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Effect of a Conditioning Lesion on Axonal Transport During Regeneration

The Role of Slow Transport

  • Chapter
Axonal Transport in Neuronal Growth and Regeneration

Part of the book series: Advances in Neurochemistry ((ANCH,volume 22))

Abstract

The term “conditioning lesion effect” refers to the earlier formation and/or accelerated outgrowth of axonal sprouts in response to a second growth stimulus as compared to a single growth stimulus. Although the first (conditioning) stimulus can be a direct axotomy or partial denervation of an end organ (to produce collateral sprouting), it is important that the second (testing) stimulus be a direct axotomy. It is preferrable to locate the testing axotomy far enough proximal to the conditioning axotomy that the intervening segment of nerve is sufficiently long to permit measuring the outgrowth rate.

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  1. Veterans Administration Medical Center and Department of Anatomy and Developmental Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Irvine G. McQuarrie

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  1. Florida State University, Tallahassee, Florida, USA

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McQuarrie, I.G. (1984). Effect of a Conditioning Lesion on Axonal Transport During Regeneration. In: Elam, J.S., Cancalon, P. (eds) Axonal Transport in Neuronal Growth and Regeneration. Advances in Neurochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1197-3_12

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  • DOI: https://doi.org/10.1007/978-1-4684-1197-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1199-7

  • Online ISBN: 978-1-4684-1197-3

  • eBook Packages: Springer Book Archive

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