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The functions of Myc in cell cycle progression and apoptosis

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

c-myc has emerged as one of the central regulators of mammalian cell proliferation. The gene encodes a transcription factor of the HLH/leucine zipper family of proteins that activates transcription as part of a heteromeric complex with a protein termed Max. In mammalian fibroblasts, Myc acts as an upstream regulator of cyclin-dependent kinases and functionally antagonises the action of at least one cdk inhibitor, p27. Myc also induces cells to undergo apoptosis, and the relationship between Myc-induced cell cycle entry and apoptosis is discussed.

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Authors and Affiliations

  1. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, 69120, Heidelberg, Germany

    Philipp Steiner

  2. Whitehead Center for Medical Research, 9 Cambridge Center, Cambridge, USA

    Bettina Rudolph, Daniel Müller & Martin Eilers

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  1. Philipp Steiner
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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Steiner, P., Rudolph, B., Müller, D., Eilers, M. (1996). The functions of Myc in cell cycle progression and apoptosis. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_7

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