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Absorption, Diffusion, Distribution, and Elimination of Ethanol: Effects on Biological Membranes

  • Chapter
The Biology of Alcoholism

Abstract

The basic facts of alcohol absorption, distribution, metabolism, and excretion were described clearly many years ago by Nicloux (1900) and Gréhant (1907), among others. They showed that alcohol could be absorbed from the stomach or by inhalation in the lungs, distributed throughout the body fluids and tissues via the blood, eliminated only slowly via the lungs, kidneys, and skin, and removed chiefly by slow metabolic oxidation. Later work by a multitude of investigators has clarified the mechanisms, the quantitative relationships, and the influence of various physiological, pathological, and pharmacological factors upon these processes. Many excellent reviews and major studies were written at various stages in the development of knowledge in this field, including those by Mellanby (1919), Kochmann (1923), Miles (1924), Carpenter (1929), LeBreton (1934), Newman (1941), Goldberg (1943), Casier and Delaunois (1947), Elbel and Schleyer (1956), Himwich (1956), Harger and Forney (1963), and Mardones (1963).

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  1. Department of Pharmacology, Alcoholism and Drug Addiction Research Foundation, University of Toronto, Toronto, Ontario, Canada

    Harold Kalant

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  1. Division of Alcoholism and Drug Dependence Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York, USA

    Benjamin Kissin  & Henri Begleiter  & 

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Kalant, H. (1971). Absorption, Diffusion, Distribution, and Elimination of Ethanol: Effects on Biological Membranes. In: Kissin, B., Begleiter, H. (eds) The Biology of Alcoholism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6525-3_1

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