Abstract
Dietary derangement as an agent of teratogenesis has special significance in the history of teratology. The production of congenital anomalies by deficiences of vitamin A and riboflavin marked the beginning of the experimental stage of this science. Since then, these and other nutritional manipulations have served as valuable tools in the development of models, as well as providing information of intrinsic interest in relation to both basic and clinical questions.
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References
Aksu, O., Mackler, B., Shepard, T. H., and Lemire, R. J., 1968, Studies of the development of congenital anomalies in embryos of riboflavin-deficient, galactoflavin-fed rats. II. Role of the terminal electron transport system, Teratology 1: 93.
Allan, J. D., and Brown, J. K., 1968, Maternal phenylketonuria and foetal brain damage, an attempt at prevention by dietary control, in: Some Recent Advances in Inborn Errors of Metabolism ( K. Holt and V. Coffey, eds.), pp. 14–39, E. and S. Livingstone Ltd., Edinburgh.
Allen, L. H., and Zeman, F. J., 1971, Influence of increased postnatal food intake on body composition of progeny of protein-deficient rats, J. Nutr. 101: 1311.
Allen, L. H., and Zeman, F. J., 1973a, Influence of increased postnatal nutrient intake on kidney cellular development in progeny of protein-deficient rats, J. Nutr. 103: 929.
Allen, L. H., and Zeman, F. J., 19736, Kidney function in the progeny of protein-deficient rats, J. Nutr. 103: 1467.
Ailing, C., Bruce, A., Karlsson, I., Sapia, O., and Svennerholm, L., 1972, Effect of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21-day-old rats, J. Nutr. 102: 773.
Alt, H. L., 1938, Iron deficiency in pregnant rats, its effect on the young, Am. J. Dis. Child. 56: 975.
Andersen, D. H., 1949, Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat. Failure to produce cystic fibrosis of the pancreas by maternal vitamin A deficiency, Am. I. Pathol. 25: 163.
Antonov, A. N., 1947, Children born during the seige of Leningrad in 1942,J Pediatr. 30: 250.
Asling, C. W., 1961, Congenital defects of face and palate in rats following maternal deficiency of pteroylglutamic acid, in: Congenital Anomalies of the Face and Associated Structures ( S. Pruzansky, ed.), pp. 173–187, Charles C Thomas, Springfield, Illinois.
Asling, C. W., and Hurley, L. S., 1963, The influence of trace elements on the skeleton. Clin. Orthopaed. 27: 213.
Asling, C. W., Nelson, M. M., Wright, H. V., and Evans, H. M., 1955, Congenital skeletal abnormalities in fetal rats resulting from maternal pteroylglumatic acid deficiency during gestation, Anat. Rec. 121: 775.
Asling, C. W., Hurley, L. S., and Wooten, E., 1960a, Abnormal development of the otic labyrinth in young rats following maternal dietary manganese deficiency, Anat. Rec. 136: 157.
Asling, C. W., Nelson, M. M., Dougherty, H. D., Wright, H. V., and Evans, H. M., 1960b, The development of cleft palate resulting from maternal pteroylglutamic (folic) acid deficiency during the latter half of gestation in rats, Surg. Gynecol. Obstet. 111: 19.
Baird, C. D. C., Nelson, M. M., Monie, I. W., and Evans, H. M., 1954, Congenital cardiovascular anomalies induced by pteroylglumatic acid deficiency during gestation in the rat, Circ. Res. 2: 544.
Bannon, S. L., Higginbottom, R. M., McConnell, J. M., and Kaan, H. W., 1945, Development of galactose cataract in the albino rat embryo, Arch. Ophthalmol. 33: 224.
Barnes, R. H., 1971, Nutrition and man’s intellect and behavior, Fed. Proc. 30: 1429.
Bawden, J. W., and Osborne, J. W., 1962, Tracer study on the effect of dietary calcium deficiency during pregnancy in rats, J Dent. Res. 41: 1349.
Bell, L. T., and Hurley, L. S., 1973, Ultrastructural effects of manganese deficiency in liver, heart, kidney and pancreas of mice. Lab. Invest. 29: 723.
Bell, L. T., Branstrator, M., Roux, C., and Hurley, L. S., 1976, Chromosomal abnormalities in maternal and fetal tissues of magnesium or zinc deficient rats, Teratology 12: 221.
Bennetts, H. W., 1932, Enzootic ataxia of lambs in Western Australia, Aust. Vet. J. 8: 137.
Bennetts, H. W., and Chapman, F. E., 1937, Copper deficiency in sheep in Western Australia: A preliminary account of the aetiology of enzootic ataxia of lambs and an anaemia of ewes, Aust. Vet. J. 13: 138.
Bennetts, H. W., and Beck, A. B., 1942, Enzootic ataxia and copper deficiency of sheep in Western Australia, Australian Council Sci. Ind. Res., Bull. No. 147.
Berg, B. N., 1965, Dietary restriction and reproduction in the rat, J. Nutr. 87: 344.
Berg, B. N., Sigg, E. B., and Greengard, P., 1967, Maintenance of pregnancy in protein-deficient rats by adrenocortical steroid or ACTH administration, Endocrinology 80: 829.
Bergner, L., and Susser, M. W., 1970, Low birth weight and prenatal nutrition: An interpretative review, Pediatrics 46: 946.
Bernhardt, I. B., and Dorsey, D. J., 1974, Hypervitaminosis A and congenital renal anomalies in a human infant, Obstet. Gynecol. 43: 750.
Bessman, S. P., 1972, Genetic failure of fetal amino acid `justification“: A common basis for many forms of metabolic, nutritional, and ”nonspecific“ mental retardation, J. Pediatr. 81: 834.
Blackwell, B. N., Blackwell, R. Q., Yu, T. T. S., Weng, Y. S., and Chow, B. F., 1969, Further studies on growth and feed utilization in progeny of underfed mother rats, J. Nutr. 97: 79.
Bodansky, M., and Duff, V. B., 1941, Relation of parathyroid function and diet to the mineral composition of the bones in rats at the conclusion of pregnancy, J. Nutr. 21: 235.
Boelter, M. D. D., and Greenberg, D. M., 1943, Effect of severe calcium deficiency on pregnancy and lactation in the rat, J. Nutr. 26: 105.
Bologna, U., and Piccioni, V., 1956, Effetti dell’ipovitaminosi B2 sulla gravidanza e sui nati del ratto albino, Soc. Ital. Biol. Speriment. 26: 219.
Brasel, J. A., and Winick, M., 1972, Maternal nutrition and prenatal growth. Experimental studies of effects of maternal undernutrition on fetal and placental growth, Arch. Dis. Child. 47: 479.
Braun, K., Bromberg, Y. M., and Brzezinski, A., 1945, Riboflavin deficiency in pregnancy, J. Obstet. Gynecol. 52: 43.
Brimblecombe, F. S. W., Ashford, J. R., and Fryer, J. G., 1968, Significance of low birth weight in perinatal mortality, Br. J. Prey. Soc. Med. 22: 27.
Brown, M. L., and Snodgrass, C. H., 1965, Effect of dietary level of thiamine on reproduction in the rat, J. Nutr. 85: 102.
Brzezinski, A., Bromberg, Y. M., and Braun, K., 1947, Riboflavin deficiency in pregnancy, its relationship to the course of pregnancy and to the condition of the foetus, J. Obstet. Gynecol. 54: 182.
Burch, R. E., and Sullivan, J. F., 1976, Clinical and nutritional aspects of zinc deficiency and excess, in: Symposium on Trace Elements, (R. E. Burch and J. F. Sullivan, eds.) Med. Clin. N. Amer. 60: 675–685.
Burke, B. S., and Stuart, H. C., 1948, Nutritional requirements during pregnancy and lactation, J. Am. Med. Assoc. 137: 119.
Burke, B. S., Beal, V. A., Kirkwood, S. B., and Stuart, H. C., 1943, The influence of nutrition during pregnancy upon the condition of the infant at birth, J. Nutr. 26: 569.
Burr, G. O., and Burr, M. M., 1930, On the nature and role of the fatty acids essential in nutrition, J. Biol. Chem. 86: 587.
Butcher, R. E., Brunner, R. L., Roth, T., and Kimmel, C. A., 1972, A learning impairment associated with maternal hypervitaminosis-A in rats, Life Sci. I 11 (3): 141.
Cancilla, P. A., and Barlow, R. M., 1966a, Structural changes of the central nervous system in swayback (enzootic ataxia) of lambs. II. Electron microscopy of the lower motor neuron, Acta Neuropathol. 6: 251.
Cancilla, P. A., and Barlow, R. M., 1966b, Structural changes of central nervous system in swayback (enzootic ataxia) of lambs. III. Electron microscopy of the cerebral lesion, Acta Neuropathol. 6: 260.
Carswell, F., Kerr, M. M., and Hutchison, J. H., 1970, Congenital goitre and hypothyroidism produced by maternal ingestion of iodides, Lancet 1: 1241.
Chamberlain, J. G., 1966, Development of cleft palate induced by 6-aminonicotinamide late in rat gestation, Anat. Rec. 156: 31.
Chamberlain, J. G., and Nelson, M. M., 1963a, Congenital abnormalities in the rat resulting from single injections of 6-aminonicotinamide during pregnancy, J. Exp. Zool. 153: 285.
Chamberlain, J. G., and Nelson, M. M., 1963b, Multiple congenital abnormalities in the rat resulting from acute maternal niacin deficiency during pregnancy, Proc. Soc. Exp. Biol. Med. 112: 836.
Chase, H. P., 1973, The effects of intrauterine and postnatal undernutrition on normal brain development, Ann. N.Y. Acad. Sci. 205: 231.
Cheng, D. W., Chang, L. F., and Bairnson, T. A., 1957, Gross observations on developing abnormal embryos induced by maternal vitamin E deficiency, Anat. Rec. 129: 167.
Cheng, D. W., Bairnson, T. A., Rao, A. N., and Subbammal, S., 1960, Effect of variations of rations on the incidence of teratogeny in vitamin E deficient rats, J. Nutr. 71: 54.
Cheng, D. W:, Braun, K. G., Braun, B. J., and Udani, K. H., 1961, Tocopherol content of maternal and fetal rat tissues as related to vitamin E intake during gestation, J. Nutr. 74: 111.
Chepenik, K. P., Johnson, E. M., and Kaplan, S., 1970, Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on levels of adenosine phosphates in developing rat embryos. Teratology 3: 229.
Chow, B. F., 1964, Growth of rats from normal dams restricted in diet in previous pregnancies, J. Nutr. 83: 289.
Chow, B. F., and Lee, C. J., 1964, Effect of dietary restriction of pregnant rats on body weight gain of the offspring, J. Nutr. 82: 10.
Christian, J. R., and Diamond, E. F., 1961, Galactosemia, a family study, Am. J. Dis. Child. 101: 75.
Clark, G. M., Zamenhof, S., van Marthens, E., Grauel, L., and Kruger, L., 1973, The effect of prenatal malnutrition on dimensions of cerebral cortex, Brain Res. 54: 397.
Clausen, J., 1969, The effect of vitamin A deficiency on myelination in the central nervous system of the rat, Eur. J. Biochem. 7: 575.
Clements, F. W., 1960, Health significance of endemic goitre and related conditions. in: Endemic Goitre, pp. 245–260, World Health Organization, Geneva.
Cohlan, S. Q., 1953, Excessive intake of vitamin A as a cause of congenital anomalies in the rat, Science 117: 535.
Cohlan, S. Q., and Stone, S. M., 1961, Effects of dietary and intraperitoneal excess of L-lysine and L-leucine on rat pregnancy and offspring,J Nutr. 74: 93.
Cohlan, S. Q., Jansen, V., Dancis, J., and Piomelli, S., 1970, Microcytic anemia with erythroblastosis in the offspring of magnesium deprived rats. Blood 36: 500.
Comar, C. L., 1956, Radiocalcium studies in pregnancy, Ann. N.Y. Acad. Sci. 64: 281.
Committee on Maternal Nutrition/Food and Nutrition Board, National Research Council, 1970, Maternal Nutrition and the Course of Pregnancy, National Academy of Sciences, Washington, D.C.
Cox, W. M., Jr., and Imboden, M., 1936, The role of calcium and phosphorus in determining reproductive success, J. Nutr. 11: 147.
Dakshinamurti, K., and Stephens, M. C., 1969, Pyridoxine deficiency in the neonatal rat, J. Neurochem. 16: 1515.
Dancis, J., and Springer, D., 1970, Fetal homeostatsis in maternal malnutrition: Potassium and sodium deficiency in rats, Pediatr. Res. 4: 345.
Dancis, J., Springer, D., and Cohlan, S. Q., 1971, Fetal homeostasis in maternal malnutrition. II. Magnesium deprivation. Pediatr. Res. 5: 131.
Daniels, A. L., and Everson, G. J., 1935, The relation of manganese to congenital debility. J. Nutr. 9: 191.
Danks, D. M., Campbell, P. E., Stevens, B. F., Mayne, V., and cartwright, E., 1972, Menkes’s kinky hair syndrome. An inherited defect in copper absorption with widespread effects. Pediatrics 50: 188.
Davis, S. D., Nelson, T., and Shepard, T. H., 1970, Teratogenicity of vitamin BB deficiency: Omphalocele, skeletal and neural defects, and splenic hypoplasia, Science 169: 1329.
DeLuca, H. F., 1974, Vitamin D: The vitamin and the hormone, Fed. Proc. 33: 2211.
Deuel, H. J., Jr., Martin, C. R., and Alfin-Slater, R. B., 1954, The effect of fat level of the diet on general nutrition. XII. The requirement of essential fatty acids for pregnancy and lactation, J. Nutr. 54: 193.
Diamond, I., and Hurley, L. S., 1970, Histopathology of zinc-deficient fetal rats. J. Nutr. 100: 325.
Dickerson, J. W. T., and Hughes, P. C. R. 1972, Growth of the rat skeleton after severe nutritional intrauterine and post-natal retardation. Resuscitation 1: 163.
Dingle, J. T., and Lucy, J. A., 1965, Vitamin A. carotenoids and cell formation, Biol. Rev. 40: (3): 422.
DiSaia, P. J., 1966, Pregnancy and delivery of a patient with a Starr—Edwards mitral valve prosthesis, Obstet. Gynecol. 28: 469.
Dobbing, J., 1972, Vulnerable periods of brain development. In: Lipids, Malnutrition and the Developing Brain ( A. Von Murait, ed.), p. 9, Assoc. Sci. Pub., Amsterdam.
Dreosti, I. E., Tao, S., and Hurley, L. S., 1968, Plasma zinc and leukocyte changes in weanling and pregnant rats during zinc deficiency. Proc. Soc. Exp. Biol. Med. 127: 169.
Dreosti, I. E., Grey, P. C., and Wilkens, D. J., 1972, Deoxyribonucleic acid synthesis, protein synthesis and teratogenesis in zinc-deficient rats. S. Afr. Med. J. 46: 1585.
Dutt, B., and Mills, C. F., 1960, Reproductive failure in rats due to copper deficiency, J. Comp. Pathol. 70: 120.
Eberle, E. D., and Eiduson, S., 1968, Effect of pyridoxine deficiency on aromatic r-amino acid decarboxylase in the developing rat liver and brain, J. Neurochem. 15: 1071.
Emanuel, I., and Sever, L. E., 1973, Questions concerning the possible association of potatoes and neural-tube defects, and an alternative hypothesis relating to maternal growth and development. Teratology 8: 325.
Ensminger, M. E., Bowland, J. P., and Cunha, T. J., 1947, Observations on the thiamine, riboflavin, and choline needs of sows for reproduction]. Anim. Sci. 6: 409.
Ershoff, B. H., and Kruger, L., 1962, A neurological defect in the offspring of rats fed a pantothenic acid-deficient diet during pregnancy. Exp. Med. Surg. 20: 180.
Erway, L. C., and Mitchell, S. E., 1973, Prevention of otolith defect in pastel mink by manganese supplementation. J. Hered. 64: 110.
Erway, L., Hurley, L. S., and Fraser, A., 1966, Neurological defect: Manganese in phenocopy and prevention of a genetic abnormality of inner ear. Science 152: 1766.
Erway, L., Hurley, L. S., and Fraser, A., 1970, Congenital ataxia and otolith defects due to manganese deficiency in mice. J. Nutr. 100: 643.
Erway, L., Fraser, A., and Hurley, L. S., 1971, Prevention of congenital otolith defect in Pallid mutant mice by manganese supplementation. Genetics 67: 97.
Evans, H. M., and Bishop, K. S., 1922, On the existence of a hitherto unrecognized dietary factor essential for reproduction, Science 56: 650.
Evans, H. M., Lepkovsky, S., and Murphy, E. A., 1934a, Vital need of the body for certain unsaturated fatty acids. IV. Reproduction and lactation upon fat-free diet, J. Biol. Chem. 106: 431.
Evans, H. M., Lepkovsky, S., and Murphy, E. A., 1934b, Vital need of the body for certain unsaturated fatty acids. V. Reproduction and lactation upon diets containing saturated fatty acids as their sole source of energy, J Biol. Chem. 106: 441.
Everson, G., Northrop, L., Chung, N. Y., Getty, R., and Pudelkewicz, C., 1954, Effect of varying the intake of calcium pantothenate of rats during pregnancy. I. Chemical findings in the young at birth, J. Nutr. 53: 341.
Everson, G. J., Hurley, L. S., and Geiger, J. F., 1959, Manganese deficiency in the guinea pig. J. Nutr. 68: 49.
Everson, G. J., Tsai, H.-C. C., and Wang, T., 1967, Copper deficiency in the guinea pig, J. Nutr. 93: 533.
Everson, G. J., Shrader, R. E., and Wang, T., 1968, Chemical and morphological changes in the brains of copper-deficient guinea pigs,J Nutr. 96: 115.
Fairney, A., and Weir, A. A., 1970, The effect of abnormal maternal plasma calcium levels on the offspring of rats, J. Endocrinol. 48: 337.
Falchuk, K. H., Fawcett, D. W., and Vallee, B. L., 1975, Role of zinc in cell division of Euglena Gracilis, J. Cell Sci. 17: 57.
Felig, P., and Lynch, V., 1970, Starvation in human pregnancy: Hypoglycemia, hypoinsulinemia, and hyperketonemia, Science 170: 990.
Fell, B. F., Williams, R. B., and Mills, C. F., 1961, Further studies of nervous-tissue degeneration resulting from “conditioned” copper deficiency in lambs. Proc. Nutr. Soc. 20:xxvii.
Fell, B. F., Mills, C. F., and Boyne, R., 1965, Cytochrome oxidase deficiency in the motor neurones of copper-deficient lambs: A histochemical study, Res. Vet. Sci. 6: 170.
Fellers, F. X., and Schwartz, R., 1958, Etiology of the severe form of idiopathic hypercalcemia of infancy, N. Engl. J. Med. 259: 1050.
Ferm, V. H., 1972, The teratogenic effects of metals on mammalian embryos, Adv. Teratol. 5: 51.
Ferm, V. H., 1967, Potentiation of the teratogenic effect of vitamin A with exposure to low environmental temperature, Life Sci. 6: 493.
Fierro-Benitez, R., Ramirez, I., Garces, J., Jaramillo, C., Moncayo, F., and Stanbury, J. B., 1974, The clinical pattern of cretinism as seen in highland Ecuador, Am. J. Clin. Nutr. 27: 531.
Fillmore, S. J., and McDevitt, E., 1970, Effects of coumarin compounds on the fetus, Ann. Intern. Med. 73: 731.
Finnerty, J. J., and Mackay, B. R., 1962, Antepartum thrombophlebitis and pulmonary embolism, Obstet. Gynecol. 19: 405.
Fisch, R. O., Doeden, D., Lansky, L. L., and Anderson, J. A., 1969, Maternal phenylketonuria, Am. J. Dis. Child. 118: 847.
Forfar, J. O., Tompsett, S. L., and Forshall, W., 1959, Biochemical studies in idiopathic hypercalcaemia of infancy, Arch. Dis. Child. 34: 525.
Fraser, J. L., and Watt, H. J., 1964, Megaloblastic anemia in pregnancy and the puerperium, Am. J. Obstet. Gynecol. 89: 532.
Fratta, I. D., 1969, Nicotinamide deficiency and thalidomide: Potential teratogenic disturbances in Long—Evans rats, Lab. Anim. Care 19: 727.
Fratta, I., Zak, S. B., Greengard, P., and Sigg, E. B., 1964, Fetal death from nicotinamide- deficient diet and its prevention by chlorpromazine and imipramine, Science 145: 1429.
Friedman, W. F., and Mills, L. F., 1969, The relationship between vitamin D and the craniofacial and dental anomalies of the supravalvular aortic stenosis syndrome, Pediatrics 43: 12.
Friedman, W. F., and Roberts, W. C., 1966, Vitamin D and the supravalvular aortic stenosis syndrome, the transplacental effects of vitamin D on the aorta of the rabbit, Circulation 34: 77.
Gal, I., Sharman, I. M., and Pryse-Davies, J., 1972, Vitamin A in relation to human congenital malformations. Adv. Teratol. 5: 143.
Giroud, A., and Boisselot, J., 1947, Répercussions de l’avitaminose B2 sur l’embryon du rat, Arch. Fr. Pediatr. 4: 319.
Giroud, A. and Lefè6vres-Boisselot, J., 1951, Anomalies provoquées chez le foetus en l’absence d’acide folique, Arch. Fr. Pediatr. 8: 648.
Giroud, A., and Martinet, M., 1954, Fentes du palais chez l’embryon de rat par hypervitaminose A. C.R. Soc. Biol. 148: 1742.
Giroud, A., and Martinet, M., 1955a, Hypervitaminose A et anomalies chez le foetus de rat, Rev. Intern. Vitaminol. 26: 10.
Giroud, A., and Martinet, M., 1955b, Production d’un excès de liquide amniotique dan l’anencéphalie, C.R. Soc. Biol. 149: 452.
Giroud, A., and Martinet, M., 1955c, Malformations diverses du foetus de rat suivant les stades d’administration de vitamine A en excès, C.R. Soc. Biol. 149: 1088.
Giroud, A., and Martinet, M., 1956a, Tératogenèse par hautes doses de vitamine A en fonction des stades du développement, Arch. Anat. Microsc. Morphol. Exp. 45: 7.
Giroud, A., and Martinet, M., 1956b, Malformations de la face et hypervitaminose A, Rev. Stomatol. 57: 454.
Giroud, A., and Martinet, M., 1956e, Hypervitaminose A et malformations congénitales, Ann. Pediatr. (Semaine des Hopitaux) 32: 1.
Giroud, A., and Martinet, M., 1956d, Hypovitaminose et hypervitaminose A chez le jeune et chez l’embryon, Etud. Néo-Natales 5: 55.
Giroud, A., and Martinet, M., 1959a, Tératogénèse par hypervitaminose A chez lè rat, la souris, le cobaye et le lapin, Arch. Fr. Pediatr. 16: 1.
Giroud, A., and Martinet, M., 1959b, Anencéphalie chez la souris par hypervitaminose A, C.R. Assoc. Anat., XLVI Réunion, Montpellier, March 22–26, p. 288.
Giroud, A., and Martinet, M., 1959c, Malformations oculaires avec fibrose du vitré chez des embryons de lapin soumis à l’hypervitaminose A, Bull. Soc. Ophtalmol. 1959 (3): 1.
Giroud, A., and Martinet, M., 1962, Légèreté de la dose tératogène de la vitamine A, C.R. Soc. Biol. 156: 449.
Giroud, A., Lévy, G., Lefè6vres, J., and Dupuis, R., 1952, Chute du taux de la riboflavine au stade ou se déterminent les malformations embryonnaires, Intern. Z. Vitamin’ 23: 490.
Giroud, A., Lévy, G., and Lefèbvres, J., 1954, Recherches sur le taux de l’acide pantothénique chez les mères et les foetus normaux et chez les mères carencées, Rev. Intern. Vitaminol. 25: 148.
Giroud, A., Lefèbvres, J., Prost, H., and Dupuis, R., 1955, Malformations des membres dues à des lésions vasculaires chez le foetus de rat déficient en acide pantothénique, J. Embryol. Exp. Morphol. 3: 1.
Giroud, A., ‘Lefèbvres, J., and Dupuis, R., 1956, Action partiellement compensatrice de doses élevées d’acide ascorbique au cours de la gestation, chez des rattes déficientes en acide pantothénique, C.R. Soc. Biol. 150: 1735.
Giroud, A., Delmas, A., Prost, H., and Lefèbvres, J., 1957, Malformations encéphaliques par carence en acide pantothénique et leur interprétation, Acta Anat.. 29: 17.
Giroud, A., Martinet, M., and Roux, C., 1958a, Anencéphalie, encéphalocèles, ménigocèles par hypervitaminose A, Arch. Fr. Pediatr. 15: (6): 1.
Giroud, A., Martinet, M., and Roux, C., 1958b, Urétéro-hydronéphrose expérimentale chez l’embryon par hypervitaminose A, Arch. Fr. Pediatr. 15: (4): 1.
Giroud, A., Martinet, M., and Solère, M., 1958c, Encéphalocèles, méningocèles par hypervitaminose A et considérations cliniques, Rev. Neurol. 98: 13.
Giroud, A., Delmas, A., and Martinet, M., 1959, Etude morphogénétique sur des embryons anencéphales, Arch. Anat. Histol. Embryol. Norm. Exper. 42: 203.
Giroud, A., Boisselot-Lefèbvres, J., and Dupuis, R., 1961, Carence tératogène en acide pantothénique. Légèreté de la carence, Bull. Soc. Chim. Biol. 43: 859.
Goodenday, L. S., and Gordan, G. S., 1971, No risk from vitamin D in pregnancy, Ann. Intern. Med. 75: 807.
Gortner, R. A., Jr., and Ekwurtzel, J. B., 1965, Incidence of teratogeny induced by vitamin E deficiency in the rat, Proc. Soc. Exp. Biol. Med. 119: 1069.
Grainger, R. B., O’Dell, B. L., and Hogan, A. G., 1954, Congenital malformations as related to deficiencies of riboflavin and vitamin B12, source of protein, calcium to phosphorus ratio and skeletal phosphorus metabolism, J. Nutr. 54: 33.
Green, H. G., Gareis, F. J., Shepard, T. H., and Kelley, V. C., 1971, Cretinism associated with maternal sodium iodide I131 therapy during pregnancy, Am. J. Dis. Child. 122: 247.
Greengard, P., Sigg, E. B., Fratta, I., and Zak, S. B., 1966, Prevention and remission by adrenocortical steroids of nicotinamide deficiency disorders and of 6-aminonicotinamide toxicity in rats and dogs, J. Pharmacol. Exp. Ther. 154: 624.
Hale, F., 1933, Pigs born without eye balls, J. Hered. 24: 105.
Hale, F., 1934, The relation of vitamin A to the eye development in the pig, Record of Proceedings, Annual Meeting, 1934, American Society of Animal Production, p. 126.
Hale, F., 1935, The relation of vitamin A to anophthalmos in pigs, Am. J. Ophthalmol. 18: 1087.
Hale, F., 1937, The relation of maternal vitamin A deficiency to microphthalmia in pigs, Tex. State J. Med. 33: 37.
Hall, G. A., and Howell, J. McC., 1969, The effect of copper deficiency on reproduction in the female rat, Br. J. Nutr. 23: 41.
Hall, M. H., 1972, Folic acid deficiency and congenital malformation, J. Obstet. Gynaecol. Br. 79: 159.
Hall, S. M., and Zeman, F. J., 1968, Kidney function of the progeny of rats fed a low protein diet. J. Nutr. 95: 49.
Hart, E. B., and Steenbock, H., 1918, Thyroid hyperplasia and the relation of iodine to the hairless pig malady, J. Biol. Chem. 33: 313.
Hart, E. B., McCollum, E. V., Steenbock, H., and Humphrey, G. C., 1911, Physiological effect on growth and reproduction of rations balanced from restricted sources, Wis. Exp. Stn. Res. Bull. 17: 160.
Hart, E. B., Steenbock, H., Humphrey, G. C., and Hulce, R. S., 1924, New observations and a reinterpretation of old observations on the nutritive value of the wheat plant, J. Biol. Chem. 62: 315.
Haworth, J. C., Ford, J. D., and Younoszai, M. K., 1969, Effect of galactose toxicity on growth of the rat fetus and brain, Pediatr. Res. 3: 441.
Hibbard, B. M., 1964, The role of folic acid in pregnancy, J. Obstet. Gynecol. 71: 529.
Hibbard, B. M., and Hibbard, E. D., 1966, Recurrence of defective folate metabolism in successive pregnancies, J. Obstet. Gynaecol. 73: 428.
Hibbard, E. D., and Smithells, R. W., 1965, Folic acid metabolism and human embryopathy, Lancet 1: 1254.
Hirsh, J., Cade, J. F., and O’Sullivan, E. F., 1970, Clinical experience with anticoagulant therapy during pregnancy, Br. Med. J. 1: 270.
Hogan, A. G., O’Dell, B. L., and Whitley, J. R., 1950, Maternal nutrition and hydrocephalus in newborn rats, Proc. Soc. Exp. Biol. Med. 74: 272.
Hsueh, A. M., Blackwell, R. Q., and Chow, B. F., 1970, Effect of maternal diet in rats on feed consumption of the offspring, J. Nutr. 100: 1157.
Hurley, L. S., 1968a, Approaches to the study of nutrition in mammalian development, Fed. Proc. 27: 193.
Hurley, L. S., 1968b, The consequences of fetal impoverishment, Nutr. Today 3: 3.
Hurley, L. S., 1969, Nutrients and genes: Interactions in development. Nutr. Rev. 27: 3.
Hurley, L. S., 1971, Magnesium deficiency during pregnancy and its effect on the offspring. A comprehensive review. Proceedings of First International Symposium on Magnesium Deficiency in Human Pathology, pp. 481–492, May, Vittel, France, Imprimerie Amelot, 27 Brionne, France.
Hurley, L. S., 1974a, Aspects of mineral metabolism in the perinatal period. in: Perinatal Pharmacology: Problems and Priorities, U. Dancis and J. C. Hwang, eds.), pp. 149–158, Raven Press, New York.
Hurley, L. S., 1974b, Zinc deficiency, potatoes, and congenital malformations in man, Teratology 10: 205.
Hurley, L. S., and Asling, C. W., 1963, Localized epiphyseal dysplasia in offspring of manganese-deficient rats, Anat. Rec. 145: 25.
Hurley, L. S., and Bell, L. T., 1974a, Amelioration by copper supplementation of mutant gene crinkled in mice, Teratology 9: A22.
Hurley, L. S., and Bell, L. T., 1974b, Genetic influence on response to dietary manganese deficiency, J. Nutr. 104: 133.
Hurley, L. S., and Cosens, G., 1970, Teratogenic magnesium deficiency in pregnant rats, Teratology 3: 202.
Hurley, L. S., and Cosens, G., 1971, Congenital malformations and fetal anemia resulting from magnesium deficiency in rats, Fed. Proc. 30: 516.
Hurley, L. S., and Cosens, G., 1974, Reproduction and prenatal development in relation to dietary zinc level, in: Trace Element Metabolism in Animals, Vol. 2 ( W. G. Hoekstra, J. W. Suttie H. E. Ganther, and W. Mertz, eds.), pp. 516–518, University Park Press, Baltimore.
Hurley, L. S., and Everson, G. J., 1959, Delayed development of righting reflexes in offspring of manganese-deficient rats, Proc. Soc. Exp. Biol. Med. 102: 360.
Hurley, L. S., and Everson, G. J., 1963, Influence of timing of short-term supplementation during gestation on congenital abnormalities of manganese deficient rats, J. Nutr. 79: 23.
Hurley, L. S., and Mutch, P. B., 1973, Prenatal and postnatal development after transitory gestational zinc deficiency in rats. J. Nutr. 103: 649.
Hurley, L. S., and Shrader, R. E., 1972, Congenital malformations of the nervous system in zinc-deficient rats, in: Neurobiology of the Trace Metals Zinc and Copper, (C. C. Pfeiffer, ed.), pp. 7–51, International Review of Neurobiology, Suppl. 1, Academic Press, New York.
Hurley, L. S. and Shrader, R. E., 1975, Abnormal development in preimplantation eggs after four days of maternal dietary zinc deficiency, Nature 254: 427.
Hurley, L. S., and Swenerton, H., 1966, Congenital malformation resulting from zinc deficiency in rats. Proc. Soc. Exp. Biol. Med. 123: 692.
Hurley, L. S., and Swenerton, H., 1971, Lack of mobilization of bone and liver zinc under teratogenic conditions of zinc deficiency in rats. J. Nutr. 101: 597.
Hurley, L. S., and Tao, S., 1972, Alleviation of teratogenic effects of zinc deficiency by simultaneous lack of calcium. Am. J. Physiol. 222: 322.
Hurley, L. S., and Volkert, N. E., 1965, Pantothenic acid and coenzyme A in the developing guinea pig liver, Biochim. Biophys. Acta. 104: 372.
Hurley, L. S., Everson, G. J., and Geiger, J. F., 1958, Manganese deficiency in rats: Congenital nature of ataxia, J. Nutr. 66: 309.
Hurley, L. S., Wooten, E., Everson, G. J., and Asling, C. W., 1960, Anomalous development of ossification in the inner ear of offspring of manganese deficient rats, J. Nutr. 71: 15.
Hurley, L. S., Wooten, E., and Everson, G. J., 1961a, Disproportionate growth in offspring of manganese-deficient rats. II. Skull, brain, and cerebrospinal fluid pressure, J. Nutr. 74: 282.
Hurley, L. S., Everson, G. J., Wooten, E., and Asling, C. W., 1961b, Disproportionate growth in offspring of manganese-deficient rats. I. The long bones, J. Nutr. 74: 274.
Hurley, L. S., Volkert, N. E., and Eichner, J. T., 1965, Pantothenic acid deficiency in pregnant and non-pregnant guinea pigs, with special reference to effects on the fetus, J. Nutr. 86: 201.
Hurley, L. S., Gowan, J., and Shrader, R., 1968a, Genetic–nutritional interaction in relation to manganese and calcification. in: Les tissues calcfiés, Symposium européen, Société d’enseignement supérieur, Paris, pp. 101–104.
Hurley, L. S., Dreosti, I. E., and Swenerton, H., 1968b, Studies on zinc enzymes and nucleic acid synthesis in relation to congenital malformations in zinc deficient rats, Proc. West. Hemisphere Nutr. Congr. II, San Juan, Puerto Rico, p. 39.
Hurley, L. S., Gowan, J., and Swenerton, H., 1971, Teratogenic effects of short-term and transitory zinc deficiency in rats, Teratology 4: 199.
Hurley, L. S., Sucher, K., Story, D., and Cosens, G., 1973, Interaction of dietary protein and zinc in the pregnant rat, J. Nutr. 103:xxv.
Hutchings, D. E., and Gaston, J., 1974, The effects of vitamin A excess administered during the mid-fetal period on learning and development in rat offspring, Deli. Psychobiol. 7: 225.
Hutchings, D. E., Gibbon, J., and Kaufman, M. A., 1973, Maternal vitamin A excess during the early fetal period: Effects on learning and development in the offspring, Dev. Psychobiol. 6: 445.
Hytten, F. E., and Leitch, I., 1971, The Physiology of Human Pregnancy, Blackwell Scientific Publications, Oxford, U.K.
Innes, J. R. M., 1936, “Swayback”—a demyelinating disease of lambs with affinities to Schilder’s encephalitis in man, Vet. Rec. 48: 1539.
Innes, J. R. M., and Shearer, G. D., 1940, “Swayback”; a demyelinating disease of lambs with affinities to Schilder’s encephalitis in man]. Comp. Pathol. Ther. 53:1.
Isselbacher, K. J., 1959, Galactose metabolism and galatosemia, Am. J. Med. 26: 715.
Itoh, H., Hansard, S. L., Glenn, J. C., Hoskins, F. H., and Thrasher, D. M., 1967, Placental transfer of calcium in pregnant sows on normal and limited-calcium rations, J. Anim. Sci. 26: 335.
Jaffe, N. R., and Johnson, E. M., 1973, Alterations in the ontogeny and specific activity of phosphomonoesterases associated with abnormal chondrogenesis and osteogenesis in the limbs of fetuses from folic acid-deficient pregnant rats, Teratology 8: 33.
Jeans, P. C., Smith, M. B., and Stearns, G., 1944, Incidence of prematurity in relation to maternal nutrition, J. Am. Dent. Assoc. 31: 576.
Johnson, E. M., and Chepenik, K. P., 1966, Effects of folic acid deficiency on enzymatic differentiation in embryonic tissues and organs. Anat. Rec. 154: 362.
Kalter, H., and Warkany, J., 1957, Congenital malformations in inbred strains of mice induced by riboflavin-deficient, galactoflavin-containing diets, J. Exp. Zool. 136: 531.
Kelly, F. C., and Snedden, W. W., 1960, Prevalence and geographical distribution of endemic goitre, in: Endemic Goitre, pp. 27–233, World Health Organization, Geneva.
Kenney, M. A., and Roderuck, C. E., 1963, Fatal syndrome associated with vitamin E status of pregnant rats, Proc. Soc. Exp. Biol. Med. 114: 257.
Kerber, I. J., Warr, O. S., III, and Richardson, C., 1968, Pregnancy in a patient with a prosthetic mitral valve, J. Am. Med. Assoc. 203: 223.
Kerr, G. R., Chamove, A. S., Harlow, H.-F., and Waisman, H. A., 1968, “Fetal PKU”: The effect of maternal hyperphenylalaninemia during pregnancy in the Rhesus monkey (Macaca mulatta), Pediatrics 42:27.
Kinney, C. S., and Morse, L. M., 1964, Effect of a folic acid antagonist, aminopterin, on fetal development and nucleic acid metabolism in the rat, J. Nutr. 84: 288.
Kirksey, A., and Pike, R. L., 1962, Some effects of high and low sodium intakes during pregnancy in the rat. 1. Food consumption, weight gain, reproductive performance, electrolyte balances, plasma total protein and protein fractions in normal pregnancy, J Nutr. 77: 33.
Kirksey, A., Pike, R. L., and Callahan, J. A., 1962, Some effects of high and low sodium intakes during pregnancy in the rat. II. Electrolyte concentrations of maternal plasma, muscle, bone and brain and of placenta, amniotic fluid, fetal plasma and total fetus in normal pregnancy, J. Nutr. 77: 43.
Kitay, D. Z., 1969, Folic acid deficiency in pregnancy, Am. J. Obstet. Gynecol. 104: 1067.
Kochhar, D. M., 1967, Teratogenic activity of retinoic acid, Acta Pathol. Microbiol. Scand. 70: 398.
Kochhar, D. M., 1968, Studies of vitamin A-induced teratogenesis: Effects on embryonic mesenchyme and epithelium, and on incorporation of H3-thymidine, Teratology 1: 299.
Kochhar, D. M., 1973, Limb development in mouse embryos, I. Analysis of teratogenic effects of retinoic acid, Teratolgy 7: 289.
Kochhar, D. M., and Johnson, E. M., 1965, Morphological and autoradiographic studies of cleft palate induced in rat embryos by maternal hypervitaminosis A, J. Embryol. Exp. Morphol. 14: 223.
Körner, W. F., and Nowak, H., 1971, The influence of vitamin B6 deficiency during pregnancy on the fetal postnatal development of the rat, in: Malformations congénitales des Mammifères ( H. Tuchmann-Duplessis, ed.), pp. 243–253, Masson et Cie, Paris.
Kratzing, C. C., and Perry, J. J., 1971, Hypertension in young rats following choline deficiency in maternal diets, J. Nutr. 101: 1657.
Kraus, A. P., Perlow, S., and Singer, K., 1949, Danger of Dicurmarol treatment in pregnancy, J. Am. Med. Assoc. 139: 758.
Lamming, G. E., Salisbury, G. W., Hays, R. L., and Kendall, K. A., 1954a, The effect of incipient vitamin A deficiency on reproduction in the rabbit. I. Decidua, ova and fertilization, J. Nutr. 52: 217.
Lamming, G. E., Woollam, D. H. M., and Millen, J. W., 1954b, Hydrocephalus in young rabbits associated with maternal vitamin A deficiency, Br. J. Nutr. 8: 363.
Langer, P., 1960, History of goitre, in: Endemic Goitre, pp. 9–25, World Health Organization, Geneva.
Langman, J., and Welch, G. W., 1966, Effect of vitamin A on development of the central nervous system, J. Comp. Neurol. 128: 1.
Languran, J., and Welch, G. W., 1967, Excess vitamin A and development of the cerebral cortex, J. Comp. Neurol. 131: 15.
Latham, M. C., and Cobos, F., 1971, The effects of malnutrition on intellectual development and learning, Am. J. Public Health 61: 1307.
Lee, Y. C. P., King, J. T., and Visscher, M. B., 1953, Strain difference in vitamin E and B12 and certain mineral trace-element requirements for reproduction in A and Z mice, Am. J. Physiol. 173: 456.
Lefèbvres-Boisselot, J., 1951, Role tératogène de la déficience en acide pantothénique chez le rat, Ann. Med. 52: 225.
Lefebvres-Boisselot, J., and Dupuis, R., 1956, Réduction de la croissance pondérale et trouble du métabolisme de l’eau, chez les foetus de rates déficientes en acide pantothénique, J. Physiol. 48: 598.
Loh, K. R. W., Shrader, R. E., and Zeman, F. J., 1971, Effect of maternal protein deprivation on neonatal intestinal absorption in rats, J. Nutr. 101: 1663.
Luse, S. A., Rhys, A., and Lessey, R., 1970, Effects of maternal phenylketonuria on the rat fetus, Am. J. Obstet. Gynecol. 108: 387.
Lyon, M. F., 1953, Absence of otoliths in the mouse: An effect of the pallid mutant, J. Genet. 51: 638.
Macomber, D., 1927, Effect of a diet low in calcium on fertility, pregnancy and lactation in the rat, J. Am. Med. Assoc. 88: 6.
Marin-Padulla, M., and Ferm, V. H., 1965, Somite necrosis and developmental malformations induced by vitamin A in the golden hamster, J. Embryol. Exp. Morphol. 13 (1): 1.
Martin, M. P., Bridgforth, E., McGanity, W. J., and Darby, W. J., 1957, The Vanderbilt cooperative study of maternal and infant nutrition. X. Ascorbic acid, J. Nutr. 62: 201.
Masi, P. L., Frumento, F., and Parrini, C., 1966, Malformazioni congenite maxillo-dentali nella prole di topi trattati con ipervitaminosi A, Riv. Ist. Sieroter. Ital. 21: 1129.
Maxwell, J. P., 1934, Osteomalacia and diet, Nutr. Abstr. Rev. 4: 1.
McClure, T. J., 1961, Pathogenesis of early embryonic mortality caused by fasting pregnant rats and mice for short periods, J. Reprod. Fertil. 2: 381.
McLaren, D. S., 1968, To eat to see, Nutr. Today 3: 2.
Meader, R. D., 1965, Livers of choline-deficient pregnant and fetal rats. Anat. Rec. 153: 407.
Mellanby, M., and Coumoulos, H., 1944, The improved dentition of 5-year-old London schoolchildren, a comparison between 1943 and 1929, Br. Med. J. 1: 837.
Millen, J. W., and Woollam, D. H. M., 1956, The effect of the duration of vitamin A deficiency in female rabbits upon the incidence of hydrocephalus in their young, J. Neurol. Psychiatr. 19: 17.
Millen, J. W., Woollam, D. H. M., and Lamming, G. E., 1953, Hydrocephalus associated with deficiency of vitamin A, Lancet 2: 1234.
Millen, J. W., Woollam, D. H. M., and Lamming, G. E., 1954, Congenital hydrocephalus due to experimental hypovitaminosis A, Lancet 2: 679.
Miller, J. R., 1962, Strain difference in response to the teratogenic effect of maternal fasting in the house mouse, Can. J. Genet. Cytol. 4: 69.
Miller, Z., Poncet, I., and Takacs, E., 1962, Biochemical studies on experimental congenital malformations: flavin nucleotides and folic acid in fetuses and livers from normal and riboflavin-deficient rats, J. Biol. Chem. 237: 968.
Mills, C. F., and Fell, B. F., 1960, Demyelination in lambs born of ewes maintained on high intakes of sulphate and molybdate, Nature 185: 20.
Mills, C. F., Quarterman, J., Chesters, J. K., Williams, R. B., and Dalgarno, A. C., 1969, Metabolic role of zinc, Am. J. Clin. Nutr. 22: 1240.
Mirone, L., 1954, Effect of choline-deficient diets on growth, reproduction and mortality of mice. Am. J. Physiol. 179: 49.
Mjolnerod, O. K., Dommerud, S. A., Rasmussen, K., and Gjeruldsen, S. T., 1971, Congenital connective-tissue defect probably due to D-penicillamine treatment in pregnancy, Lancet 1: 673.
Monie, I. W., Nelson, M. M., and Evans, H. M., 1954, Abnormalities of the urinary system of rat embryos resulting from maternal pteroylglutamic acid deficiency, Anat. Rec. 120: 119.
Monie, I. W., Nelson, M. M., and Evans, H. M., 1957a, Persistent right umbilical vein as a result of vitamin deficiency during gestation, Circ. Res. 5: 187.
Monie, I. W., Nelson, M. M., and Evans, H. M., 1957b, Abnormalities of the urinary system of rat embryos resulting from transitory deficiency of pteroylglutamic acid during gestation, Anat. Rec. 127: 711.
Moon, W.-H. Y., and Kirksey, A., 1973, Cellular growth during prenatal and early postnatal periods in progeny of pyridoxine-deficient rats,J Nutr. 103: 123.
Moore, R. A., Bittenger, I., Miller, M. L., and Hellman, L. M., 1942, Abortion in rabbits fed a vitamin K deficient diet, Am. J. Obstet. Gynecol. 43: 1007.
Morriss, G. M., 1972, Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A, J. Anat. 113: 241.
Mouriquand, G., and Edel, V., 1953, Sur l’hypervitaminose C, C.R. Soc. Biol. 147: 1432.
Mouriquand, G., Gillet, R., and Coeur, A., 1935, La phase “d’avortement” et la phase de protection maternelle et foetale dans le scorbut experimental, C.R. Soc. Biol. 119: 1230.
Naeye, R. L., 1965, Cardiovascular abnormalities in infants malnourished before birth, Biol. Neonate 8: 104.
Naeye, R. L., Diener, M. M., and Dellinger, W. S., 1969, Urban poverty: Effects on prenatal nutrition, Science 166: 1026.
Naeye, R. L., Diener, M. M., Harcke, H. T., Jr., and Blanc, W. A., 1971, Relation of poverty and race to birth weight and organ and cell structure in the newborn, Pediatr. Res. 5: 17.
Nanda, R., 1971, Tritiated thymidine labelling of the palatal processes of rat embryos with cleft palate induced by hypervitaminosis A. Arch. Oral Biol. 16: 435.
Nanda, R., 1974, Effect of vitamin A on the potentiality of rat palatal processes to fuse in vivo and in vitro, Cleft Palate J. 11: 123.
Nelson, M. M., and Evans, H. M., 1946, Pantothenic acid deficiency and reproduction in the rat, J. Nutr. 31: 497.
Nelson, M. M., and Evans, H. M., 1948, Effect of desoxypyridoxine on reproduction in the rat, Proc. Soc. Exp. Biol. Med. 68: 274.
Nelson, M. M., and Evans, H. M., 1949, Pteroylglutamic acid and reproduction in the rat, J. Nutr. 38: 11.
Nelson, M. M., and Evans, H. M., 1953, Relation of dietary protein levels to reproduction in the rat, J. Nutr. 51: 71.
Nelson, M. M., and Evans, H. M., 1954, Maintenance of pregnancy in the absence of dietary protein with estrone and progesterone, Endocrinology 55: 543.
Nelson, M. M., and Evans, H. M., 1955a, Relation of thiamine to reproduction in the rat, J. Nutr. 55: 151.
Nelson, M. M., and Evans, H. M., 1955b, Maintenance of pregnancy in absence of dietary protein with progesterone, Proc. Soc. Exp. Biol. Med. 88: 444.
Nelson, M. M., Lyons, W. R., and Evans, H. M., 1951, Maintenance of pregnancy in pyridoxine-deficient rats when injected with estrone and progesterone, Endocrinology 48: 726.
Nelson, M. M., Asling, C. W., and Evans, H. M., 1952, Próduction of multiple congenital abnormalities in young by maternal pteroylglutamic acid deficiency during gestation, J. Nutr. 48: 61.
Nelson, M. M., Lyons, W. R., and Evans, H. M., 1953, Comparison of ovarian and pituitary hormones for maintenance of pregnancy in pyridoxine-deficient rats, Endocrinology 52: 585.
Nelson, M. M., Wright, H. V., Asling, C. W., and Evans, H. M., 1955, Multiple congenital abnormalities resulting from transitory deficiency of pteroylglutamic acid during gestation in the rat, J. Nutr. 56: 349.
Nelson, M. M., Wright, H. V., Baird, C. D. C., and Evans, H. M., 1956a, Effect of 36-hour period of pteroylglutamic acid deficiency on fetal development in the rat, Proc. Soc. Exp. Biol. Med. 92: 554.
Nelson, M. M., Baird, C. D. C., Wright, H. V., and Evans, H. M., 1956b, Multiple congenital abnormalities in the rat resulting from riboflavin deficiency induced by the antimetabolite galactoflavin, J. Nutr. 58: 125.
Nelson, M. M., Wright, H. V., Baird, C. D. C., and Evans, H. M., 1957, Teratogenic effects of pantothenic acid deficiency in the rat, J. Nutr. 62: 395.
Netzloff, M., Johnson, E., and Kaplan, S., 1968, Respiratory changes observed in abnormally developing rat embryos, Teratology 1: 375.
Neuweiler, W., 1951, Die Hypervitaminose und ihre Beziehung zur Schwangerschaft, Intern Z. Vitaminforsch 22: 392.
Newberne, P. M., and O’Dell, B. L., 1961, Vitamin B12 deficiency and hydrocephalus, in: Disorders of the Developing Nervous System ( W. S. Fields and M. M. Desmond, eds.), pp. 123–143, Charles C Thomas, Springfield, Illinois.
Newberne, P. M., and Young, V.R., 1973, Marginal vitamin B12 intake during gestation in the rat has long term effects on the offspring, Nature 242: 263.
Newberne, P. M., Ahlstrom, A., and Rogers, A. E., 1970, Effects of maternal dietary lipotropes on prenatal and neonatal rats, J. Nutr. 100: 1089.
Niiyama, Y., Kishi, K., and Inoue, G., 1970, Effect of ovarian steroids on maintenance of pregnancy in rats fed diets devoid of one essential amino acid, J. Nutr. 100: 1461.
Niiyama, Y., Kishi, K., Endo, S., and Inoue, G., 1973, Effect of diets devoid of one essential amino acid on pregnancy in rats maintained by ovarian steroids, J. Nutr. 103: 207.
Nishikawa, M., 1963, Influence of maternal fasting for a short period upon the development of mouse embryos, Kaibogaku Zasshi 38: 181.
Nishimura, H., and Miyamoto, S., 1969, Teratogenic effects of sodium chloride in mice, Acta Anat. 74: 121.
O’Dell, B. L., 1968, Trace elements in embryonic development, in Symposium on Nutrition and Prenatal Development, Fed. Proc. 27: 199.
O’Dell, B. L., Hardwick, B. C., and Reynolds, G., 1961, Mineral deficiencies of milk and congenital malformation in the rat, J. Nutr. 73: 151.
Olwin, J. H., and Koppel, J. L., 1969. Anticoagulant therapy during pregnancy, Obstet. Gynecol. 34: 847.
Orent, E. R., and McCollum, E. V., 1931, Effects of deprivation of manganese in the rat, J. Biol. Chem. 92: 651.
Orent-Keiles, E., Robinson, A., and McCollum, E. V., 1937, The effects of sodium deprivation on the animal organism, Am. J. Physiol. 119: 651.
Ornoy, A., Menczel, J., and Nebel, L., 1968, Alterations in the mineral composition and metabolism of rat fetuses and their placentas induced by maternal hypervitaminosis D2, Isr. J. Med. Sci. 4: 827.
Ornoy, A., Nebel, L., and Menczel, Y., 1969, Impaired osteogenesis of fetal long bones induced by maternal hypervitaminosis D2, Arch. Pathol. 87: 563.
Orony, A., Kaspi, T., and Nebel, L., 1972, Persistent defects of bone formation in young rats following maternal hypervitaminosis D2, Arch. J. Med. Sci. 7: 943.
Palacios-Macedo, X., Diaz-Devis, C., and Escudero, J., 1969, Fetal risk with the use of coumarin anticoagulant agents in pregnant patients with intracardiac ball valve prosthesis, Am. J. Cardiol. 24: 853.
Palludan, B., 1966a, A-Avitaminosis in Swine, Munksgaard, Copenhagen.
Palludan, B., 1966b, Swine in teratological studies, in: Swine in Biomedical Research ( L. K. Bustad and R. O. McClella, eds.), pp. 51–78, Frayn Printing, Seattle, Washington.
Palsson, P. A., and Grimsson, H., 1953, Demyelination in lambs from ewes which feed on sea-weeds, Proc. Soc. Exp. Biol. Med. 83: 518.
Pang, R. L., and Kirksey, A., 1974, Early postnatal changes in brain composition in progeny of rats fed different levels of dietary pyridoxine, J. Nutr. 104: 111.
Parmelee, A. H., Allen, E., Stein, I. F., and Buxbaum, H., 1940, Three cases of congenital goiter, Am. J. Obstet. Gynecol. 40: 145.
Persaud, T. V. N., and Tiesj, D., 1969, Developmental abnormalities in rat induced by amino acid leucine, Naturwissenschaften 56: 37.
Persaud, T. V. N., and Kaplan, S., 1970, The effects of hypoglycin-A, a leucine analogue, on the development of rat and chick embryos, Life Sci. (II) 9: 1305.
Pharoah, P.O.D., Buttfield, I. H., and Hetzel, B. S., 1971, Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy, Lancet 1: 308.
Phillips, G. D., and Sundaram, S. K., 1966, Sodium depletion of pregnant ewes and its effects on foetuses and foetal fluids, J. Physiol. 184: 889.
Pike, R. L., 1951, Congenital cataract in albino rats fed different amounts of tryptophan and niacin, J. Nutr. 44: 191.
Plumlee, M. P., Thrasher, D. M., Beeson, W. M., Andrews, F. N., and Parker, H. E., 1956, The effects of a manganese deficiency upon the growth, development, and reproduction of swine, J. Anim. Sci. 15: 352.
Pond, W. G., Wagner, W. C., Dunn, J. A., and Walker, E. F., Jr., 1968, Reproduction and early postnatal growth of progeny in swine fed a protein-free diet during gestation, J. Nutr. 94: 309.
Popjak, G., 1946, Maternal and foetal tissue-and plasma-lipids in normal and cholesterol-fed rabbits, J. Physiol. 105: 236.
Potier de Courcy, G., 1966a, Caractères globaux des métabolismes nucléique et protéolique chez le foetus de rat carencé en acide pantothénique, Arch. Sci. Physiol. 20: 43.
Potier de Courcy, G., 1966b, Conséquences de la carènce folique sur les caractères généraux des métabolismes nucléique et protéique chez le foetus de rat, Arch. Sci. Physiol. 20: 189.
Potier de Courcy, G., and Desmettre-Miguet, S., 1970, Effects de la carence en riboflavine sur quelques éléments minéraux des tissus foeto-maternels du rat, Arch. Sci. Physiol. 24: 181.
Potier de Courcy, G., and Terroine, T., 1966, Les désoxyribonucléases I et II dans la vie pré-et post-natale du rat normal et carencé en acide folique, Arch. Sci. Physiol. 20: 1.
Potier de Courcy, G., and Terroine, T., 1968a, Influence de la carence en riboflavine sur la fonction phosphatasique alcaline des organes maternels et foetaux à différents stades de la gestation, Ann. Nutr. Aliment. 22: 95.
Potier de Courcy, G., and Terroine, T., 1968b, Conséquences chez le rat de la carence en riboflavine sur la composition globale de certains tissus maternels et foetaux, Arch. Sci. Physiol. 22: 1.
Potier de Courcy, G., Susbielle, H., and Terroine, T., 1970, Etude du zinc dans l’ariboflavinose tératogéne chez le rat, Arch. Sci. Physiol. 24: 409.
Potvliege, P. R., 1972, Hypervitaminosis D2 in gravid rats, Arch. Pathol. 73: 29.
Primrose, T., and Higgins, A., 1971, A study in human antepartum nutrition, J. Reprod. Med. 7: 257.
Purvis, R. J., MacKay, G. S., Cockburn, F., Barrie, W. J. McK., Wilkinson, E. M., Belton, N. R., and Forfar, J. O., 1973, Enamel hypoplasia of the teeth associated with neonatal tetany: A manifestation of maternal vitamin-D deficiency, Lancet 2: 811.
Quick, A. J., 1946, Experimentally induced changes in the prothrombin level of the blood. III. Prothrombin concentration of new-born pups of a mother given dicumarol before parturition, J Biol. Chem. 164: 371.
Richardson, L. R., and Hogan, A. G., 1946, Diet of mother and hydrocephalus in infant rats, J. Nutr. 32: 459.
Rivers, J. M., Krook, L., and Cormier, A., 1970, Biochemical and histological study of guinea pig fetal and uterine tissue in ascorbic acid deficiency, J. Nutr. 100: 217.
Roberts, H. E., Williams, B. M., and Harvard, A., 1966a, Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. I. Field, clinical gross anatomical and biochemical observations, J. Comp. Pathol. 76: 279.
Roberts, H. E., Williams, B. M., and Harvard, A., 1966b, Cerebral oedema in lambs associated with hypocuprosis, and its relationship to swayback. II. Histopathological findings, J. Comp. Pathol. 76: 285.
Roderick, L. M., 1929, The pathology of sweet clover disease in cattle, J. Am. Vet. Med. Assoc. 75: 314.
Roeder, L. M., and Chow, B. F., 1972, Maternal undernutrition and its long-term effects on the offspring, Am. J. Clin. Nutr. 25: 812.
Rosa, F. W., and Turshen, M., 1970, Fetal Nutrition, Bull. W. H. O. 43: 785.
Rosen, J. F., Roginsky, M., Nathenson, G., and Finberg, L., 1974, 25-hydroxyvitamin D, plasma levels in mothers and their premature infants with neonatal hypocalcemia, Am. J. Dis. Child. 127: 220.
Ross, M. L., and Pike, R. L., 1956, The relationship of vitamin B6 to protein metabolism during pregnancy in the rat,J Nutr. 58: 251.
Rothman, D., 1970, Folic acid in pregnancy, Am. J. Obstet. Gynecol. 108: 149.
Roux, C., and Aubry, M., 1966, Teratogenic effect of an inhibition of cholesterol synthesis (AY9944) in the rat, C.R. Soc. Biol. 160: 1353.
Roux, C., and Dupuis, R., 1961, Urohydronéphroses par carence pantothénique,Arch. Fr. Pediatr. 18: 1337.
Roux, J. F., and Yoshioka, T., 1970, Lipid metabolism in the fetus during development, Clin. Obstet. Gynecol. 13: 595.
Roux, C., Fournier, P., Dupuis, Y., and Dupuis, R., 1962a, Anomalies oculaires congénitales dans la carence en vitamine A, Bull. Soc. Ophthalmol. Fr. 1962: 1.
Roux, C., Fournier, P., Dupuis, Y., and Dupuis, R., 1962b, About teratogenic vitamin A deficiency, Biol. Neonate 4: 371.
Ruffo, A., and Vescia, A., 1941, Importanza dell’acido nicotinico per it ratto, Boll. Soc. Ital. Biol. Sper. 16: 185.
Runner, M. N., and Miller, J. R., 1956, Congenital deformity in the mouse as a consequence of fasting, Anat. Rec. 124: 437.
Russell, K. P., Rose, H., and Starr, P., 1957, The effects of radioactive iodine on maternal and fetal thyroid function during pregnancy, Surg. Gynecol. Obstet. 104: 560.
Samborskaya, E. P., and Ferdman, T. D., 1966, The mechanism of termination of pregnancy by ascorbic acid, Bull. Exp. Biol. Med. 62: 934 (in Russian).
Sarma, V., 1959, Maternal vitamin A deficiency and fetal microcephaly and anophthalmia, Obstet. Gynecol. 13: 299.
Schofield, F. W., 1923–1924, Damaged sweet clover: The cause of a new disease in cattle simulating hemorrhagic septicemia and blackleg, J. Am. Vet. Med. Assoc. 64: 553.
Schumacher, M. F., Williams, M. A., and Lyman, R. L., 1965, Effect of high intakes of thiamine, riboflavin and pyridoxine on reproduction in rats and vitamin requirements of the offspring, J. Nutr. 86: 343.
Scott, K. E., and Usher, R., 1966, Fetal malnutrition: Its incidence, causes, and effects, Am. J. Obstet. Gynecol. 94: 951.
Scott, D. E., Whalley, P. J., and Pritchard, J. A., 1970, Maternal folate deficiency and pregnancy wastage. II. Fetal malformation, Obstet. Gynecol. 36: 26.
Scrimshaw, N. S. and Gordon, E., 1968, Malnutrition, Learning and Behavior, M. I. T. Press, Cambridge, Mass.
Scriver, C. R., 1970, Vitamin D dependency, Pediatrics 45: 361.
Scriver, C. R., 1974, Inborn errors of metabolism: A new frontier of nutrition, Nutr. Today 9: 4.
Segal, S., and Bernstein, H., 1963, Observations on cataract formation in the newborn offspring of rats fed high-galactose diet, J. Pediatr. 62: 363.
Sever, L. E., and Emanuel, I., 1973, Is there a connection between maternal zinc deficiency and congenital malformations of the central nervous system in man? Teratology 7: 117.
Shepard, T. H., and Bass, G. L., 1970, Organ culture of limb buds from riboflavin-deficient and normal rat embryos in normal and riboflavin deficient media, Teratology 3: 163.
Shepard, T. H., Lemire, R. J., Aksu, O., and Mackler, B., 1968, Studies of the development of congenital anomalies in embryos of riboflavin deficient, galactoflavin fed rats. I. Growth and embryologic pathology, Teratology 1: 75.
Shils, M. E., and McCollum, E. V., 1943, Further studies on the symptoms of manganese deficiency in the rat and mouse, J. Nutr. 26: 1.
Shrader, R. E., and Everson, G. J., 1967, Anomalous development of otoliths associated with postural defects in manganese-deficient guinea pigs, J. Nutr. 91: 453.
Shrader, R. E., and Zeman, F. J., 1969, Effect of maternal protein deprivation on morphological and enzymatic development of neonatal rat tissue, J. Nutr. 99: 401.
Shrader, R. E., and Zeman, F. J., 1973a, Skeletal development in rats as affected by maternal protein deprivation and postnatal food supply, J. Nutr. 103: 792.
Shrader, R. E., and Zeman, F. J., 1973b, In vitro synthesis of anterior pituitary growth hormone as affected by maternal protein deprivation and postnatal food supply, J. Nutr. 103:1012.
Shrader, R. E., Erway, L., and Hurley, L. S., 1973, Mucopolysaccharide synthesis in the developing inner ear of manganese-deficient and pallid mutant mice, Teratology 8: 257.
Sima, A., and Sourander, P., 1973, The effect of perinatal undernutrition on perineurial diffusion barrier to exogenous protein, Acta Neuropathol. (Berlin) 24: 263.
Sisson, T. R. C., and Lund, C. J., 1958, The influence of maternal iron deficiency on the newborn, Am. J. Clin. Nutr. 6: 376.
Smith, C. A., 1947a, Effects of maternal undernutrition upon the newborn infant in Holland (1944–1945), J. Pediatr. 30: 229.
Smith, C. A., 19476, The effect of wartime starvation in Holland upon pregnancy and its product, Am. J. Obstet. Gynecol. 53: 599.
Smith, C. A., Oberhelman, H. A., Jr., Storer, E. H., Woodward, E. R., and Dragstedt, L. R., 1951, Production of experimental cretinism in dogs by the administration of radioactive iodine, Arch. Surg. 63: 807.
Solursh, M., and Meier, S., 1973, ‘The selective inhibition of mucopolysaccharide synthesis by vitamin A treatment of cultured chick embryo chondrocytes, Calcif. Tissue Res. 13: 131.
Sontag, L. W., Munson, P., and Huff, E., 1936, Effects on the fetus of hypervitaminosis D and calcium and phosphorus deficiency during pregnancy, Am. J. Dis. Child. 51: 304.
Stanbury, J. B., and Querido, A., 1956, Genetic and environmental factors in cretinism: A classification, J. Clin. Endocrinol. Metab. 16: 1522.
Stanbury, J. B., and Querido, A., 1957, On the nature of endemic cretinism, J. Clin. Endocrinol. Metab. 17: 801.
Stein, Z., Susser, M., Saenger, G., and Marolla, F., 1972, Nutrition and mental performance, Science 178: 708.
Stone, M. L., 1968, Effects on the fetus of folic acid deficiency in pregnancy, Clin. Obstet. Gynecol. 11: 1143.
Suomalainen, P., 1950, Effect of E-avitaminosis on the histiotrophic nutrition of the mouse embryo, Nature 165: 364.
Suttle, N. F., and Field, A. C., 1968, Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. II. Copper status of the newborn lamb, J. Comp. Pathol. 78: 363.
Swanson, W. W., and lob, V., 1939, The growth of fetus and infant as related to mineral intake during pregnancy, Am. J. Obstet. Gynecol. 38: 382.
Swenerton, H., and Hurley, L. S., 1968, Severe zinc deficiency in male and female rats,J Nutr. 95: 8.
Swenerton, H., Shrader, R., and Hurley, L. S., 1969, Zinc-deficient embryos: Reduced thymidine incorporation, Science 166: 1014.
Swenerton, H., Shrader, R., and Hurley, L. S., 1972. Lactic and malic dehydrogenases in testes of zinc-deficient rats, Proc. Soc. Exp. Biol. Med. 141: 283.
Takekoshi, S., 1964, The mechanism of vitamin A induced teratogenesis, J. Embryol. Exp. Morphol. 12: 263.
Tao, S. H., and Hurley, L. S., 1975, Effect of dietary calcium deficiency during pregnancy on zinc mobilization in intact and parathyroidectomized rats, J. Nutr. 105: 220.
Terada, M., 1970, Effect of intermittent fasting before pregnancy upon maternal fasting as a teratogen in mice, J. Nutr. 100: 767.
Toverud, K. U., and Toverud, G., 1931, Studies on the mineral metabolism during pregnancy and lactation and its bearing on the disposition to rickets and dental caries, Acta Paediatr. Suppl. 2 12: 1.
Tuchmann-Duplessis, H., and Mercier-Parot, L., 1964, Avortements et malformations sous l’effet d’un agent provoquant une hyperlipémie et une hypercholestérolémie, Bull. Acad. Natl. Med. (Paris) 148: 392.
Tuchmann-Duplessis, H., Lefébvres-Boisselot, J., and Mercier-Parot, L., 1959, L’action tératogène de l’acide x-methyl-folique sur diverses espéces animales, Arch. Fr. Pediatr. 15 (4): 1.
Tuncer, M., 1970, Bone development, incidence of hypoglycemia and effect of maternal and fetal factors in low birth weight infants, Turk. J. Pediatr. 12: 59.
Turbow, M. M., and Chamberlain, J. G., 1968, Direct effects of 6-aminonicotinamide on the developing rat embryo in vitro and in in vivo, Teratology 1: 103.
Ullrey, D. E., Becker, D. E., Terrill, S. W., and Notzold, R. A., 1955, Dietary levels of pantothenic acid and reproductive performance of female swine, J. Nutr. 57: 401.
van den Berg, B. J., and Yerushalmy, J., 1966, The relationship of the rate of intrauterine growth of infants of low birth weight to mortality, morbidity, and congenital anomalies, J. Pediatr. 69: 531.
van Gelder, D. W., and Darby, F. U., 1944, Congenital and infantile beriberi, J. Pediatr. 25: 226.
Wallis, G. C., 1938, Some effects of vitamin D deficiency on mature dairy cows, J. Dairy Sci. 21: 315.
Warkany, J., 1943, Effect of maternal rachitogenic diet on skeletal development of young rat, Am. J. Dis. Child. 66: 511.
Warkany, J., and Deuschle, F. M., 1955, Congenital malformations induced in rats by maternal riboflavin deficiency: Dentofacial changes, J. Am. Dent. Assoc. 51: 139.
Warkany, J., and Petering, H. G., 1972, Congenital malformations of the central nervous system in rats produced by maternal zinc deficiency,Teratology 5: 319.
Warkany, J., and Petering, H. G., 1973, Congenital malformations of the brain produced by short zinc deficiencies in rats, Am. J. Ment. Defic. 77: 645.
Warkany, J., and Roth, C. B., 1948, Congenital malformations induced in rats by maternal vitamin A deficiency. II. Effect of varying the preparatory diet upon the yield of abnormal young, J. Nutr. 35: 1.
Warkany, J., and Schraffenberger, E., 1943, Congenital malformations induced in rats by maternal nutritional deficiency. V. Effects of purified diet lacking riboflavin, Proc. Soc. Exp. Biol. Med. 54: 92.
Warkany, J., and Schraffenberger, E., 1944, Congenital malformations of the eyes induced in rats by maternal vitamin A deficiency, Proc. Soc. Exp. Biol. Med. 57: 49.
Warkany, J., and Schraffenberger, E., 1946, Congenital malformation induced in rats by maternal vitamin A deficiency, Arch. Ophthalmol. 35: 150.
Wilson, J. G., and Warkany, J., 1947, Epithelial keratinization as evidence of fetal vitamin A deficiency, Proc. Soc. Exp. Biol. Med. 64: 419.
Wilson, J. G., and Warkany, J., 1948, Malformations in the genito-urinary tract induced by maternal vitamin A deficiency in the rat, Am. J. Anat. 83: 357.
Wilson, J. G., and Warkany, J., 1950, Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies, Pediatrics 5: 708.
Wilson, J. G., Roth, C. B., and Warkany, J., 1953, An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation, Am. J. Anat. 92: 189.
Wilson, M. G., Meyers, H. I., and Peters, A. H., 1967, Postnatal bone growth of infants with fetal growth retardation, Pediatrics 40: 213.
Winick, M., 1969, Malnutrition and brain development, J. Pediatr. 74: 667.
Winick, M., and Noble, A., 1966, Cellular response in rats during malnutrition at various ages, J. Nutr. 89: 300.
Winick, M., Brasel, J. A., and Velasco, E. G., 1973, Effects of prenatal nutrition upon pregnancy risk, Clin. Obstet. Gynecol. 16: 184.
Woodard, J. C., and Newberne, P. M., 1967, The pathogenesis of hydrocephalus in newborn rats deficient in vitamin 1312, J. Embryol. Exp. Morphol. 17: 177.
Wooley, D. W., and van der Hoven, T., 1964, Serotonin deficiency in infancy as one cause of a mental defect in phenylketonuria, Science 144: 883.
Yasuda, M., Nanjo, H., and Suzuki, M., 1966, The effect of fasting upon the development of embryos in elderly pregnant mice, Kaibogaku Zasshi 41: 43.
Zamenhof, S., and van Marthens, E., 1974, Study of factors influencing prenatal brain development, Mol. Cell. Biochem. 4: 157.
Zamenhof, S., Hall, S. M., Grauel, L., van Marthens, E., and Donahue, M. J., 1974, Deprivation of amino acids and prenatal brain development in rats, J. Nutr. 104: 1002.
Zeman, F. J., 1967, Effect on the young rat of maternal protein restriction, J. Nutr. 93: 167.
Zeman, F. J., 1968, Effects of maternal protein restriction on the kidney of the newborn young of rats, J. Nutr. 94: 111.
Zeman, F. J., 1970, Effect of protein deficiency during gestation on postnatal cellular development in the young rat,J Nutr. 100: 530.
Zeman, F. J., and Stanbrough, E. C., 1969, Effect of maternal protein deficiency on cellular development in the fetal rat, J. Nutr. 99: 274.
Zeman, F. J., Shrader, R. E., and Allen, L. H., 1973, Persistent effects on maternal protein deficiency in postnatal rats, Nutr. Rep. Int. 7: 421.
Zilversmit, D. B., Remington, M., and Hughes, L. B., 1972, Fetal growth and placental permeability in rabbits fed cholesterol, J. Nutr. 102: 1681.
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Hurley, L.S. (1977). Nutritional Deficiencies and Excesses. In: Wilson, J.G., Fraser, F.C. (eds) General Principles and Etiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2850-6_7
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