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Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

  • Book
  • © 1995

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Editors:
  1. Ben Avi Weissman

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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  2. Nahum Allon

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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  3. Shlomo Shapira

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xi
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  2. The Nitric Oxide Signal Transduction System

    1. The Nitric Oxide Signal Transduction System

      • Ferid Murad
      Pages 1-11

  3. Chemistry and Biochemistry of Nitric Oxide

    1. Mechanisms of Mammalian Nitric Oxide Biosynthesis

      • Paul L. Feldman, Dennis J. Stuehr, Owen W. Griffith, Jon M. Fukuto
      Pages 13-20

    2. Nitric Oxide Synthase Inhibitors: Mechanism of Action and in Vivo Studies

      • Owen W. Griffith
      Pages 21-36

    3. Biosynthesis of Nitric Oxide

      • Bernd Mayer
      Pages 37-48

    4. Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications

      • Markus Hecker, Ingrid Fleming, Kazuhide Ayajiki, Rudi Busse
      Pages 49-56

    5. Determination of Nitric Oxide Levels by Fluorescence Spectroscopy

      • G. Gabor, N. Allon
      Pages 57-66

  4. Pharmacology and Drug Development

    1. S-Nitrosothiols: Correlation of Biological Chemistry with Physiological Actions

      • Jonathan S. Stamler
      Pages 67-78

    2. Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin 1 in the Treatment of Patients with Erectile Dysfunction

      • Michael C. Truss, Armin J. Becker, Christian G. Stief, Udo Jonas
      Pages 79-83

    3. Nitric Oxide-Induced Lymphocyte Activation: A Role for G Proteins

      • Harry M. Lander, Roberto Levi, Abraham Novogrodsky
      Pages 85-91

    4. Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog

      • Jacques Mizrahi, Robert J. Bache, Eberhard Bassenge, Alain Berdeaux, Jean-Francois Giudicelli, Akira Ueno et al.
      Pages 93-101

    5. Nitric Oxide in Amphibian Photoreceptors

      • Karl-F. Schmidt, Gottfried N. Nöll
      Pages 103-110

    6. The Involvement of L-Arginine-Nitric Oxide Pathway in the Anti-Rickettsial Activity of Macrophagelike Cells

      • Avi Keysary, Chaya Oron, Miri Rosner, Ben Avi Weissman
      Pages 111-115

    7. Modulation of LDL and oxy-LDL Catabolism by No-Donors and PGE2 in Human Peripheral Blood Lymphocytes and Rat Macrophages

      • Aldona Dembinska-Kiec, Iwona Wybranska, Barbara Miszczuk-Jamska, Ewa Baczynska, Jadwiga Hartwich, Pawel Goldsztajn
      Pages 117-122

  5. Nitric Oxide and the Respiratory and Cardiovascular Systems

    1. The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth Muscle

      • Louis Diamond, Ralph J. Altiere, Greg Lindsay, David C. Thompson
      Pages 123-130

    2. Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles

      • Nahum Allon, Yaakov Meshulam
      Pages 131-136

    3. Comparative Effects of Nω-Nitro-L-Arginine, Nω-Nitro-L-Arginine Methyl Ester, and Nω-Nitro-L-Arginine Benzyl Ester on Vasodilator Responses to Acetylcholine and Substance P

      • David Y. Cheng, Bracken J. DeWitt, Timothy J. McMahon, Jose A. Santiago, Dennis B. McNamara, Philip J. Kadowitz
      Pages 137-144

    4. Vascular Responses to Endothelin-1 in Conscious Rats: Modulation by Endogenous Nitric Oxide

      • Janos G. Filep, Alain Fournier, Eva Foldes-Filep
      Pages 145-152

    5. Stimulation of Endogenous No-Production Influences the Dilation of the Capillary Microvasculature in Vivo

      • Wilhelm Bloch, Dirk Hoever, Klaus Addicks
      Pages 153-160

    6. Induction of Nadph — Diaphorase — Activity with Endotoxin in Rat Heart and Spleen in Vivo

      • W. Bloch, G. Dickneite, A. Krahwinkel, F. Dobers, K. Addicks
      Pages 161-165
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Keywords

About this book

A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology­ minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e. , cyclic AMP), participate in a diverse set of functions.

Editors and Affiliations

  • Israel Institute for Biological Research, Ness-Ziona, Israel

    Ben Avi Weissman, Nahum Allon, Shlomo Shapira

Bibliographic Information

  • Book Title: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

  • Editors: Ben Avi Weissman, Nahum Allon, Shlomo Shapira

  • DOI: https://doi.org/10.1007/978-1-4615-1903-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1995

  • Hardcover ISBN: 978-0-306-45113-3Published: 31 October 1995

  • Softcover ISBN: 978-1-4613-5777-3Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1903-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 248

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Animal Physiology, Biological and Medical Physics, Biophysics

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