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Mechanisms of Fibre Genotoxicity

  • Chapter
Mechanisms in Fibre Carcinogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 223))

Abstract

Neoplastic transformation is a multistep process involving the arrangement, amplification, mutation or deletion of specific genes. Several mechanisms may account for these gene modifications; they include point mutations and chromosome mutations (see Barrett, this volume). Genotoxic agents may be responsible for primary or secondary events which play a critical role in cell transformation by the production, not only of point mutations, but also of heritable changes through gene modifications and rearrangements. Agents that interact with DNA structure, chromosomes or even interfere with DNA metabolism are potentially genotoxic.

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Authors and Affiliations

  1. Laboratory of Cellular and Molecular Toxicology, CHU Henri Mondor, 94010, Creteil Cedex, France

    Marie-Claude Jaurand

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  1. Marie-Claude Jaurand
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  1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

    Robert C. Brown  & John A. Hoskins  & 

  2. Inhalation Toxicology Research Institute, Albuquerque, New Mexico, USA

    Neil F. Johnson

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© 1991 Plenum Press, New York

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Jaurand, MC. (1991). Mechanisms of Fibre Genotoxicity. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_24

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  • DOI: https://doi.org/10.1007/978-1-4684-1363-2_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1365-6

  • Online ISBN: 978-1-4684-1363-2

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