Abstract
The ovary has many similarities to other “renewal tissues” in adults. Renewal tissues are those in which differentiated, functional cells are continuously being replaced by proliferation of more primitive cells. These tissues are composed of a hierarchy of cells: at one end of the hierarchy are stem cells which are less differentiated and can divide without limit; at the other end are mature cells which are highly differentiated and have no capacity for proliferation (Mackillop et al., 1983). When a stem cell divides, each daughter cell has a choice: it can either remain a stem cell, or it can embark on a course of “clonal expansion” leading irreversibly to terminal differentiation (Fig 1). Daughter cells which embark on the second course are known as “transitional cells (Selby et al., 1983) or “committed progenitor cells” (Fitchen et al., 1981). Transitional cells have a limited capacity for cell division. They exhibit a continuous gradient of properties along a unidirectional vector; as cells move down the hierarchy, they acquire the differentiated features associated with specific tissue function, and they progressively lose the potential to divide (Mackillop et al., 1983). The more highly differentiated progeny greatly outnumber the less differentiated progenitor cells within the tissue.
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References
Adashi EY, Hsueh AJW, 1981. Stimulation of B-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology 108:2170–2178
Aguado LI, Ojeda SR, 1984. Prepubertal ovarian function is finely regulated by direct adrenergic influences: role of noradrenergic innervation Endocrinology 114:1845–1853
Amsterdam A, Lindner HR, Groschel-Stewart U, 1976. Localization of actin and myosin in the rat oocyte and follicular wall by immunofluorescence Anat Rec 187:311–328
Arendsen de Wolff-Exalto E, 1982. Influence of gonadotrophins on early follicle cell development and early oocyte growth in the immature rat J Reprod Fertil 66:537–542
Bassett DL, 1943. The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle. Am J Anat 73:251–291
Bogovich K, Richards JS, 1984. Androgen synthesis during follicular development: evidence that rat granulosa cell 17-ketosteroid reductase is independent of hormonal regulation. Biol Reprod 31:122–131
Bogovich K, Richards JS, Reichert LE, 1981. Obligatory role of luteinizing hormone (LH) in the initiation of preovulatory follicular growth in the pregnant rat: specific effects of hCG and FSH on LH receptors and steroidogenesis in theca and granulosa cells. Endocrinology 109:860–867
Bortolussi M, Marini G, Dal Lago A, 1977. Autoradiographic study of the distribution of LH(hCG) receptors in the ovary of untreated and gonadotrophin-primed immature rats. Cell Tissue Res 183:329–342
Bortolussi M, Marini G, Reolon ML, 1979. A histochemical study of the binding of 1251-hCG to the rat ovary throughout the estrous cycle Cell Tissue Res 197:213–226
Braw RH, Tsafriri A, 1980. Follicles explanted from pentobarbitone-treated rats provide a model for atresia. J Reprod Fertil 59:259–265
Brown G, Bunce CM, Guy GR, 1985. Sequential determination of lineage potentials during haemopoiesis Br J Cancer 52:681–686
Brown-Grant K, Exley D, Naftolin F, 1970. Peripheral plasma oestradiol and luteinizing hormone concentrations during the oestrous cycle of the rat. J Endocrinol 48:2 95–2 96
Bryant-Greenwood GD, Jeffrey R, Ralph MM, Seamark RF, 1980. Relaxin production by the porcine ovarian Graafian follicle in vitro. Biol Reprod 23:792–800
Butcher RL, Collins WE, Fugo NW, 1974. Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17B throughout the four-day estrous cycle of the rat. Endocrinology 94:1704–1708
Byskov AGS, 1978. “Follicular Atresia”. In: Jones RE (ed.), The Vertebrate Ovary NY Plenum Press pp. 533–562
Byskov AGS, Lintern-Moore S, 1973. Follicle formation in the immature mouse ovary: the role of the rete ovarii. J Anat 116:207–217
Byskov AG, Hoyer PE, Westergaard L, 1985. Origin and differentiation of the endocrine cells of the ovary. J Reprod Fertil 75: 299–306
Canipari R, Strickland S, 1986. Studies on the hormonal regulation of plasminogen activator production in the rat ovary. Endocrinology 118: 1652–1659
Carson R, Smith J, 1986. Development and steroidogenic activity of preantral follicles in the neonatal rat ovary. J Endocrinol 110:87–92
Carson RS, Richards JS, Kahn LE, 1981. Functional and morphological differentiation of theca and granulosa cells during pregnancy in the rat: dependence on increased basal luteinizing hormone. Endocrinology 109:1433–1441
Chabot JG, St. Arnaud R, Walker P, Pelletier G, 1986. Distribution of epidermal growth factor receptors in the rat ovary. Mol Cell Endocrinol 44:99–108
Chang SCS, Ryan RJ, Kang YH, Anderson WA, 1978. Some observations on the development and function of ovarian follicles. In Sreenan JR (ed.), Control of Reproduction in the Cow. The Hauge, Martinus Nijhoff, pp. 3–33
Costlow ME, McGuire WL, 1977. Autoradiographic localization of the binding of 125I-labelled prolactin to rat tissues in vitro. J Endocrinol 75: 221–226
Cunha GR, Chung LWK, Shannon JM, Taguchi O, Fuji H, 1983. Hormone-induced morphogenesis and growth: role of mesenchymal-epithelial interactions Rec Prog Hor Res 39:559–598
Daniel SAJ, Armstrong DT, 1984. Site of action of androgens on FSH-induced aromatase activity in cultured rat granulosa cells. Endocrinology 114:1975–1982
DePaolo LV, Wise PM, Anderson LD, Barraclough CA, Channing CP, 1979. Suppression of the pituitary follicle-stimulating hormone secretion during proestrus and estrus in rats by porcine follicular fluid: possible site. Endocrinology 104:402–408
DePaolo LV, Shander D, Wise PM, Barraclough CA, Channing CP, 1979. Identification of inhibin-like activity in ovarian venous plasma of rats during the estrous cycle. Endocrinology 105:647–658
Dubreuil G, 1948. Sur l’existence d’une substance inductrice a action limitee et locale pour la metaplasie thecale des cellules du stroma cortical ovarien. Ann Endocrinol 9:434–442
Erickson GF, Hsueh AJW, 1978. Induction of aromatase activity by follicle stimulating hormone in rat granulosa cells in vivo and in vitro Endocrinology 102:1275–1282
Erickson GF, Magoffin DA, Dyer CA, Hofeditz C, 1985. The ovarian androgen producing cells: a review of strueture/function relationships Endocrinol Rev 6:371–399
Eshkol A, Lunenfeld B, 1972. Gonadotropic regulation of ovarian development in mice during infancy. In: Saxena BB, Beling CG, Gandy HM, (eds.), The Gonadotropins. New York, John Wiley and Sons, pp. 335–346
Familiari G, Correr S, Motta PM, 1981. Gap junctions in theca interna cells of developing and atretic follicles Adv Morph Cells and Tissue 11th Intl Congress, pp. 337–348
Fitchen JH, Foon KA, Cline MJ, 1981. The antigenic characteristics of hematopoietic stem cells. New Eng J Med 305:17–25
Fox H 1985. Sex cord-stromal tumours of the ovary. J Path 145:127–148
Goldenberg RL, Reiter EO, Ross GT, 1973. Follicle response to exogenous gonadotropins: an estrogen-mediated phenomenon. Fertil Steril 24: 121–127
Guraya SS, Greenwald GS, 1964. Histochemical studies on the interstitial gland in the rabbit ovary. Am J Anat 114:495–520
Guraya SS, Greenwald GS, 1964. A comparative histochemical study of interstitial tissue and follicular atresia in the mammalian ovary. Anat Rec 149:411–434
Hage AJ, Groen-Klevant AG, and Welschen R, 1978. Follicle growth in the immature rat ovary. Acta Endocrinol 88:375–382
Hillier SG, DeZwart FA, 1981. Evidence that granulosa cell aromatase induction/activation by FSH is an androgen receptor-regulated process in vitro. Endocrinology 109:1303–1305
Hirshfield AN, 1982. Follicular recruitment in long-term hemicastrate rats. Biol Reprod 27:48–53
Hirshfield AN, 1983. Compensatory ovarian hypertrophy in the long-term hemicastrate rat: size distribution of growing and atretic follicles Biol Reprod 28:271–277
Hirshfield AN, 1984. Stathmokinetic analysis of granulosa cell proliferation in antral follicles of cyclic rats. Biol Reprod 31: 52–58
Hirshfield AN, 1985. Patterns of Cell Proliferation in Follicles Approaching Ovulation: In Toft DO, Ryan RJ (eds.), Proceedings of the Fifth Ovarian Workshop. IL Ovarian Workshops, Inc., pp.249–253
Hirshfield AN, 1985. Comparison of granulosa cell proliferation in small follicles of hypophysectomized, prepubertal and mature rats. Biol Reprod 32:979–987
Hirshfield AN, 1986. Effect of a low dose of pregnant mare’s serum gonadotropin on follicular recruitment and atresia in cycling rats Biol Reprod 35:113–118
Hirshfield AN, Midgley AR, 1978. Morphometric analysis of follicular development in the rat. Biol Reprod 19:597–605
Hirshfield AN, DePaolo LV, 1981. Effect of suppression of the surge of follicle stimulating hormone with porcine follicular fluid on follicular development in the rat. J Endocrinol 88:67–71
Hisaw FI 1947. Development of the Graafian follicle and ovulation Physiol Rev 27:95–119
Hoak DC, Schwartz NAB, 1980. Blockade of recruitment of ovarian follicles by suppression of the secondary surge of follicle-stimulating hormone with porcine follicular fluid. PNAS(USA) 77:4953–4956
Hunzicker-Dunn M, Jungmann RA, Evely L, Hadawi GL, Maizels ET, West, 1984. Modulation of soluble ovarian adenosine 3,5-monophosphate-dependent protein kinase activity during prepubertal development of the rat. Endocrinol 115:302–311
Kang Y, 1974. Development of the zona pellucida in the rat oocyte. Am J Anat 139:535–566
Kent J, Ryle M, 1975. Histochemical studies on three gonadotrophin-responsive enzymes in the infantile mouse ovary. J Reprod Fértil 42: 519–536
Koos RD, Le Maire WD, 1983. Evidence for an angiogenic factor in rat follicles: In Greenwald GS, Terranova PF (eds.), Factors Regulating Ovarian Function. NY Raven Press, pp. 191–196
LaPolt SPS, Matt DW, Shryne JE, Lu JHK, 1985. Analysis of ovarian follicular dynamics in aged and young female rats using continuous 3H-TdR infusion. Endocrine Society Abstract #924.
Lacker HM, Beers WH, Meuli LE, Atkin E, 1987. A theory of follicle selection. Biol Reprod (in press)
Lajtha LG, 1983. Stem cell concepts: In: Potten CS (ed.), Stem Cells: Their Identification and Characterization. Edinburgh Churchill, Livingstone, pp. 1–11
Lintern-Moore S, Everitt AV, 1978. The effect of restricted food intake on the size and composition of the ovarian follicle population in the Wistar rat. Biol Reprod 19:688–691
Lintern-Moore S, Moore GPM, 1979. The initiation of follicle and oocyte growth in the mouse ovary. Biol Reprod 20:773–778
Lintern-Moore S, Pantelouris EM, 1976. Ovarian development in athymic nude mice IV. the effect of PMSG and oestradiol on the growth of the oocyte and follicle. Mech Aging and Devel 5:155–162
Louvet J-P, Harman SM, Schreiber JR, Ross GT, 1975. Evidence for a role of androgens in follicular maturation. Endocrinology 97:366–372
Lu JHK, LaPolt PS, Nass TC, Matt DW, Judd HL, 1985. Relation of circulating estradiol and progesterone to gonadotropin secretion and es-trous cyclicity in aging female rats. Endocrinology 116:1953–1959
Lunenfeld B, Kraiem Z, Eshkol A, 1975. The function of the growing follicle J Reprod Fertil 45:567–574
Mackillop WJ, Ciampi A, Till JE, Buick RN, 1983. A stem cell model of human tumor growth: implications for tumor cell clonogenic assays JNCI 70: 9–16
Maurer HR, 1981. Potential pitfalls of [3H] thymidine techniques to measure cell proliferation. Cell Tissue Kinet 14:111–120
May JV, Schomberg DW, 1981. Granulosa cell differentiation in vitro: the effect of insulin on growth and final integrity Biol Reprod 25: 421–431
McLeod BJ, Haresign W, 1984. Evidence that progesterone may influence subsequent luteal function in the ewe by modulating preovulatory follicle development. J Reprod Fertil 71:381–386
Merchant H, 1975. Rat gonadal and ovarian organogenesis with and without germ cells, an ultrastructural study. Develop Biol 44:1–21
Merchant-Larios H, 1979. Origin of the somatic cells in the rat gonad: an autoradiographic approach. Ann Biol anim Bioch Biophys 19:1219–1229
Moore GPM, Lintern-Moore S, Peters H, and Faber M, 1974. RNA synthesis in the mouse oocyte. Cell Biol 60:416–422
Mueller PL, Schreiber JR, Lucky AW, Schulman JD, Rodbard D, Ross GT, 1978. Follicle stimulating hormone stimulates ovarian synthesis of proteoglycans in the estrogen-stimulated hypophysectomized immature female rat. Endocrinology 102:824–831
Nicosia SV, Tojo R, 1979. Morphogenetic reaggregation and luteinization of mouse preantral follicle cells Am J Anat 156:401
Nimrod A, Erickson GF, Ryan KJ, 1976, A specific FSH receptor in rat granulosa cells: properties of binding in vitro. Endocrinology 98: 56–64
O’Shea JD, 1970. An ultrastructural study of smooth muscle-like cells in the theca externa of ovarian follicles in the rat. Anat Rec 167: 127–131
Oakberg EF, 1979. Timing of oocyte maturation in the mouse and its relevance to radiation-indueed cell killing and mutational sensitivity. Mutat Res 59:39–48
Oakberg EF, Tyrrell PD, 1975. Labelling of the zona pellucida of the mouse oocyte. Biol Reprod 12:477–482
Ohno S, Smith JB, 1964. Role of fetal follicular cells in meiosis of mammalian oocytes. Cytogenetics 3:324–333
Parkening TA, Collins TJ, Elder FFB, 1985. Othotopic ovarian transplantation in young and aged C5BL/6J mice. Biol Reprod 32: 989–997
Pedersen T, 1969. Follicle growth in the immature mouse ovary Acta Endocrinol 62:117–132
Pedersen T, 1970a. Follicle kinetics in the ovary of the cyclic mouse Acta Endocrinol 64:304–323
Pedersen T, 1970b. Cell population kinetics of the ovary of the immature mouse after FSH stimulation. In: Butt WR, Crooke AC, Ryle M (eds.), Gonadotropins and Ovarian Development. Edinburgh, E and S Livingstone pp. 312–324
Pedersen T, Peters H, 1968. Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil 17:555–557
Pedersen T, Peters H, 1971. Follicle growth and cell dynamics in the mouse ovary during pregnancy. Fertil Steril 22:42–52
Peters H, 1969. The development of the mouse ovary from birth to maturity Acta Endocrinol 62:98–116
Peters H, 1978. Folliculogenesis in mammals. In: Jones RE (eds.), The Vertebrate Ovary. NY Plenum Press, pp.121–140
Presi J, Pospisil J, Figarova V, Krabec Z, 1974. Stage-dependent changes in binding of iodinated FSH during ovarian follicle maturation in rats Endocrinol Exp 8:291–298
Rahamim E, Eshkol A, Lunenfeld B, 1976. Histochemical demonstration of delta5–3betal-hydroxysteroid dehydrogenase activity in ovaries of intact infant mice and mice treated with anti-gonadotropin. Fertil Steril 27:328–34.
Rao MC, Midgley AR, Richards JS, 1978. Hormonal regulation of ovarian cellular proliferation. Cell 14:71–78
Research in Reproduction, 1986. More studies on biosynthesis by granulosa cells Research in Reproduction 18: 2.
Richards JS, 1974. Estradiol binding to rat corpora lutea during pregnancy. Endocrinology 95:1046–1053
Richards JS, 1975. Estradiol receptor content in rat granulosa cells during follicular development: modification by estradiol and gonadotropins. Endocrinology 97:1174–1184
Richards JS, Midgley AR Jr, 1976. Protein hormone action: a key to understanding ovarian follicular and luteal cell development. Biol of Reprod 14:82–94
Richards JS, Kersey KA, 1980. Changes in theca and granulosa cell function in antral follicles developing during pregnancy in the rat: gonadotropin receptors, cyclic AMP, and estradiol-17B. Biol Reprod 21:1185–1201
Roy SK, Greenwald GS, 1985. An enzymatic method for dissociation of intact follicles from the hamster ovary: histological and quantitative aspects. Biol Reprod 32:203–215
Roy SK, Greenwald GS, 1987. In vitro steroidogenesis by primary to antral follicles in the hamster during the periovulatory period: effects of FSH, LH, and prolactin, Biol Reprod (in Press).
Sachs L, 1986. Growth, differentiation and the reversal of malignancy Sci Am 254:40–47
Sander HJ, Van Leeuwen ECM, de Jong FH, 1984. Inhibin-like activity in media from cultured rat granulosa cells collected throughout the oestrous cycle. J Endocrin 103:77–84
Sanders MM, Midgley AR, 1982. Rat granulosa cell differentiation: an in vitro model. Endocrinology 111:614–624
Selby P, Buick RN, Tannock I, 1983. A critical appraisal of the “human tumor stem-cell assay”. NEJM 308:129–134
Skinner MK, Dorrington JH, 1984. Control of fibronectin synthesis by rat granulosa cells in culture. Endocrinology 115:2029–2031
Smith SS, Ojeda SR, 1986. Neonatal release of gonadotropins is essential for development of ovarian follicle-stimulating hormone (FSH) receptors. Biol Reprod 219–227
Sugawara S, Umezu M, Takeuchi S, 1969. Effect of a single dose of human chorionic gonadotrophin on the ovulatory response of the immature rat J Reprod Fertil 20:333–335
Talbert GB, Meyer RK, McShan WH, 1951. Effect of hypophysectomy at the beginning of proestrus on maturing follicles in the ovary of the rat. Endocrinology 49:687–694
Uilenbroek Jth J, Van der Linden R, 1983. Changes in gonadotrophin binding to rat ovaries during sexual maturation Acta Endocrinol 103:413–419
Upadhyay S, Luciani JM, Zamboni L, 1979. The role of the mesonephros in the development of indifferent gonads and ovaries of the mouse. Ann Biol Anim Biochim Biophys 19:1179–1196
Upahdyay S, Zamboni L, 1982. Ectopic germ cells: natural model for the study of germ cell sexual differentiation. PNAS 79:6584–6586
Van de Wiel DFM, Erkens J, Koops W, Vos E, Van Landeghem AAJ, 1981. Periestrous and midluteal time courses of circulating LH, FSH, prolactin, estradiol-17B and progesterone in the domestic pig. Biol Reprod 24:223–233
Van der Schoot P, DeGreef WJ, 1976. Dioestrous progesterone and pro-oestrous LH in 4- and 5-day cycles of female rats. J Endocrinol 70: 61–68
Wang C, Leung A, 1983. Gonadotropins regulate plasminogen activator production by rat granulosa cells Endocrinology 112:1201–1207
Wright NA, Appleton DR, 1980. The metaphase arrest technique: a critical review. Cell Tissue Kinet 13:643–663
Yanagishita M, Hascall VC, 1984. Metabolism of proteoglycans in rat ovarian granulosa cell culture. J Biol Chem 259 16:10260–10269
Ying SY, Greep RO, 1971. Responsiveness of follicles to gonadotropins during the estrous cycle of the rat. Endocrinology 89:294–297
Zajicek G, 1977. The intestinal proliferon J. Theor. Biol. 67:515–521
Zajicek G, 1979. Proliferon: the functional unit of rapidly proliferating organs. Med Hypotheses 5:161–174
Zajicek G, Michaeli Y, Regev J, 1979. On the progenitor cell migration velocity. Cell Tiss Kinet 12:453–460
Zamboni L, 1974. Fine morphology of the follicle wall and follicle cell-oocyte association. Biol Reprod 10:125–149
Zamboni L, Bezard L, Mauleon P, 1979. The role of mesonephros in the development of the sheep fetal ovary. Ann Biol Anim Biochim Biophys 19:1153–1178
Zeleznik AJ, Midgley AJ, Reichert LE, 1974. Granulosa cell maturation in the rat: increasing binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivo. Endocrinology 95:818–825
Zlotkin T, Farkash Y, Orly J, 1986. Cell specific expression of immuno-reactive cholesterol side chain cleavage cytochrome P-450 during follicular development in the rat ovary. Endocrinology 119:2809–2820
Zoller LC, Weisz J, 1978. Structure and acid phosphatase activity in granulosa cells of preovulatory follicles in rat ovary. Anat Rec 190:592
Zoller LC, Weisz J, 1979. A quantitative cytochemical study of glucose-6-phosphate dehydrogenase and 3B-hydroxysteroid dehydrogenase activity in the membrana granulosa of the ovulable type of follicle of the rat. Histochemistry 62:125–135
Zor U, Strulovici B, Braw R, Lindner HR, Tsafriri, A, 1983. Follicle stimulating hormone-indueed prostaglandin E formation in isolated rat ovarian theca. J Endocrinol 97:43–49
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Hirshfield, A.N., Schmidt, W.A. (1987). Kinetic Aspects of Follicular Development in the Rat. In: Mahesh, V.B., Dhindsa, D.S., Anderson, E., Kalra, S.P. (eds) Regulation of Ovarian and Testicular Function. Advances in Experimental Medicine and Biology, vol 219. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5395-9_11
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