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Aspirin-Sensitive Asthma: Its Relationship to Inhibition of Prostaglandin Biosynthesis

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Book cover Prostaglandins and Thromboxanes

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 13))

Abstract

Patients with bronchial asthma do not constitute a homogenous population. One group which can be clearly distinguished on clinical grounds is formed by patients who do not tolerate aspirin. Although such patients have been described soon after introduction of aspirin to pharmacotherapy, it was only recently that aspirin-sensitive asthma has been recognized as a distinct clinical syndrome. In fact the sequence of symptoms and the natural history of this syndrome are so characteristic that, based on large clinical observations, a typical or “classic” case has been constructed (Samter and Beers, 1968).

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References

  • Arroyave, C.M., Stevenson, D.D., Bhat, K.N., and Tan, E.M., 1976, Oral challenge in asthmatic patients: a study of plasma mediators (abstr.). J. Allergy Clin. Immunol. 57: 206.

    Google Scholar 

  • Chafee, F.H., and Settipane, G.A., 1974, Aspirin intolerance. I. Frequency in an allergic population. J. Allergy Clin. Immun. 53: 193–204.

    Article  Google Scholar 

  • Cuthbert, M.F., 1973, Prostaglandins and respiratory smooth muscle, in: Prostaglandins: Pharmacological and Therapeutic Advances, (M.F. Cuthbert and D.B. Lippincott, eds.), pp. 252–265, Philadelphia.

    Google Scholar 

  • Fisherman, E.W., and Cohen, G.N., 1974, Alpha-beta-adrenergic imbalance in intrinsic-intolerance rhinitis or asthma. Ann. Allergy 33: 86–101.

    PubMed  CAS  Google Scholar 

  • Gilmore, N., Vane, J.R., and Wyllie, J.H., 1968, Prostaglandins released by the spleen. Nature 218: 1135–1140.

    Article  PubMed  CAS  Google Scholar 

  • Grodzińska, L., Panczenko, B., and Gryglewski, R.J., 1975, Generation of prostaglandin E-like material by the guinea-pig trachea contracted by histamine. J. Pharm. Pharmac. 27: 88–91.

    Article  Google Scholar 

  • Kaliner, M., Wasserman, S.I., and Austen, K.F., 1973, Immunologic release of chemical mediators from human nasal polyps. N. Engl. J. Med., 289: 277–281.

    Article  PubMed  CAS  Google Scholar 

  • Ku, E.C., Wasvary, J.M., and Cash, W.D., 1975, Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase. Biochem. Pharmac. 24: 641–643.

    Article  CAS  Google Scholar 

  • Lichtenstein, L.M., 1973, The control of IgE-mediated histamine release, in: Asthma, (K.F. Austen, and L.M. Lichtenstein, eds.), p. 91. Academic Press, New York-London.

    Google Scholar 

  • McDonald, J.R., Mathison, D.A., and Stevenson, D.D., 1972, Aspirin intolerance in asthma. I. Detection by oral challenge. J. Allergy Clin. Immunol. 50: 198–207.

    Article  PubMed  CAS  Google Scholar 

  • Mathé, A.A., Hedqvist, P., Holmgren, A., and Svanborg, N., 1973, Bronchial hyperreactivity to prostaglandin F2 and histamine in patients with asthma. Br. Med. J. 1: 193–196.

    Article  PubMed  Google Scholar 

  • Maur, K., Adkinson, N.F., Van Metre, T.E., Marsch, D.G., and Norman, P.S., 1974, Aspirin intolerance in a family. J. Allergy Clin. Immun. 54: 380–395.

    Article  Google Scholar 

  • Niżankowska, E., 1976, The effect of prostaglandins on bronchial reactivity in asthma. Doctors thesis, Copernicus Academy of Medicine, Kraków.

    Google Scholar 

  • Samter, M., and Beers, R.J., 1967, Concerning the nature of intolerance to aspirin. J. Allergy 40: 281–293.

    Article  PubMed  CAS  Google Scholar 

  • Samter, M., and Beers, R.J., Jr., 1968, Intolerance to aspirin: clinical studies and consideration to its pathogenesis. Ann. Int. Med. 68: 975–983.

    PubMed  CAS  Google Scholar 

  • Samter, M., 1973, Intolerance to aspirin. Hosp. Pract. (Dec.), 8: 85–90.

    Google Scholar 

  • Schlumberger, H.D., Löbbecke, E.A., and Kallós, P., 1974, Acetylsalicylic acid intolerance. Acta Med. Scand. 196: 451–458.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, H.J., and Bennet, B., 1973, The differential effect of acetylsalicylic acid on in vitro aggregation of platelets from normal asthmatic and aspirin-sensitive subjects. Int. Arch. Allergy, 45: 899–903.

    Article  PubMed  CAS  Google Scholar 

  • Snider, D.E., and Parker, C.W., 1976, Altered arachidonic acid metabolism in platelets from aspirin-sensitive subjects. Clin. Res. 450A.

    Google Scholar 

  • Szczeklik, A., Gryglewski, R.J., and Czerniawska-Mysik, G., 1974, Is aspirin-sensitive asthma due to the inhibition of prostaglandin biosynthesis? 1974, Abstracts of IXth Congress of European Academy of Allergy and Clin. Immunology, London, 34.

    Google Scholar 

  • Szczeklik, A., Gryglewski, R.J., and Czerniawska-Mysik, G., 1975a, Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. Br. Med. J. 1: 67–69.

    Article  CAS  Google Scholar 

  • Szczeklik, A., Musiai, J., and Serwohska, M., 1975b, The effect of aspirin on bleeding time and platelet aggregation in patients hypersensitive to non-steroidal anti-inflammatory drugs. Abstracts of XI Congress of Pol. Soc. Hematol., Gdansk, p.64.

    Google Scholar 

  • Szczeklik, A., Gryglewski, R.J., Czerniawska-Mysik, G., and Zmuda, A., 1976a, Aspirin-induced asthma: hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. J. Allergy Clin. Immunol. 58: 10–18.

    Article  CAS  Google Scholar 

  • Szczeklik, A., and Czerniawska-Mysik, G., 1976b, Prostaglandins and aspirin-induced asthma, Lancet 1: 488.

    Article  Google Scholar 

  • Szczeklik, A., Nizankowska, E., and Niżankowski, R., 1976c, Bronchial reactivity to prostaglandins F2, E2 and histamine in different types of asthma. Respiration-subjected for publication.

    Google Scholar 

  • Szczeklik, A., Gryglewski, R.J., Olszewski, E., Dembińska-Kieć, A., and Czerniawska-Mysik, G., 1976d, Aspirin sensitive asthma: the effect of aspirin on the release of prostaglandins from nasal polyps. New. Eng. J. Med. — subjected for publication.

    Google Scholar 

  • Vane, J.R., 1964, The use of isolated organs for detecting active substances in the circulating blood. Br. D. Pharmac. Chemother. 23: 360–373.

    CAS  Google Scholar 

  • Van Leeuwen, W.S., 1928, Pathognomonische Bedeutung der Uebermpfindlichkeit gegen Aspirin bei Asthmatikeren. Münch. Med. Woch. 75: 1588–1592.

    Google Scholar 

  • Vaneslow, N.A., and Smith, J.R., 1967, Bronchial asthma induced by indomethacin. Ann. Int. Med. 66: 568–572.

    Google Scholar 

  • Walker, J.L., 1973, The regulatory function of prostaglandins in the release of histamine and SRS-A from passively sensitized human lung tissue, in: Advances in Biosciences, Vol. 9, (S. Bergström and S. Bernhard, eds.), p. 235, Pergamon Press, Vieweg-Oxford.

    Google Scholar 

  • Yurchak, A.M., Wicher, K., and Arbesman, C.E., 1970, Immunologic studies on aspirin, J. Allergy 46: 245–252.

    Article  PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Gryglewski, R.J., Szczeklik, A., Niżankowska, E. (1977). Aspirin-Sensitive Asthma: Its Relationship to Inhibition of Prostaglandin Biosynthesis. In: Berti, F., Samuelsson, B., Velo, G.P. (eds) Prostaglandins and Thromboxanes. NATO Advanced Study Institutes Series, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2778-3_13

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  • DOI: https://doi.org/10.1007/978-1-4684-2778-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2780-6

  • Online ISBN: 978-1-4684-2778-3

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