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Cotranslational Folding and Transmembrane Transport of Proteins

  • Chapter
Ribosomes

Part of the book series: Cellular Organelles ((CORG))

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Abstract

The polypeptide chain on the ribosome elongates by consecutive growth from the N-terminus to the C-terminus. During growth, the C-terminus is covalently fixed in the ribosomal PTC, whereas the N-terminus is free. Obviously, the free N-terminal region of the nascent polypeptide chain must acquire some conformation. This implies that while the protein is being synthesized on the ribosome, it undergoes some folding that begins from its N-terminal part.

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  1. Russian Academy of Sciences, Moscow, Russia

    Alexander S. Spirin

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  1. Alexander S. Spirin
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© 1999 Kluwer Academic/Plenum Publishers, New York

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Spirin, A.S. (1999). Cotranslational Folding and Transmembrane Transport of Proteins. In: Ribosomes. Cellular Organelles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7817-8_18

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  • DOI: https://doi.org/10.1007/978-1-4615-7817-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46146-0

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