Skip to main content

Intracellular Mechanisms Regulating Intestinal Secretion

  • Chapter
Book cover Molecular Pathogenesis of Gastrointestinal Infections

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 58))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H.R. de Jonge and S.M. Lohmann, Mechanisms by which cyclic nucleotides and other intracellular mediators regulate secretion. Ciba Found. Svmp. 112:116 (1985).

    Google Scholar 

  2. H.R. de Jonge and M.C. Rao, Role of cAMP- and cGMP-dependent protein kinase in epithelial transport, in: “Pathophysiology of Secretory Diarrhoea”, M. Duffey and E. Lebenthal, eds., Raven Press, New York, in the press (1990).

    Google Scholar 

  3. M. Field, M.C. Rao and E.B. Chang, Intestinal electrolyte transport and diarrheal disease (parts I and II) N. Engl. J. Med. 321:800 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. M. Field, M.C. Rao and E.B. Chang, Intestinal electrolyte transport and diarrheal disease (parts I and II) N. Engl. J. Med. 321: 879 (1989).

    Article  PubMed  CAS  Google Scholar 

  5. D.W. Landry, M.H. Ekabas, C. Redhead, A. Edelman, E.J. Cragoe, and Q. Al-Awqati, Purification and reconstitution of chloride channels from kidney and trachea, Science 244:1469 (1989).

    Article  PubMed  CAS  Google Scholar 

  6. T.C. Hwang, S.E. Guggino and W.B. Guggino, Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids, Proc. Natl. Acad. Sci. U.S.A. 87:5706 (1990).

    Article  PubMed  CAS  Google Scholar 

  7. H.R. de Jonge, A.G.M. Bot and A.B. Vaandrager, Mechanism of action of E. coli heat-stable enterotoxin, in: “Bacterial Protein Toxins”, Zentralblatt f. Bact. Microbiol, u. Hygiene Suppl. 15:34 (1986).

    Google Scholar 

  8. M. Donowitz, M.E. Cohen, M. Gould and G.W.G. Sharp, Elevated intracellular Ca acts through protein kinase C to regulate rabbit leal NaCl absorption, J. Clin. Invest. 83:1953 (1989).

    Article  PubMed  CAS  Google Scholar 

  9. A.B. Vaandrager, M.C. Ploemacher and H.R. de Jonge, Polyphosphoinositide metabolism in intestinal brush borders: stimulation of IP3 formation by guanine nucleotides and Ca2+, Am. J. Phvsiol. 259, in the press (1990).

    Google Scholar 

  10. M.M. Billah and J.C. Anthes, The regulation and cellular functions of phosphatidylcholine hydrolysis, Biochem. J. 269:281 (1990).

    PubMed  CAS  Google Scholar 

  11. H.R. de Jonge, N. van den Berghe, B.C. Tilly, M. Kansen and J. Bijman, (Dys) regulation of epithelial chloride channels. Biochem. Soc. Transact. 17:816 (1989).

    Google Scholar 

  12. N.J. Willumsen and R.C. Boucher, Activation of an apical Cl- conductance by Ca2+-ionophore in cystic fibrosis airway epithelia, Am. J. Phvsiol. 256:C226 (1989).

    CAS  Google Scholar 

  13. H.R. de Jonge, J. Bijman and M. Sinaasappel, Relation of regulatory enzyme levels to chloride transport in intestinal cells, Ped. Pulmonol. (Suppl.) 1:54 (1987).

    Google Scholar 

  14. C.J. Taylor, P.S. Baxter, J. Hardcastle and P.T. Hardcastle, Failure to induce secretion in jejunal biopsies from children with cystic fibrosis, Gut 29:957 (1989).

    Article  Google Scholar 

  15. H.M. Berschneider, M.R. Knowles, R.G. Azizkhan, R.C. Boucher, N.A. Tobey, R.C. Orlando and D.W. Powell, Altered intestinal chloride transport in cystic fibrosis, FASEB J. 2:2625 (1988).

    PubMed  CAS  Google Scholar 

  16. J.M. Rommens et al., Identification of the cystic fibrosis gene: chromosome walking and jumping, Science 245:1059 (1989).

    Article  PubMed  CAS  Google Scholar 

  17. J.R. Riordan et al., Identification of the cystic fibrosis gene: cloning and characterization of the complemantary DNA, Science 245:1066 (1989).

    Article  PubMed  CAS  Google Scholar 

  18. A.T. Hoogeveen, J. Keulemans, R. Willemsen, B.J. Scholte, J. Bijman, H. Galjaard, M.J. Edixhoven and H.R. de Jonge, Immunological identification of 155 and 195 kDa proteins as candidates for the products of the cystic fibrosis gene, Nature, submitted.

    Google Scholar 

  19. D. Ringe and G.A. Petsko, A transport problem? Nature 346:312 (1990).

    Article  PubMed  CAS  Google Scholar 

  20. B.C. Tilly, M. Kansen, P.G.M. van Gageldonk, N. van den Berghe, J. Bijman and H.R. de Jonge, Activation of intestinal chloride channels by GTP-binding regulatory proteins, in: “Advances in Second Messengers and Phosphorylation Research”, Y. Nishizuka, ed., 24:95 (1990).

    Google Scholar 

  21. B.C. Tilly, M. Kansen, P.G.M. van Gageldonk, N. van den Berghe and H.R. de Jonge, Activation of intestinal chloride channels by GTP-binding G-proteins mediate intestinal chloride channel activation, J. Biol. Chem., submitted.

    Google Scholar 

  22. D.B. Light, D.A. Ausiello and B.A. Stanton, Guanine nucleotide-binding protein, α*1–3, directly activates a cation channel in rat renal inner medullary collecting duct cells. J. Clin. Invest. 84:352 (1989).

    Article  PubMed  CAS  Google Scholar 

  23. E.M. Schwiebert, D.B. Light, G. Fejes-Toth, A. Naray-Fejes-Toth and B.A. Stanton, A GTP-binding protein activates chloride channels in a renal epithelium, J. Biol. Chem. 265:7725 (1990).

    PubMed  CAS  Google Scholar 

  24. D.A. Ausiello, CR. Patenande and H.F. Cantiello, G-protein activation of epithelial Na+ channels is mediated via phospholipid metabolites, Proc. Int. Workshop on the CF gene. Sestri Levante, April 9–11, abstract (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

de Jonge, H.R. (1991). Intracellular Mechanisms Regulating Intestinal Secretion. In: Wadström, T., Mäkelä, P.H., Svennerholm, AM., Wolf-Watz, H. (eds) Molecular Pathogenesis of Gastrointestinal Infections. Federation of European Microbiological Societies Symposium Series, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5982-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5982-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5984-5

  • Online ISBN: 978-1-4684-5982-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics