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Durability of Various Mineral Fibres in Rat Lungs

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Mechanisms in Fibre Carcinogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 223))

Abstract

The durability of crocidolite, glass fibres, and wollastonite in rat lungs was examined after intratracheal instillation. Experiments were based on the assumption that thin (< 2 µm), long (> 5 µm) and durable fibres are of special importance for the carcinogenic potency of these materials. After serial sacrifices up to two years after administration of the test materials, the retained fibres in lungs were analysed by scanning or transmission electron microscopy. Retention half times of between 10 and more than 500 days were calculated for the various fibre types investigated.

The results show that the chemical composition of mineral fibres is an essential determinant of the durability of these materials in lungs. A correlation between the durability of fibres in lungs and results for carcinogenic potency in the intraperitoneal test (i.p.) shows the plausibility of an interrelationship.

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References

  • Bellmann,B., Muhle,H., Pott,F., König,H., Klöppel,H. and Spurny,K. (1987) Persistence of man-made mineral fibres (MMMF) and asbestos in rat lungs. Ann. Occup. Hyg. 31: 693–709.

    Article  PubMed  CAS  Google Scholar 

  • Bellmann,B., Muhle,H. and Pott,F. (1990) Study on the durability of chemically different glass fibres in lungs of rats. Zbl. Hyg. 190: 310–314.

    CAS  Google Scholar 

  • Davis,J.M.G. (1986) A review of experimental evidence for the carcinogenicity of man-made vitreous fibres. Scand. J. Work Environ. Hlth 12:Suppl. 1, 12–17.

    Google Scholar 

  • IARC (1987) Silica and some silicates. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Vol. 42,. World Health Organisation International Agency on Cancer, Lyon.

    Google Scholar 

  • Morgan,A. (1980) Effect of length on the clearance of fibres from the lung and on body formation. In, “Biological effects of mineral fibres”, ed. Wagner,J.C. IARC, Lyon, pp. 329–335.

    Google Scholar 

  • Morgan,A., Holmes,A. (1986) Solubility of asbestos and man-made mineral fibres in vitro and in vivo: its significance in lung disease. Environ. Res. 39: 475–484.

    Article  PubMed  CAS  Google Scholar 

  • Muhle,H., Bellmann,B., Creutzenberg,O., Fuhst,R., Kilpper,R., Koch,W., MacKenzie,J.C., Morrow,P., Mohr,U., Takenaka,S. and Mermelstein,R. (1990) Subchronic inhalation study of toner in rats. Inhal. Toxicol. 2: 341–359.

    Article  Google Scholar 

  • Pott,F., Ziem,U., Reiffer,F.-J., Huth,F., Ernst,H. and Mohr,U. (1987) Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats. Exp. Path. (Jena) 32: 129–152.

    CAS  Google Scholar 

  • Pott,F., Roller,M., Ziem,U., Reiffer,F.J., Bellmann,B., Rosenbruch,M. and Huth,F. (1989) rats. In, “Non-occupational exposure to mineral fibres”, eds. Bignon,J., Peto,J. and Saracci,R. IARC Science Publication No. 90. International Agency for Research on Cancer, Lyon, pp. 173–179.

    Google Scholar 

  • Pott,F., Schlipköter,H.-W., Roller,M., Rippe,R.M., Germann,P.-G., Mohr,U. and Bellmann,B. (1990) Kanzerogenität von Glasfasern mit unterschiedlicher Beständigkeit. Zbl. Hyg. 189: 563–566.

    CAS  Google Scholar 

  • Rittinghausen,S., Ernst,H., Muhle,H., Fuhst,R. and Mohr,U. (1990) Histopathological analysis of tumour types after intraperitoneal injection of mineral fibres in rats. This volume.

    Google Scholar 

  • Vincent,J.H., Johnston,A.Y., Jones,A.D., Bolton,R.E. and Addison, J. (1985) Kinetics of deposition and clearance of inhaled mineral dusts during chronic exposure. Br. J. Indust. Med. 42: 707–715.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Fraunhofer Institute of Toxicology and Aerosol Research, D-3000, Hannover, Germany

    H. Muhle & B. Bellmann

  2. Medical Institute for Environmental Hygiene at the Heinrich Heine University, D-4000, Dusseldorf, Germany

    F. Pott

Authors
  1. H. Muhle
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  2. B. Bellmann
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  3. F. Pott
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Editor information

Editors and Affiliations

  1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

    Robert C. Brown  & John A. Hoskins  & 

  2. Inhalation Toxicology Research Institute, Albuquerque, New Mexico, USA

    Neil F. Johnson

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© 1991 Plenum Press, New York

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Muhle, H., Bellmann, B., Pott, F. (1991). Durability of Various Mineral Fibres in Rat Lungs. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_17

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  • DOI: https://doi.org/10.1007/978-1-4684-1363-2_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1365-6

  • Online ISBN: 978-1-4684-1363-2

  • eBook Packages: Springer Book Archive

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