericellular matrix: Association of heparin and chondroitin sulfates with fibronectin-procollagen fibers, Cell 28: 663–671.
Hoffman, S., Sorkin, B. C., White, P. C., Brackenbury, R., Mailhammer, R., Rutishauser, U., Cunningham, R. A., and Edelman, G. M., 1982, Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes, J. Biol. Chem 257: 7720–7729.
Höök, M., Rubin, K., Oldberg, A., Öbrink, B., and Vaheri, A., 1977, Cold insoluble globulin mediates the adhesion of rat liver cells to plastic petri dishes, Biochem. Biophys. Res. Commun 79: 726–733.
Hsieh, P., and Sueoka, N., 1980, Antisera inhibiting mammalian spreading and possible cell-surface antigens involved, J. Cell Biol 86: 866–873.
Hughes, R. C., Pena, S. D., Clark, J., and Dourmashkin, R. R., 1979, Molecular requirements for the adhesion and spreading of hamster fibroblasts, Exp. Cell Res 121: 307–314.
Hull, B., and Staehelin, L. A., 1979, The terminal web, a re-evaluation of its structure and function, J. Cell Biol 81: 67–82.
Hyafil, F., Morello, D., Babinet, C., and Jacob, F., 1980, A cell-surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos, Cell 21: 927–934.
Hyafil, F., Babinet, C., and Jacob, F., 1981, Cell—cell interaction in early embryogenesis: A molecular approach to the role of calcium, Cell 26: 447–454.
Hynes, R. O., 1981a, Fibronectin and its relation to cellular structure and behavior, in: Cell Biology of Extracellular Matrix ( E. D. Hay, ed.), pp. 295–334, Plenum Press, New York.
Hynes, R. O., 1981b, Relationships between fibronectin and the cytoskeleton, in: Cytoskeletal Elements and Plasma Membrane Organization ( G. Poste and G. L. Nicolson, eds.), pp. 100–137, Elsevier/North-Holland, Amsterdam.
Hynes, R. O., and Destree, A., 1978, Relationships between fibronectin (LETS protein) and actin, Cell 15: 875–886.
Hynes, R. O., and Yamada, K. M., 1982, Fibronectins: Multifunctional modular glycoproteins, J. Cell Biol 95: 369–378.
Hynes, R. O., Destree, A. T., and Wagner, D., 1981, Relationships between microfilaments, cell—substratum adhesion and fibronectin, Cold Spring Harbor Symp. Quant. Biol 46: 659–669.
Izzard, C., and Lochner, L. R., 1976, Cell to substrate contacts in lung fibroblasts: An interference reflection study with an evaluation of the technique, J. Cell Sci 21: 129–159.
Jakoi, E. R., and Marchase, R., 1979, Ligatin from embryonic chick neural retina, J. Cell Biol 80: 624–633.
Jöhansson, E., Kjellén, L., Höök, M., and Timpl, R., 1981, Substrate adhesion of rat hepatocytes: A comparison of laminin and fibronectin as attachment proteins, J. Cell Biol 90: 260–264.
J¢rgensen, O., Steen, O., Delouvie, A., Thiery, J.-P., and Edelman, G. M., 1980, The nervous specific protein D2 is involved in adhesion assay neuritis from cultured rat ganglia, FEBS Lett. 111: 39–42.
Kemler, R., Babinet, C., Eisen, H., and Jacob, F., 1977, Surface antigens in early differentiation, Proc. Natl. Acad. Sci. USA 74: 4449–4452.
Kjellén, L., Pettersson, I., and Höök, M., 1981, Cell-surface proteoglycan: An intercalated membrane proteoglycan, Proc. Natl. Acad. Sci. USA 78: 5371–5375.
Kleinman, H., Klebe, R. J., and Martin, G. R., 1981, Role of collagenous matrices in the adhesion and growth of cells, J. Cell Biol 88: 473–487.
Knox, P., and Griffiths, S., 1979, A cell-spreading factor in human serum that is not cold insoluble globulin, Exp. Cell Res 123: 421–424.
Knudsen, K. A., Rao, P. E., Damsky, C. H., and Buck, C. A., 1981, Membrane glycoproteins involved in cell—substratum adhesion, Proc. Natl. Acad. Sci. USA 78: 6071–6075.
Knudsen, K. A., Damsky, C. H., and Buck, C. A., 1982a, Expression of adhesion-related membrane components in adherent versus non-adherent hamster melanoma cells, J. Cell. Biochem 18: 157–167.
Knudsen, K. A., Buck, C. A., Damsky, C. H., and Horwitz, A. F., 1982b, Adhesion-related glycoproteins isolated using a monoclonal antibody, J. Cell Biol 95: 111a.
Knudsen, K. A., Buck, C. A., and Horwitz, A. F., 1983, Characterization of cell-matrix adhesion-related integral membrane glycoproteins, J. Cell Biol 97: 99a.
Lahav, J., Schwartz, M. A., and Hynes, R. O., 1982, Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen, Cell 31: 253–262.
Laterra, J., Silbert, J. E., and Culp, L. A., 1983, Cell-surface heparan sulfate mediates some adhesive responses to glycosaminoglycan binding matrices including fibronectin, J. Cell Biol 96: 112–123.
Lehto, V.-P., 1983, 140,000 dalton surface glycoprotein: A plasma membrane component of the detergent resistant cytoskeletal preparations of cultured human fibroblasts, Exp. Cell Res 143: 272–286.
Lehto, V.-P., Vartio, T., and Virtanen, I., 1980, Enrichment of a 140-kd surface glycoprotein in adherent, detergent-resistant cytoskeletons of cultured human fibroblasts, Biochem. Biophys. Res. Commun 95: 909–916.
Lehto, V.-P., Vartio, T., and Virtanen, I., 1981, Persistence of a 140,000 Mr surface glycoprotein in cell-free matrices of cultured human fibroblasts, FEBS Lett. 124: 289–292.
Lehto, V.-P., Vartio, T., Badley, R. A., and Virtanen, I., 1983, Characterization of a detergent-resistant surface lamina in cultured human fibroblasts, Exp. Cell Res 143: 287–295.
Lilien, J., Balsamo, J., McDonough, J., Hermolin, J., Cook, J., and Rutz, R., 1979, Adhesive specificity among embryonic cells, in: Surfaces of Normal and Malignant Cells ( R. O. Hynes, ed.), pp. 389–419, Wiley, New York.
Luna, E. J., Fowler, V., Swanson, J., Branton, D., and Taylor, D. L., 1981, Membrane cytoskeleton from Dictyostelium discoideum. I. Identification and partial characterization of an actin binding activity, J. Cell Biol 88: 396–409.
McClain, D., and Edelman, G., 1982, A neural cell adhesion molecule from human brain, Proc. Natl. Acad. Sci. USA 79: 6380–6384.
McClay, D. R., Wessel, G. M., and Marchase, R. B., 1980, Intercellular recognition: Quantitation of initial binding events, Proc. Natl. Acad. Sci. USA 78: 4975–4979.
McPherson, J., Sage, H., and Bornstein, P., 1981, Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture: Apparent identity with platelet thrombospondin, J. Biol. Chem 256: 11330–11336.
Madri, J. A., Roll, F. J., Furthmayr, H., and Foidart, J.-M., 1980, Ultrastructural localization of fibronectin and laminin in the basement membrane of the murine kidney, J. Cell Biol 86: 682–687.
Magnani, J. L., Thomas, W. A., and Steinberg, M. S., 1981, Two distinct adhesion mechanisms in embryonic neural retina cells, Dev. Biol 81: 96–105.
Malinoff, H. L., and Wicha, M. S., 1983, Isolation of a cell surface receptor for a laminin from murine fibrosarcoma cells, J. Cell Biol 96: 1475–1479.
Marchase, R. B., Koro, L. A., Kelly, C. M., and McClay, D. R., 1982, Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucose, Cell 28: 813–820.
Matsudaira, P. T., and Burgess, D. R., 1981, Structure and function of brush border cytoskeleton, Cold Spring Harbor Symp. Quant. Biol 46: 845–854.
Mayer, B. W., Hay, E., and Hynes, R. O., 1981, Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa, Dev. Biol 82: 267–286.
Mollenhauer, J., and van der Mark, K., 1983, Isolation and characterization of a collagenbinding glycoprotein from chondrocyte membrane, EMBO J. 2: 45–50.
Moscona, A. A. (ed.), 1974, in: Cell Surface in Development; Surface specification of embryonic cells: lectin receptors, cell recognition and specific cell ligands. pp. 67–99, Wiley, New York.
Neff, N. T., Lowrey, C., Decker, C., Tovar, A., Damsky, C., Buck, C., and Horwitz, A. F., 1982, A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices, J. Cell Biol 95: 654–666.
Newgreen, D., and Thiery, J.-P., 1980, Fibronectin in early avian embryos: Synthesis and distribution along the migration pathways of neural crest cells, Cell Tissue Res. 211: 269–291.
Nicolas, J.-F., Kemler, R., and Jacob, F., 1981, Effects of anti-embryonal carcinoma serum on aggregation and metabolic cooperation between teratocarcinoma cells, Dev. Biol 81: 127–132.
Nielsen, L. D., Pitts, M., Grady, S. R., and McGuire, E. J., 1981, Cell—cell adhesion in the embryonic chick: Partial purification of liver adhesion molecules from liver membranes, J. Cell Biol 86: 315–326.
Ocklind, C., and Öbrink, B., 1982, Intercellular adhesion of rat hepatocytes: Identification of a cell-surface glycoprotein involved in the initial adhesion process, J. Biol. Chem 257: 6788–6795.
Ocklind, C., Forsum, U., and Öbrink, B., 1983, Cell-surface localization and tissue distribution of a hepatocyte cell—cell adhesion glycoprotein (cell-CAM 105), J. Cell Biol 96: 1168–1171.
Ogou, S.-I., Yashida-Noro, C., and Takechi, M., 1983, Calcium dependent cell—cell adhesion molecules common to hepatocytes and teratocarcinoma stem cells, J. Cell Biol 97: 944–948.
Oesch, B., and Birchmeier, W., 1982, New surface component of fibroblasts focal contacts identified by a monoclonal antibody, Cell 31: 671–679.
Oppenheimer-Marks, N., and Grinnell, F., 1982, Inhibition of fibronectin receptor function by antibodies against BHK wheat germ agglutinin receptors, J. Cell Biol 95: 876–884.
Oppenheimer-Marks, N., Marshall, J., and Grinnell, F., 1982, Cell surface glycoproteins in fibronectin receptor function, J. Cell Biol 95: 246a.
Pena, S. D. J., Mills, G., and Hughes, R. C., 1979, Two-dimensional electrophoresis of surface glycoproteins of normal BHK cells and ricin-resistant mutants, Biochim. Biophys. Acta 550: 100–109.
Pouyssegur, J., and Pastan, I., 1977, Mutants of mouse fibroblasts altered in the synthesis of cell-surface glycoproteins, J. Biol. Chem 252: 1639–1646.
Rapraeger A. C., and Bernfield, M., 1983a, Heparan sulfate proteoglycan from mouse mammary epithelial cells: A putative membrane proteoglycan associates quantitatively with lipid vesicles, J. Biol. Chem 258: 3632–3636.
Rapraeger, A. C., and Bernfield, M., 1982, An integral membrane proteoglycan is capable of binding components of the cytoskeleton and the extracellular matrix, 14th Michigan Molecular Institute Symposium: Extracellular Matrix (S. Hawkes and J. L. Wang, eds.), p. 265–270, Academic Press, New York.
Rees, D. A., Badley, R. A., Bayley, S. A., Couchman, J. R., Smith, C. G., and Woods, A., 1981, Surface components in fibroblast adhesion and movement, in: Cellular Interactions (J. T. Dingle and J. L. Gordon, eds.), pp. 67–80, Elsevier/North-Holland, Amsterdam.
Revel, J., and Wolken, K., 1973, Electron microscope investigation of the underside of cells in culture, Exp. Cell Res 78: 1–14.
Rollins, B. S., Cathcart, M. K., and Culp, L. A., 1982, Fibronectin—proteoglycan binding as the molecular basis for fibroblast adhesion to extracellular matrices, in: Glycoconjugates, Vol. III ( M. Horowitz, ed.), pp. 289–329, Academic Press, New York.
Rorschneider, L., Rosok, M., and Shriver, K., 1981, Mechanism of transformation by Rous sarcoma virus: Events within adhesion plaques, Cold Spring Harbor Symp. Quant. Biol 46: 953–967.
Roth, S., 1983, Biochemistry of cell adhesion in vertebrates, in: Cell Interactions and Development: Molecular Mechanisms ( K. Yamada, ed.), pp. 77–98, John Wiley & Sons Inc., New York, New York.
Rothbard, J. B., Brackenbury, R., Cunningham, B., and Edelman, G. M., 1982, Differences in the carbohydrate structure of neural cell adhesion molecule from adult and embryonic chicken brain, J. Biol. Chem 257: 11064–11069.
Rubin, K., Höök, M., Öbrink, B., and Timpl, R., 1981, Substrate adhesion of rat hepatocytes: Mechanism of attachment to collagen substrates, Cell 24: 463–470.
Ruoslahti, E., Engvall, E., and Hayman, E. G., 1981, Fibronectin: Current concepts of structure and function, Cell Res. 1: 1–36.
Rutishauser, U., Thiery, J.-P., Brackenbury, R., Sela, B.-A., and Edelman, G., 1976, Mechanisms of adhesion among cells from the neural tissues of the chick embyro, Proc. Natl. Acad. Sci. USA 73: 577–581.
Rutishauser, U., Thiery, J.-P., Brackenbury, R., and Edelman, G. M., 1978a, Adhesive assay neural cells of the chick embyro. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns, J. Cell Biol 79: 371–381.
Rutishauser, U., Gall, W. E., and Edelman, G. M., 1978b, Adhesion among neural cells of the chick embryo. IV. Role of cell surface molecule CAM in the formation of neurite bundles in culture of spinal ganglia, J. Cell Biol 79: 382–393.
Rutishauser, U., Hoffman, S., and Edelman, G. M., 1982, Binding properties of a cell- adhesive molecule from neural tissue, Proc. Natl. Acad. Sci. USA 79: 685–689.
Rutishauser, U., Grumer, M., and Edelman, G., 1983, Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture, J. Cell Biol 97: 145–152.
Schor, S., and Court, J., 1979, Different mechanisms in the attachment of cells to native and denatured collagen, J. Cell Sci 38: 267–281.
Schubert, D., and La Courbiere, M., 1982, Properties of extracellular adhesion-mediating particles in a myoblast clone and its adhesion-deficient variant, J. Cell Biol 94: 108–114.
Schwartz, M. A., Das, O. P., and Hynes, R. O., 1982, A new radioactive crosslinking reagent for studying the interactions of proteins, J. Biol. Chem 257: 2343–2349.
Singer, I., 1979, The fibronexus: A transmembrane association of fibronectin-containing fibers and bundles of 5-µm microfilaments in hamster and human fibroblasts, Cell 16: 675–685.
Singer, I. I., 1982, Association of fibronectin and vinculin with focal contacts and stress fibers in stationary hamster fibroblasts, J. Cell Biol 92: 398–409.
Solter, D., and Knowles, B. B., 1975, Immunosurgery of mouse blastocysts, Proc. Natl. Acad. Sci. USA 72: 5099–5102.
Staehelin, L. A., 1974, Structure and function of intercellular junctions, Int. Rev. Cytol 39: 191–283.
Stanley, J. R., Alvarez, O. M., Bere, E. W., Eaglestein, W. H., and Katz, S. I., 1981a, Detection of basement membrane zone antigens during epidermal wound healing in pigs, J. Invest. Dermatol 77: 240–243.
Stanley, J. R., Hawley-Nelson, P., Yuspa, S. H., Shevach, E. M., and Katz, S. I., 1981b, Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia, Cell 24: 897–903.
Steinberg, M., 1978, in: Cell—cell recognition in multicellular assembly: levels of assembly, Soc. Exp. Biol. Symp XXXII: 25–29.
Sugrue, S. P., and Hay, E., 1982, Interaction of embryonic corneal epithelium with exogenous collagen, laminin and fibronectin: role of endogenous protein synthesis, Dev. Biol 92: 97–106.
Takeichi, M., 1977, Functional correlation between cell adhesive properties and some cell-surface proteins, J. Cell Biol 75: 464–474.
Takeichi, M., Ozaki, H. S., Takunaga, K., and Okada, T. S., 1979, Experimental manipulation of the cell surface to affect cellular recognition mechanisms, Dev. Biol 70: 195–205.
Takeichi, M., Atsumi, J., Yoshida, K. U., and Okada, T. S., 1981, Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca’ -dependent sites, Dev. Biol 87: 340–350.
Tarone, G., Galletto, G., Prat, M., and Comoglio, P., 1982, Cell-surface molecules and fibronectin mediated cell adhesion: Effect of proteolytic digestion of membrane proteins, J. Cell Biol 94: 179–186.
Thiery, J.-P., Brackenbury, R., Rutishauser, U., and Edelman, G. M., 1977, Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina, J. Biol. Chem 252: 6841–6845.
Thiery, J.-P., Duband, J.-L., Rutishauser, U., and Edelman, G. M., 1982, Cell adhesion molecules in early chicken embryogenesis, Proc. Natl. Acad. Sci. USA 79: 6737–6741.
Thomas, W. A., and Steinberg, M. S., 1981, Two distinct adhesion mechanisms in embryonic neural retina cells. II. An immunological analysis, Dey. Biol 81: 106–114.
Tokuyasu, K. T., and Singer, S. J., 1976, Improved procedures for immunoferritin labeling of ultra-thin frozen sections, J. Cell Biol 71: 894–906.
Urushihara, H., and Takeichi, M., 1980, Cell—cell adhesion molecule: Identification of a glycoprotein relevant to the Ca’ -independent aggregation of Chinese hamster fibroblasts, Cell 20: 363–371.
Urushihara, H., Ueda, M. J., Ockeda, T. S., and Takeichi, M., 1977, Calcium-dependent and independent adhesion of normal and transformed BHK cells, Cell Struct. Funct 2: 289–296.
Urushihara, H., Ozaki, H. S., and Takeichi, M., 1979, Immunological detection of cell-surface components related with aggregations of Chinese hamster and chick embryonic cells, Dey. Biol 70: 206–216.
Virtanen, I., Vartio, T., Badley, R. A., and Lehto, V.-P., 1982, Fibronectin in adhesion, spreading and cytoskeletal organization of cultured fibroblasts, Nature (London) 298: 660–663.
Vollmers, H. P., and Birchmeier, W., 1983, Monoclonal antibodies inhibit the adhesion of mouse B16 melanoma cells in vitro and block lung metastasis in vivo, Proc. Natl. Acad. Sci. USA 80: 3729–3733.
Wehland, J., Osborn, M., and Weber, K., 1979, Cell to substratum contacts in living cells: A direct correlation between interference reflection and indirect immunofluorescence microscopy using antibodies against a-actinin, J. Cell Sci 37: 257–273.
Wylie, D. E., Damsky, C. H., and Buck, C. A., 1979, Studies on the function of cell-surface glycoproteins. I. Use of antisera to surface membranes in the identification of membrane components relevant to cell—substrate adhesion, J. Cell Biol 80: 385–402.
Yamada, K. M., 1981, Fibronectin and other structural proteins, in: Extracellular Matrix ( E. D. Hay, ed.), pp. 95–114, Plenum Press, New York.
Yamada, K. M., 1983, Cell-surface interactions with extracellular materials, Annu. Rev. Biochem 52: 761–800.
Yamada, K. M., and Olden, K., 1978, Fibronectin: Adhesive glycoproteins of the cell surface and blood, Nature (London) 275: 179–184.
Yoshida, C., and Takeichi, M., 1982, Teratocarcinoma cell adhesion: Identification of a cell surface protein involved in calcium-dependent cell aggregation, Cell 28: 217–224.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Damsky, C.H., Knudsen, K.A., Buck, C.A. (1984). Integral Membrane Glycoproteins in Cell-Cell and Cell-Substratum Adhesion. In: Ivatt, R.J. (eds) The Biology of Glycoproteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7464-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7464-0_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7466-4
Online ISBN: 978-1-4684-7464-0
eBook Packages: Springer Book Archive