Abstract
In a comprehensive survey of contamination of the human environment by potentially hazardous polynuclears, GUNTHER and BUZZETTI ( 1965 ) dealt primarily with the analytical problems and special aspects of isolating and determining specific members of this class of compounds. The development of analytical control of such potential contaminants in food and food additives has not, however, been reviewed comprehensively. For adequate control, the analytical requirements are dictated by the toxicological significance of the contaminants and by the extent of the potential exposure of the consumer, that is, the specific food products concerned, their dietary significance, and their liability to contamination. The special toxicological and regulatory problems associated with the control of carcinogenic contaminants, particularly “weak carcinogens,” have been reviewed by Oser (1962). RAMSEY (1967) reviewed the contribution to the analytical problem of zero residues provided by a more recent amendment to the Food Additives Amendment of 1958. He points out that although it provides only a partial resolution of the general problem, the new amendment nevertheless establishes a practical statutory guideline by defining “no residue” in terms of an adequate method of examination. Thus, whenever the law requires that safe conditions of use for a food additive must be established by regulation, the conditions in the regulation may be framed in such a way that any deleterious substances occurring in food as a result of use of the additive will, in effect, be limited to negligible (toxicologkally insignificant) quantities. Accordingly, no matter how minute the toxicologically insignificant quantity of a substance, it is finite and therefore definable in terms of an acceptable method of determination.
Keywords
- Polycyclic Aromatic Hydrocarbon
- American Petroleum Institute
- Polycyclic Hydrocarbon
- Ultraviolet Absorbance
- German Federal Republic
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Hereinafter designated polynuclears in conformance with prior practice in this book series.
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References
Bailey, E. J., and N. Dungal: Polycydic hydrocarbons in Icelandic smoked foods. Brit. J. Cancer 12, 348 (1958).
Bergert, K. H., M. Koehler, and H. Schumacher: Determination of 3,4-benzopyrene in bread cereals. Z. Anal. Chem. 208 (1), 44 (1965); through Chem.Abstr. 62, 11062e (1965).
Bulling, H.: Carcinogenic substances in cereals dried with combustion gas. Tec. Molitoria 15 (24), 137 (1964); through Chem. Abstr. 62, 16878h (1965).
Borneff, J., and B. Fabian: Kanzerogene Substanzen in Speisefett und—öl. Arch. Hyg. Bakteriol. 150, 485 (1966).
—, and R. Fischer: Determination of polycyclic aromatic hydrocarbons in the phytoplankton of a lake. Arch. Hyg. Bakteriol. 146, 334 (1962); through Chem. Abstr. 58, 1179h (1963).
Commins, B. T., and P. J. Lawther: Volatility of 3,4-benzpyrene in relation to the collection of smoke samples. Brit. J. Cancer 12, 351 (1958).
Dietz, W. A., W. H. King, Jr., W. Priestley, Jr., and J. Rehner, Jr.: Properties of high boiling petroleum products. Carcinogenkity studies. Ind. and Eng. Chem. 44, 1818 (1952).
Dikun, P. P.: Determination of low 3,4-benzopyrene concentrations by fine-structure fluorescent spectrum. Vopr. Onkol. 7 (7), 42 (1961); through Chem. Abstr. 56, 658i (1962).
— Determination of polycyclic hydrocarbons in smoked fish by means of the fine structure of fluorescent spectra. Vopr. Onkol. 11 (2), 77 (1965 a); through Chem. Abstr. 62, 15349f (1965).
— Content of carcinogens in smoke and smoked products. Rybn. Khoz. 41 (3), 60 (1965 b); through Chem. Abstr. 63, 7574h (1965).
—, A. A. Llverovskii, E. I. Shmulevskaya, N. D. Gorelova, L. N. Parfent’Eva, and R. M. Vzdornikova: The presence of polycyclic hydrocarbons in the products of wood pyrolysis at 300–600°C. Sovrem. Probl. Onkol. Sb. (Leningrad: Meditsina) 1965, 48; through Chem. Abstr. 65, 12406 (1966).
Dobes, M., K. Hopp, and J. Sula: Examination of smoked food for the presence of benzo(a)pyrene. Ceskoslov. Onkol. 1, 254 (1954); through Chem. Abstr. 49, 4199 (1955).
Doerr, R.: Alkaloid and benzopyrene uptake by intact plant roots. Naturwissenschaften 52 (7), 166 (1965); through Chem. Abstr. 62, 16635a (1965).
Draudt, H. N.: The meat smoking process: A review. Food Technol. 17 (12), 85 (1963).
Druckrey, H., D. Schmael, and R. Preussmann: Fluoreszierende Verunreinigungen bei Paraflinum liquidum und organischen Lösungsmitteln. Arzneimittelforsch. 9, 600 (1959).
Elchoff, H. J., and G. Titschack: Characterization of hydrocarbon waxes by fluorescence spectroscopy. Erdöl. Kohle 11, 795 (1958); through Chem. Abstr. 53, 3674e (1959).
Falk, H. L., P. Kotin. and A. Miller: Milk as an eluent of polycyclic aromatic hydrocarbons added to wax. Nature 183, 1184 (1959).
Fischer, K., G. Brandes, and W. Gohdes: Determination of aromatic compounds in mineral oils for medical use. Pharm. Ind. 19, 292 (1957); through Chem. Abstr. 52, 14082e (1958).
Fritz, W.: Automatic recorder of fluorescence spectra. Chem. Tech. (Berlin) 18 (11), 689 (1966); through Chem. Abstr. 66, 75108n (1967).
Gandolfo, N., A. Sampaolo, and E. Verdino: Criteri per stabilire i requisiti di purezza delie paraffine da impiegare in contatto con alimenti. Rass. Chim. 6, 283 (1966).
Germany (Federal Republic) : Ordinance concerning the addition of foreign substances in the treatment of fruit and fruit products. Bundesgesetzblatt I, No. 52, 751 (Dec. 22, 1959 a); through Food and Agricultural Legislation IX (3), 1961.
— Ordinance on the permissibility of additives in the manufacture of chewing gum. Bundesgestzblatt I, No. 52, 754 (Dec. 19, 1959 b); through Food and Agricultural Legislation IX (3), 1961.
— Gesundheitliche Beurteilung von Kunststoffen im Rahmen des Lebensmittelgeset zes, 17 Mitt. XXV Paraffine, mikrokristalline Wachse, niedermolekulare Polyolefine und Polyterpene. Bundesgesundheitsblatt 1964 a (9), p. 136.
— Untersuchung von Kunststoffen, soweit sie als Bedarfsgegenstande im Sinne des Lebensmittelgesetzes verwendet werden, 5 Mitt., Prüfung von Hartparaffinen und mikrokristallinen Wachsen auf alkalisch oder sauer reagierende Verunreinigungen, auf das Verhalten gegen Schwefelsäure und auf cancerogene polycyclische Kohlenwasserstoffe. Bundesgesundheitsblatt 1964 b (9), p. 137.
Gorelova, N. D., P. P. Dlkun, and I. I. Lapshin: 3,4-Benzopyrene in liquids used in the process of fish smoking. Vopr. Onkol. 5, 341 (1959); through Chem. Abstr. 54, 11324c (I960).
— —, V. A. Solinek, and A. V. Emshanova: The 3,4-benzopyrene content of fish smoked by different processes. Vopr. Onkol. 6, (1), 33 (1960); through Chem. Abstr. 55, 48l4h (1961).
— —, O. P. Gretskaya, and A. V. Emshanova: Content of 3,4-benzopyrene in smoked soka and in the smoke soot of different methods of fish smoking. Vopr. Onkol. 9 (3), 53 (1963 a); through Chem. Abstr. 59, 6905h (1963).
----Content of 3,4-benzopyrene in sprats cured with smoke from a friction smoke generator or smoke generator PSM Vniro. Vopr. Onkol. 9 (8), 77 (1963 b); through Chem. Abstr. 59, 15862 (1963).
--Concentration of 3,4-benzpyrene in paraffins at different degree of purification. Vopr. Onkol. 11 (3), 115 (1965 a); through Chem. Abstr. 63, 1633c (1965).
--3,4-Benzopyrene content of sausage and smoked fish prepared using fuel gas and coke. Gigienta i Sank. 30 (7), 120 (1965 b); through Chem. Abstr. 63, 10574e (1965).
----, A. N. Aksenova, and B. Elenich: Effect of filtration on the concentration of 3,4-benzopyrene in curing smoke and in smoked products. Vopr. Onkol. 12 (9), 80 (1966); through Chem. Abstr. 65, 20751g (1966).
Graf, W., and H. Dlehl: The natural normal levels of carcinogenic polycyclic aromatic hydrocarbons and the reasons therefor. Arch. Hyg. Bakteriol. 150 (1–2), 49 (1966); through Chem. Abstr. 65, 7604h (1966).
Grimmer, G.: Quantitative Bestimmung von merhrkernigen Aromaten in Paraffinum liquidum. Erdöl Kohle 13, 960 (I960).
-, and A. Hildebrandt: Kohlenwasserstoffe in der Umgebung des Menschen. I. Mitt. Eine Methode zur simultanen Bestimmung von dreizehn polycyclischen Kohlenwasserstoffen. J. Chromatog. 20, 89 (1965 a).
--Hydrocarbons in the human environment. IL Content of polycyclic hydrocarbons in bread grains from various localities. Z. Krebsforsch. 67, 272 (1965 b); through Chem. Abstr. 64, 7272g (1966).
--Content of polycyclic hydrocarbons in different vegetables. III. Hydrocarbons in the human surroundings. Deut. Lebensm. Rundschau 61 (8), 237 (1965 c); through Chem. Abstr. 63, 16769g (1965).
--Hydrocarbons in the human environment. IV. Polycyclic hydrocarbons in coffee and tea. Deut. Lebensm. Rundschau 62 (1), 19 (1966); through Anal. Abstr. 14 (6), 3591 (1966).
Günther, F. A., and F. Buzzetti: Occurrence, isolation, and identification of polynuclear hydrocarbons as residues. Residue Reviews 9, 90 (1965).
--, and W. E. Westlake: Residue behavior of polynuclear hydrocarbons on and in oranges. Residue Reviews 17, 81 (1967).
Haenni, E. O., and M. A. Hall: Tentative ultraviolet absorption limits for mineral oils. J. Assoc. Official Agr. Chemists 43, 92 (I960).
-,F. L. Joe, J. W. Howard, and R. L. Leibel: A more sensitive and selective ultraviolet absorption criterion for mineral oil. J. Assoc. Official Agr Chemists 45, 59 (1962 a).
-,J. W. Howard, and F. L. Joe: Dimethyl sulfoxide: A superior analytical extraction solvent for polynuclear hydrocarbons and for some highly chlorinated hydrocarbons. J. Assoc. Official Agr. Chemists 45, 67 (1962 b).
Helberg, D.: Papierchromatographischer Nachweis von polycyclischen Kohlenwasserstoffen in Paraffinen und mikrokristallinen Wachsen. Deut. Lebensm. Rundschau 11, 321 (1962).
- Prüfung von Paraffinen und mikrokristallinen Wachsen auf cancerogene polycyclishe aromatische Kohlenwasserstoffe. Deut. Lebensm. Rundschau 60 (11), 345 (1964).
Hoffmann, D., and E. L. Wynder: Short-term determination of carcinogenic aromatic hydrocarbons. Anal. Chem. 32, 295 (1960).
Hollenbeck, C. N., and L. V. Marinelli: Some chemical constituents of smoke flavoring. Proc. Research Conf. Advisory Council Research Amer. Meat Inst. Foundation, Univ. Chicago 15, 67 (1963).
Howard, J. W.: Private communication (1962).
- Collaborative study of method for benzo(a)pyrene in smoked foods. Presented Annual Meeting, Assoc. Official Anal. Chemists, Washington, D.C. (Oct. 1967), submitted for publication J. Assoc. Official Anal. Chemists (1967 a).
- Private communication (1967 b).
-, and E. O. Haenni: The extraction and determination of polynuclear hydrocarbons in paraffin waxes. J. Assoc. Official Agr. Chemists 46. 933 (1963).
--, and F. L. Joe: An ultraviolet absorption criterion for total polynuclear aromatic hydrocarbon content of petroleum waxes in food additive use. J. Assoc. Official Agr. Chemists 48, 304 (1965).
-, and R. T. Teague : Extraction and estimation of polycyclic aromatic hydrocarbons added to milk. J. Assoc. Official Agr. Chemists 48, 315 (1965).
--, R. H. White, and B. E. Fry, Jr.: Extraction and estimation of polycyclic aromatic hydrocarbons in smoked foods. I. General method. J. Assoc. Official Anal. Chemists 49, 595 (1966 a)
-, R. H. White, B. E. Fry, and E. W. Turicchi: Extraction and estimation of polycyclic aromatic hydrocarbons in smoked foods. II. Benzo(a)pyrene. J. Assoc. Official Anal. Chemists 49, 611 (1966 b).
-,E. W. Turicchi, R. H. White, and T. Fazio: Extraction and estimation of polycyclic aromatic hydrocarbons in vegetable oils. J Assoc. Official Anal. Chemists 49, 1236 (1966 c).
-, R. H. White, and C. J. Barnes: Extraction and estimation of polycyclic aromatic hydrocarbons in liquid smoke flavorings. In preparation (1967).
-,T. Fazio, and R. H. White: Polycyclic aromatic hydrocarbons in solvents used in extraction of edible oils. J. Agr. Food Chem. 16, 72 (1968 a).
---, and B. A. Klimeck: Extraction and estimation of polycyclic aromatic hydrocarbons in total diet composites. J. Assoc. Official Anal. Chemists 51, 122 (1968 b).
Jaforte, A., and A. Cavallaro: Determination of 3,4-benzopyrene and other polycyclic hydrocarbons in paraffins. Riv. Ital. Sostanze Grasse 42 (8), 391 (1965).
Kaufmann, B. D., A. J. Mlronowa, and L. M. Szobod: Vopr. Onkol. 5, 314 (1959); cited by D. J. Tilgner and K. Mller: Przemysl Spozywczy 17 (2), 17 (1963).
Knorr, M.: Vapor pressure of solid carcinogenic aromatic hydrocarbons. Arch. Hyg. Bakteriol. 150 (1–2), 59 (1966); through Chem. Abstr. 65, 9610c (1966).
Lijinsky, W.: Separation of polycyclic aromatic hydrocarbons in complex mixtures: Chromatographic determination of trace amounts in petroleum waxes. Anal. Chem. 32, 684 (1960).
-, and C. R. Raha: Polycyclic aromatic hydrocarbons in commercial solvents. Tox-icol. Applied Pharmacol. 3, 469 (1961).
--, and J. Keeling: Comparison of procedures for the determination of polycyclic aromatic hydrocarbons in waxes. Anal. Chem. 33, 810 (1961).
- Personal communication (1962).
-,I. Domsky, and C. R. Raha: A short method of testing petroleum waxes for the presence of polycyclic aromatic hydrocarbons. J. Assoc. Official Agr. Chemists 49, 725 (1963).
-, and P. Shubik: The detection of polycyclic aromatic hydrocarbons in liquid smoke and some foods. Toxicol. Applied Pharmacol. 7 (2), 337 (1965 a).
--Polynuclear hydrocarbon carcinogens in cooked meat and smoked food. Ind. Med. Surg. 34 (2), 152 (1965 b).
-, I. I. Domsky, and J. Ward: Detection of carcinogenic polynuclear hydrocarbons in petroleum waxes using electron capture. J. Gas Chromatog. 3 (5), 152 (1965 a).
-, and J. Ward: Qualitative and quantitative analysis of mixtures of polynuclear compounds by gas chromatography using a fraction collector. Develop. Applied Spectroscopy 5, 411 (1965 b).
Mallet, L.: Pollution of earth and vegetation with 3,4-benzopyrene-type hydrocarbons. Congr. Expertise Chim., Vol. Spec. Conf. Commun., 4th, Athens, 1964, p. 301; through Chem. Abstr. 66, 84240b (1967).
-, and M. L. Priou: Retention of polybenzene hydrocarbons of the 3,4-benzopyrene-type by the sediments and the marine fauna and flora of Saint Malo Bay. C R. Acad. Sci. Paris, Sev. D. 264 (7), 969 (1967); through Chem. Abstr. 66, 108064a (1967).
Masuda, Y., K. Mori, and M. Kuratsune: Polycyclic aromatic hydrocarbons in common Japanese foods. I. Broiled fish, roasted barley, shoyu, and caramel. Gann 57, 133 (1966); through Chem. Abstr. 65, 2891 (1966).
---Polycyclic aromatic hydrocarbons formed by pyrolysis of carbohydrates, acids, and fatty acids. Gann 58 (1), 69 (1967); through Chem. Abstr. 66, 101787e (1967).
Mazee, W. M., H. R. Gersmann, and A. Van Der Wlel: Analysis of polycyclic aromatic hydrocarbons in petroleum waxes and white mineral oils with appraisal of merits of different methods of analysis. Food Cosmetic Toxicol. 4, 17 (1966).
McLeod, D. G. (Torry Research Station, Aberdeen, Scotland) : private communication (1966).
Moore, G. E., J. L. Monkman, and M. Ratz: Some problems concerning analysis of polycyclic hydrocarbons in particulate pollution samples. In: Analysis of carcinogenic air pollutants. Nat. Cancer Inst. Monograph No. 9, p. 153 (1962).
Narziss, L., H. Kieninger, and E. Reicheneder: Bestimmung von 3,4-Benzpyren in Bier. Brauwissenschaft 19 (7), 284 (1966).
Nugmanov, S. N., N. D. Gorelova, and P. P. Dlkun: 3,4-Benzopyrene content in domestically smoked Kazakh food products. Vopr. Onkol. 7 (2), 41 (1961); through Chem. Abstr. 55, 1269li (1961).
Oser, B. L.: The experimental induction of cancer by pesticide residues and food additives: Its rationale and interpretation. Residue Reviews 1, 1 (1962).
Petrun, A. S., and B. L. Rubenchik: Possibility of carcinogenic 3,4-benzopyrene in electrostatically smoked fish. Vrachebnoe Delo 1966 (2), p. 93; through Chem. Abstr. 64, 20517h (1966).
Ramsey, L. L.: Analytical methods and the preclearance food protection amendments to the FD&C Act. J. Assoc. Official Anal. Chemists 50, 1013 (1967).
Rondia, D.: Volatility of polycyclic hydrocarbons. Air Water Pollution9 (3), 113 (1965); through Chem. Abstr. 63, 7554d (1965).
Ryder, J. W., and G. P. Sullivan: Analysis of non-volatile material in solvent hexane. J. Amer. Oil Chemists’ Soc. 39, 263 (1962).
Sacclni-Clcatelll, M.: Storage of 3,4-benzopyrene in Tubifex worms. Boll. Pesca, Piscicolt, Idrobiol. 20, (2), 545 (1965); through Chem. Abstr. 66, 1730n (1967).
- Accumulation of 3,4-benzopyrene in Tubifex. Boll. Soc. Ital. Biol. Sper. 42 (15), 957 (1966); through Chem. Abstr. 66, 26880z (1967).
Seppilli, A., and G. Scassellati-Sforzolini: Sulla presenza di idrocarburi policiclici cancerigeni nelle carni cotte alla graticola. Boll. Soc. Ital. Biol. Ser. 39, 110 (1963).
Shabad, L. M., and A. Ya. Khesina: Determination of 3,4-benzopyrene in highly pure industrial paraffins by luminescence spectroscopy. Zavodsk. Lab. 31 (11), 1345 (1965); through Chem. Abstr. 64, 5757a (1965).
Shubik, P.: Private communication (1961).
-, U. Saffiotti, W. Lijinsky, G. Pietra, H. Rapport, B. Toth, C. R. Raha, L. Tomatls, R. Feldman, and H. Ramahi: Studies on the toxicity of petroleum waxes. Toxicol. Applied Pharmacol. 4, (Supplement), 1 (1962).
Slkorskl, Z. E., and D. J. Tllgner: Über Räucherrauchverfahren. I. Mitteilung jetziger Stand der chemischen Räucherrauchanalyse. Z. Lebensmitt-Untersuch. 124, 274 (1964).
- Chemical changes in curing smoke in a field of corona discharges. Zeszyty Naukowe Politechniki Gdanskiej 69, 3 (1965).
Tllgner, D. J.: Smoke curing processes. Fleischwirtschaft 10, 649 (1958).
-,and H. Daun: Influence of cellulose and lignin on the presence of carcinogens in curing smoke. Roczniki Panstwowego Zakladu Hig. 16 (1), 45 (1965); through Chem. Abstr. 62, 16742h (1965).
Tltschack, G.: Die gesetzlichen Verordnungen über Reinheitsanforderungen fur Paraffin, Microwachse in den verschiedenen Landern. Nahrung 6 (1), 77 (1966).
United Kingdom: The mineral hydrocarbons in food regulations 1966, Statutory Instrument 1966 No. 1073, Food and Drugs, Composition, August 27, 1966;Her Majesty’s Stationery Office, London (1966).
United States: Code of Federal Regulations; Title 21—Food and Drugs; Pts. 1–129 (Revised as of Jan. 1, 1967) Pt. 121, Food Additives. U. S. Government Printing Office, Washington, D. C. (1967).
Voskresenskii, N. A.: Electric smoking, a very promising method for smoking fish. Novye Fiz. Metody Obrabotki Pishchevykh Produktor, Kiev, 5b. 1963, p. 7; through Chem. Abstr. 62, 9695a (1965).
Wojtelowicz, F. A., P. P. Dlkun, and L. M. Szobod: Vopr. Onkol. 3, 351 (1957); cited by D. J. Tilgner and K. Miler: Przemysl Spozywczy 17 (2), 17 (1963).
General Sources
Current Food Additive Legislation: Food and Agriculture Organization of the United Nations, Rome, Italy.
Food And Agricultural Legislation: Food and Agricultural Organization of the United Nations, Rome, Italy.
Food Chemicals Codex: 1st ed. Publication 1406. Washington, D.C.: National Academy of Sciences—National Research Council.
Food Drug Cosmetic Law Journal: Commerce Clearing House, Inc., Chicago, Illinois.
International Digest Of Health Legislation: World Health Organization, Geneva, Switzerland.
Latin-American Food Code: Latin-American Food Council. English translation, Food Drug Cosmetic Law J. 20 (1965).
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Haenni, E.O. (1968). Analytical control of polycyclic aromatic hydrocarbons in food and food additives. In: Gunther, F.A. (eds) Residue Reviews / Rückstands-Berichte. Residue Reviews / Rückstands-Berichte, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-8440-7_3
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