Abstract
Oxidants may be natural carcinogens and contribute to several stages of malignant transformation. Active oxygen released by inflammatory phagocytes may induce mutations in protooncogenes and tumor suppressor genes in neighbouring target cells. In addition, oxidants can promote cell growth. Like polypetide growth factors they activate kinases. Because they break DNA, they also induce the poly ADP-ribosylation of chromosomal proteins. Both phosphorylation and poly ADP-ribosylation appear to participate in the transcriptional induction of the growth-related protooncogene c-fos. Growth stimulation by oxidants is modulated by the cellular antioxidant defenses. Maximal growth promotion is observed when cells are protected from excessive toxicity but still maintain a sufficient oxidant signal for the induction of growth-competence genes.
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References
Cerutti P. Science 227:375–381 1985.
Kozumbo W. Trush M. Kensler T. Chem. Biol. Inter. 54:199–207 1985.
Cerutti P. and Trump B. Cancer Cells 3:1–7 1991.
See in Oxy-radicals in Molecular Biology and Pathology (Eds. P. Cerutti I. Fridovich and J. McCord New York; Alan R. Liss 1988).
Creasia D. Nettesheim P. Particulates and Chronic Inflammation Increase Rates of Carcinogenesis In: Experimental lung cancer (Eds. E. Karbe and J. Park 234–235 New York: Springer Verlag; 1974 pp. 234-235).
See in Cancer of the Respiratory Tract (Eds. M. Mass D. Kaufman J. Siegfried V. Steele S. Nesnow Raven Press New York. V. Feron et al pp 93–118 and B. Mossman et al 1985) pp. 17-238.
Alexander-Williams J. Colon Rectum 19:579–581 1976.
Argyris T. Slaga T. Cancer Res. 41:5193–5195 1981.
See in Perspectives in Inflammation Neoplasia and Vascular Cell Biology (Eds. T. Edington R. Ross and S. Silverstein, New York Alan R. Liss) 1987.
Menkes M. Comstock G. Vuilleumier J. Helsing K. Rider A. Brookmeyer R. New Engl. J. Med. 315:1250–1254 1986.
Gey F. Am. J. Nutr. 45:1368–1377 1987.
Slaga T. Sollnki V. Logani M. Studies on the mechanism of action o~ antitumor promoting agents: Suggestive evidence for the involvement of free radicals in promotion. In: Radioprotectors and Anticarcinogens (Eds O. Nygaard and M. Simic 1983) pp. 471–485.
Viaje A. Slaga T. Wigler M. Weinstein I. Cancer Res. 37:1530–1536; 1977.
Kensler T. Bush D. Kozumbo W. Science 221:75–77 1983.
See in Oxy-radicals in Molecular Biology and Pathology, (Eds. P. Cerutli I. Fridovich and J. McCord) New York Alan R. Liss 1988).
D. Crawford P. Amstad D. Yin Foo and P. Cerutti Carcinogenesis 2:136–143 1989.
P. Amstad A. Peskin G. Shah M.E. Mirault R. Moret I. Zbinden and P. Cerutti Biochemistry 9305–9313, 1991.
O. Cantoni P. Sestili F. Cattabeni G. Bellomo S. Pou M. Cohen and P. Cerutti Eur. J. Biochem. 182:209–212 1989.
D. Crawford I. Zbinden P. Amstad and P. Cerutti Oncogene 3:27–32 1988.
M. Shibanuma T. Kuroki and K. Nose Oncogene 3:17–21 1988.
See e.g. P. Herrlich H. Ponta B. Stein C. Jonat S. Gobel, H. Konig R. Williams V. Ivanov and H. Rahmsdorf Transcription factors in normal and malignant cells In Molecular Biology of Cancer Genes (Eds M. Sluyser Ellis Howard Series) in Biomedicine Amsterdam 1990) pp. 150–158.
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Cerutti, P., Amstad, P. (1993). Inflammation and Oxidative Stress in Carcinogenesis. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_75
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DOI: https://doi.org/10.1007/978-1-4615-3520-1_75
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