Abstract
Dramatic changes in the axonal transport of several enzymes involved in transmitter metabolism occur following axotomy (for an extensive review see Grafstein and Forman, 1980). Axonal transport of transmitter-related enzymes has generally been found to be reduced, as is nerve content of these enzymes. Similarly, the amount of enzyme activity present in the perikarya of the cells of origin of the damaged axons is decreased. As we shall see, there are exceptions to each of these statements. These changes are thought to reflect a change in emphasis in the neuronal economy from that of a functioning cell carrying out its essential role in the life of the organism to that of a convalescent invalid. Because the neuron has lost its efferent connections, the enzymes involved in transmitter metabolism are presumed to be, at least temporarily, useless, and the production of some of them in the perikaryon and their export from it are curtailed.
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© 1984 Plenum Press, New York
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McDougal, D.B. (1984). Transport of Transmitter-Related Enzymes. In: Elam, J.S., Cancalon, P. (eds) Axonal Transport in Neuronal Growth and Regeneration. Advances in Neurochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1197-3_7
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DOI: https://doi.org/10.1007/978-1-4684-1197-3_7
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