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Effects of Insecticides on the Sensory Nervous System

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Book cover Neurotoxicology of Insecticides and Pheromones

Abstract

The majority of insecticidal chemicals owe their toxicity to the ability to interfere with the function of the nervous system. For organophosphates and carbamates it is well established that their action on the nervous system is primarily due to inhibition of the enzyme acetylcholinesterase, resulting in a disturbance of cholinergic synaptic transmission. For other insecticides, notably DDT and its derivatives and pyrethroids, such a biochemical mode of action has not been established. It is now generally accepted that these latter compounds act directly on excitable tissues and interfere with the changes in ionic permeability of the nerve membrane that underlie the generation and conduction of the nervous impulse (1, 2).

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Author information

Authors and Affiliations

  1. Institute of Veterinary Pharmacology and Toxicology, University of Utrecht, Biltstraat 172, Utrecht, The Netherlands

    Joep van den Bercken, Alfons B. A. Kroese & Louis M. A. Akkermans

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  1. Joep van den Bercken
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  2. Alfons B. A. Kroese
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  3. Louis M. A. Akkermans
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Editors and Affiliations

  1. Department of Pharmacology, Medical School, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA

    Toshio Narahashi

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© 1979 Plenum Press, New York

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van den Bercken, J., Kroese, A.B.A., Akkermans, L.M.A. (1979). Effects of Insecticides on the Sensory Nervous System. In: Narahashi, T. (eds) Neurotoxicology of Insecticides and Pheromones. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0970-3_10

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  • DOI: https://doi.org/10.1007/978-1-4684-0970-3_10

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