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Cell Death in Neuronal Development

Regulation by Trophic Factors

  • Chapter
Neuronal Development

Part of the book series: Current Topics in Neurobiology ((CTNB))

Abstract

Neuronal death has been identified as a widely occurring phenomenon in the development of the vertebrate nervous system. More than half of the cells initially present in such populations as the motoneuron pool of the spinal cord and neurons of autonomic and sensory ganglia disappear during embryonic development. The number of surviving neurons appears to depend on the amount of target tissue available for innervation by the neurons. Removal of the target tissue prior to the period of cell death causes nearly all of the neurons to die subsequently, while transplantation of additional tissue to the embryo to serve as a potential target for the neurons permits more neurons to survive through the normal die-off period.

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Authors and Affiliations

  1. Department of Biology, University of California, San Diego, La Jolla, CA, 92093, USA

    Darwin K. Berg

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  1. Darwin K. Berg
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  1. University of California, San Diego, La Jolla, California, USA

    Nicholas C. Spitzer

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© 1982 Plenum Press, New York

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Berg, D.K. (1982). Cell Death in Neuronal Development. In: Spitzer, N.C. (eds) Neuronal Development. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1131-7_9

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  • DOI: https://doi.org/10.1007/978-1-4684-1131-7_9

  • Publisher Name: Springer, Boston, MA

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