Abstract
This chapter represents a general review of the relationship of transport to regeneration. Views of how nerves regenerate have for some time been connected with the concept that transport supplies the materials required by the growing fibers. At first, when only slow transport was known, the similarity of the rates of transport and of regeneration at approximately several millimeters per day appeared to indicate their direct association. The more recent recognition of a faster rate of axoplasmic transport raised the question of how rapid transport might be related to regeneration. Currently, two general views are held: (1) that there is more than one transport system present in nerve fibers, one for slow transport, which is mainly responsible for the outgrowth of the major structural elements of the fiber, and another system mainly responsible for the rapid transport of membranous constituents of the axon and nerve terminal processes, and (2) that both rapid and slow transport are accomplished by one transport mechanism, a concept termed the “unitary hypothesis.” In this chapter, I present an analysis of how the components needed for regeneration can be supplied on the basis of the unitary hypothesis. Another aspect of regeneration that is related to the transport mechanism is how a supply of materials can be provided to one subset of neuntes growing or regenerating from a single neuron rather than to all the neurite branches supplied by the cell body. As is discussed below, this is entailed in the phenomenon of “routing,” which can be accounted for by the same transport mechanism.
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Ochs, S. (1984). Axoplasmic Transport in Relation to Nerve Fiber Regeneration. In: Elam, J.S., Cancalon, P. (eds) Axonal Transport in Neuronal Growth and Regeneration. Advances in Neurochemistry, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1197-3_1
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