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Perspectives of Capsaicin-Type Agents in Pain Therapy and Research

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Contemporary Issues in Chronic Pain Management

Part of the book series: Current Management of Pain ((CUMP,volume 9))

Abstract

There is a “ painfully” absent chapter in pharmacological textbooks, which could be entitled: “Drugs acting on sensory neurons” or “Sensory neuron-blocking analgesics.” For over 100 years, varieties of narcotic analgesics, analgesic-antipyretics, and local anesthetics have provided the repertoire of drugs used for pain management. In contrast to effector neurons (particularly their peripheral neurotransmission processes, which have become multiple targets for drug development), sensory neurons and their receptors have remained almost unexplored as sites for the selective action of drugs in clinical practice. The main reason for this situation resides in a very simple fact. In the field of neuroeffector transmissions, delicate molecules produced by nature, such as curare, ergot alkaloids, or atropine, had served as excellent guides by highlighting special features of each neural mechanism as suitable sites for selective blockade and possible starting points for further drug development. Similar approaches in sensory pharmacology, however, have received less attention.

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Authors
  1. Janos Szolcsanyi
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  1. Vanderbilt University, Nashville, TN, 37232, USA

    Winston C. V. Parris

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© 1991 Springer Science+Business Media New York

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Szolcsanyi, J. (1991). Perspectives of Capsaicin-Type Agents in Pain Therapy and Research. In: Parris, W.C.V. (eds) Contemporary Issues in Chronic Pain Management. Current Management of Pain, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3888-2_8

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  • DOI: https://doi.org/10.1007/978-1-4615-3888-2_8

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