Abstract
Genes involved in the regulation of key cellular pathways have been, through strong evolutionary pressure, well-conserved. As a consequence, genes often harbour well-conserved domains evolved from duplication and recombination events. This process has led to the multiplication and diversification of basic functional units. This principle has been repeatedly confirmed by the isolation of multigene families whose significance transverses the species barrier (Beato, 1989; Bopp et al., 1986; Frigerio et al., 1986; Kessel and Gruss, 1990; Rosenfeld, 1991; Schubert et al., 1993).
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Tremblay, P., Dietrich, S., Stoykova, A., Stuart, E.T., Gruss, P. (1995). Pax Genes as Pleiotropic Regulators of Embryonic Development. In: Juurlink, B.H.J., Krone, P.H., Kulyk, W.M., Verge, V.M.K., Doucette, J.R. (eds) Neural Cell Specification. Altschul Symposia Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1929-4_3
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