Abstract
Chemotherapy has proven to be an effective treatment for the cure and palliation of some human cancers (Chabner, 1982). Some tumors, however, appear to be intrinsically resistant to chemotherapy. For cancers that can be treated with chemotherapy, based on the hypothesis that resistance to single agents occurs with high frequency, protocols involving multiple drugs with different intracellular targets have been designed. In many cases, such as acute lymphocytic leukemia and neuroblastoma (Simone et al., 1982), Hodgkin’s disease (De-Vita and Hellman, 1982), and germ cell cancers (Paulson et al., 1982), dramatic results have been achieved with such protocols. However, all too frequently relapse occurs after such therapy and the recurrent tumors are resistant to further chemotherapy. In effect, such tumors develop a multidrug resistance (MDR) phenotype that is very similar to the intrinsic resistance of some primary cancers.
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Gottesman, M.M., Goldstein, L.J., Fojo, A., Galski, H., Pastan, I. (1991). Expression of the Multidrug Resistance Gene in Human Cancer. In: Roninson, I.B. (eds) Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3794-6_15
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DOI: https://doi.org/10.1007/978-1-4615-3794-6_15
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