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Mitogenic Effects of Eicosanoids in Human Airway Epithelial Cells

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Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 67))

Abstract

Uncontrolled epithelial cell growth is a hallmark of many forms of cancer and, in the lung, the airway epithelium represents an important target site for initiation by environmental agents (1). Epithelial proliferation and hyperplasia are common sequelae of chronic irritation and inflammation, and thus have been linked to the promotion phase in multistage carcinogenesis (2). Understanding the local processes that provide a micro-environment selective for clonal explanation of pre-carcinogenic cells could therefore be useful in evaluating the complex relationships between inflammation and cancer.

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Author information

Authors and Affiliations

  1. Pulmonary Cell Biology Laboratory, Departments of Environmental Health, and Physiology and Biophysics, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267-0182, USA

    G. D. Leikauf, H.-E. Claesson, C. A. Doupnik & R. G. Grafstrom

  2. Departments of Toxicology and Physiological Chemistry, Karolinska Institut, Stockholm, Sweden, S104-01

    G. D. Leikauf, H.-E. Claesson, C. A. Doupnik & R. G. Grafstrom

Authors
  1. G. D. Leikauf
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  2. H.-E. Claesson
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  3. C. A. Doupnik
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  4. R. G. Grafstrom
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  2. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  3. Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

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© 1991 Springer Science+Business Media New York

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Leikauf, G.D., Claesson, HE., Doupnik, C.A., Grafstrom, R.G. (1991). Mitogenic Effects of Eicosanoids in Human Airway Epithelial Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_47

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  • DOI: https://doi.org/10.1007/978-1-4615-3874-5_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6727-7

  • Online ISBN: 978-1-4615-3874-5

  • eBook Packages: Springer Book Archive

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