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Endothelial Cell Regulation of Coagulation

  • Chapter
The Molecular and Cellular Biology of Wound Repair

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Abstract

The cessation of hemorrhage around wounded tissue and isolation of pathologic processes, such as an infection or solid neoplasias, are mediated in part by thrombus formation and occlusion of blood vessel lumina. The clinical outcome of blood vessel occlusion may be quite devastating in certain processes, such as myocardial infarction or vasculitis. Nevertheless, thrombotic phenomena are ubiquitous and closely linked to the body’s response to injury (Dvoarak, 1980, 1984, 1985). The limitation of clot formation to inflamed or injured tissue suggests that the coagulation is under local regulation and therefore involves more than plasma protein-protein interactions. Thus, local cell mediators may play a central role in the regulation of procoagulant events. The ideal characteristics of these mediators would include high efficiency when inducing intravascular coagulation following stimulation, balanced by little or no activity in the quiescent state.

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Authors and Affiliations

  1. Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, USA

    David M. Stern & Peter P. Nawroth

  2. Division of Platelet Research, Sandoz Inc., East Hanover, New Jersey, 07936, USA

    Dean Handley

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Editors and Affiliations

  1. National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA

    R. A. F. Clark  & P. M. Henson  & 

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Stern, D.M., Handley, D., Nawroth, P.P. (1998). Endothelial Cell Regulation of Coagulation. In: Clark, R.A.F., Henson, P.M. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1795-5_4

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