Abstract
Glutathione plays a critical role in the maintenance of reduced thiol groups in the cell and is of particular importance in the biosynthesis of DNA [for a review, see Holmgren, 1985]. Glutathione itself is maintained in a reduced form at the expense of NADPH by the action of the enzyme glutathione reductase (EC 1.6.4.2):
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Perham, R.N., Berry, A., Scrutton, N.S., Deonarain, M.P. (1989). Site-Directed Mutagenesis and the Mechanism of Flavoprotein Disulphide Oxidoreductases. In: Jardetzky, O., Holbrook, R. (eds) Protein Structure and Engineering. NATO ASI Series, vol 183. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5745-2_21
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