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Nucleosides and Nucleotides as Antitumor and Antiviral Agents

  • Book
  • © 1993

Overview

Editors:
  1. Chung K. Chu

    1. The University of Georgia, Athens, Georgia

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  2. David C. Baker

    1. The University of Tennessee, Knoxville, USA

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-x
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  2. Design of New Types of Antitumor Nucleosides: The Synthesis and Antitumor Activity of 2′-Deoxy-(2′-C-Substituted)Cytidines

    • Akira Matsuda, Atsushi Azuma, Yuki Nakajima, Kenji Takenuki, Akihito Dan, Tomoharu Iino et al.
    Pages 1-22

  3. Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead

    • Hiromichi Tanaka, Hiroyuki Hayakawa, Tadashi Miyasaka
    Pages 23-53

  4. A Synthesis of 2’-Fluoro- and 3’-Fluoro-Substituted Purine Nucleosides via a Direct Approach

    • Krzysztof W. Pankiewicz, Kyoichi A. Watanabe
    Pages 55-71

  5. Allenols Derived from Nucleic Acid Bases — A New Class of Anti-HIV Agents: Chemistry and Biological Activity

    • Jiri Zemlicka
    Pages 73-100

  6. Structure-Activity Relationships Among HIV Inhibitory 4′-Substituted Nucleosides

    • Ernest J. Prisbe, Hans Maag, Julien P. H. Verheyden, Robert M. Rydzewski
    Pages 101-113

  7. Adenosine-Derived 5′-α-Halo Thioether, Sulfoxide, Sulfone, and (5′-Halo)Methylene Analogues. Inhibition of S-Adenosyl-L-Homocysteine Hydrolase

    • Morris J. Robins, Stanislaw F. Wnuk, Khairuzzaman B. Mullah, N. Kent Dalley, Ronald T. Borchardt, Younha Lee et al.
    Pages 115-126

  8. Approaches to Novel Isomeric Nucleosides as Antiviral Agents

    • Vasu Nair
    Pages 127-140

  9. Carbocyclic 7-Deazaguanosine Nucleosides as Antiviral Agents

    • Stewart W. Schneller, Xing Chen, Suhaib M. Siddiqi
    Pages 141-158

  10. L-Ascorbic and D-Isoascorbic Acids: Chiron Sources for 1′,2′ -SECO-Nucleosides/Tides, Phosphonates, and Other Molecules of Biological Interest

    • Elie Abushanab
    Pages 159-175

  11. Synthesis and Anticancer and Antiviral Activity of Certain Pyrimidine Nucleoside Analogues

    • Tai-Shun Lin, Mao-Chin Liu
    Pages 177-201

  12. Structure-Activity Correlations of 2′,3′-Dideoxy- and 2′,3′-Didehydro-2′,3′-Dideoxypyrimidine Nucleosides as Potential Anti-HIV Drugs

    • Mohamed Nasr, Steven R. Turk
    Pages 203-217

  13. Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides

    • J. Warren Beach, Lak S. Jeong, Hea O. Kim, S. Nampalli, K. Shanmuganathan, Chung K. Chu
    Pages 219-243

  14. 5-Substituted Arabinofuranosyluracil Nucleosides as Antiherpesvirus Agents: From araT to BV-araU

    • Haruhiko Machida, Shinji Sakata
    Pages 245-264

  15. Conformational Studies and Anti-HIV Activity of Mono- and Difluorodideoxy Nucleosides

    • Victor E. Marquez, Benjamin B. Lim, Joseph J. Barchi Jr., Marc C. Nicklaus
    Pages 265-284

  16. Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides

    • Patrick Van Roey, Chung K. Chu
    Pages 285-302

  17. Modified Oligoribonucleotides: Synthesis and Preliminary Evaluation of α-RNA

    • Françoise Debart, Carole Chaix, Bernard Rayner, Jean-Louis Imbach
    Pages 303-310

  18. Towards Second-Generation Synthetic Backbones for Antisense Oligonucleosides

    • Yogesh S. Sanghvi, P. Dan Cook
    Pages 311-324

  19. Back Matter

    Pages 325-336
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Keywords

About this book

Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non­ nucleoside has surpassed the potency of AZT in vitro.

Editors and Affiliations

  • The University of Georgia, Athens, Georgia

    Chung K. Chu

  • The University of Tennessee, Knoxville, USA

    David C. Baker

Bibliographic Information

  • Book Title: Nucleosides and Nucleotides as Antitumor and Antiviral Agents

  • Editors: Chung K. Chu, David C. Baker

  • DOI: https://doi.org/10.1007/978-1-4615-2824-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Hardcover ISBN: 978-0-306-44520-0Published: 31 July 1993

  • Softcover ISBN: 978-1-4613-6221-0Published: 21 October 2012

  • eBook ISBN: 978-1-4615-2824-1Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: X, 336

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Pharmacology/Toxicology, Pharmacy, Analytical Chemistry

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