Skip to main content

Modeling Blood Gas Equilibria of Human Blood

  • Chapter
Oxygen Transport to Tissue XV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 345))

  • 22 Accesses

Abstract

Although not always recognized as such, mathematical models of blood gas and acid-base equilibria are widely used, mostly in blood gas apparatus, to calculate the values of quantities that are not measured, such as base excess, standard base excess, oxygen saturation or 2,3-DPG concentration [1, 2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. O. Siggaard-Andersen and M. Siggaard-Andersen, The oxygen status algorithm: a computer program for calculating and displaying pH and blood gas data, Scand. J. Clin. Lab. Invest. 50, Suppl. 203: 29–45 (1990).

    Article  CAS  Google Scholar 

  2. O. Siggaard-Andersen, P. D. Wimberley, N. Fogh-Andersen and I. H. Gothgen, Measured and derived quantities with modern pH and blood gas equipment: calculation algorithms with 54 equations, Scand. J. Clin. Lab. Invest., Suppl. 189: 7–15 (1988).

    Google Scholar 

  3. L. J. Henderson, “Blood: A Study in General Physiology, ”, Yale University Press, New Haven (Conn.) (1928).

    Google Scholar 

  4. R.B. Singer and A.B. Hastings, An improved clinical method for the estimation of disturbances of the acid-base balance of human blood, Medicine 27: 223–42 (1948).

    Article  PubMed  CAS  Google Scholar 

  5. J.W. Severinghaus, Blood gas calculator, J. Appl. Physiol. 21: 1108–16 (1966).

    PubMed  CAS  Google Scholar 

  6. L.J. Thomas Jr., Algorithms for selected blood acid-base and blood gas calculations, J. Appl. Physiol. 33: 154–8 (1972).

    PubMed  Google Scholar 

  7. P. Rispens, J.R. Brunsting, J.P. Zock and W.G. Zijlstra, A modified Singer-Hastings nomogram, J. Appl. Physiol. 34, 377–82 (1973).

    PubMed  CAS  Google Scholar 

  8. R.G. Rya11 and C.J. Story, Equilibrium model of the oxygen association curve of normal human erythrocytes under standardized conditions, Clin. Chem. 29: 1819–22 (1983).

    PubMed  CAS  Google Scholar 

  9. J. Wyman, The binding potential, a neglected linkage concept, J. Molex. Biol. 11: 631–44 (1965).

    Article  CAS  Google Scholar 

  10. J.P. Zock, Mathematical model of the physiological properties of human hemoglobin, Proc. Ken. Ned. Mad. Wet. C90: 493–508 (1987).

    Google Scholar 

  11. J. Wyman and S.J. Gill, “Binding and Linkage,” University Science Books, Mill Valley (1990).

    Google Scholar 

  12. J. P. Zock, Carbon monoxide binding in a model of hemoglobin differs between the T and the R conformation, in: J. Piiper, T.K. Goldstick and M. Meyer(eds), “Oxygen Transport to Tissue XII,” Plenum Press, New York (1990).

    Google Scholar 

  13. P. Rispens, “Significance of Plasma Bicarbonate for the Evaluation of H+ Homeostasis,” Thesis, Groningen (1970).

    Google Scholar 

  14. J. P. Zock, “CO2 and O2 Equilibria in Human Blood and Interstitial Fluid,” Thesis, Groningen (1985).

    Google Scholar 

  15. G. Arthurson, L. Garby, M. Robert and B. Zaar, The oxygen dissociation curve of normal human blood with special reference to the influence of physiological effector ligands, Scam/. J. Clin. Lab. Invest. 34: 9–13 (1974).

    Article  Google Scholar 

  16. A. Zwart, “Spectral and Functional Properties of Haemoglobin in Human Whole Blood,” Thesis, Groningen (1983).

    Google Scholar 

  17. L. Garhy and J. Meldon, “The Respiratory Functions of Blood,” Plenum Press, New York (1977).

    Google Scholar 

  18. Groth, L. Clarity and C.H. de Verdier, Estimation of parameters in a multi-affinity-state model for haemoglobin from oxygen binding data in whole blood and in concentrated haemoglobin solutions, J. Motec. Biol. 121: 507–22 (1978).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Zock, J.P. (1994). Modeling Blood Gas Equilibria of Human Blood. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2468-7_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6051-3

  • Online ISBN: 978-1-4615-2468-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics