Abstract
Activators of PKC in combination with vanadate induce massive formation of reactive oxygen species. The formation of ROS leads to suppression of protein tyrosine phosphatase activity and consequently to enhanced protein tyrosine phosphorylation. This culminates in the activation of the MAP-K cascade and of PLA2 (Scheme 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ames, B.N., Hagen, T.M. and Shigenaga, M.K. (1991) In: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, (S. Nigam, K.V. Honn, L.J. Marnett. and T.L. Waiden Jr., eds.), 2nd Annual Conference, Berlin, Kluwer Academic Publishers, pp. 383–385.
Thun, M.J., Namboodiri, M.M., Calle, E.E., Flanders, D. and Heath Jr., C.W. Cancer Res. 53:1322–1327, 1993.
Goldman, R., Ferber, E. and Zor, U. FEBS Lett. 309:190–192, 1992.
Zor, U., Ferber, E., Gergely, P., Szucs, K., Dombradi, V. and Goldman, R. Biochem. J. 295:879–888, 1993.
Goldman, R., Ferber, E., Meiler, R. and Zor, U. (1993) Biochim. Biophys. Acta, In Press.
Hecht, D. and Zick, Y. Biochem. Biophys. Res. Commun. 188:773–779, 1992.
Lin, L.L., Wartmann, M., Lin, A.Y., Knopf, J.L., Seth, A. and Davis, R.J. cPLA2 is phosphorylated and activated by MAP kinase. Cell 72:269–278, 1993.
Nemenoff, R.A., Winitz, S., Qian, N.X., Putten, V.V., Johnson, G.L. and Heasley, L.E. J. Biol. Chem. 268:1960–1964, 1993.
Tauber, A.I. Blood 69:711–720, 1987.
Yarden, Y. and Ullrich, A. Ann. Rev. Biochem 57:443–478, 1988.
Ullrich, A. and Schlessinger, J. Cell 61:203–212, 1990.
Rose, R.C. and Bode, A.M. FASEB J. 7:1135–1142, 1993.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Goldman, R., Ferber, E., Zor, U. (1997). Involvement of Reactive Oxygen Species in Phospholipase A2 Activation: Inhibition of Protein Tyrosine Phosphatases and Activation of Protein Kinases. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5325-0_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7430-5
Online ISBN: 978-1-4615-5325-0
eBook Packages: Springer Book Archive