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Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing

  • Chapter
Neuropathology and Genetics of Dementia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 487))

Abstract

In eukaryotic cells, mitochondria are the organelles that produce the majority of adenosine triphosphate (ATP) required for normal neuronal function and survival. ATP is generated by oxidative phosphorylation (OXPHOS) within mitochondria from intermediates, such as NADH and FADH2which are produced by ß-oxidation and the Kreb’s cycle.

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Authors and Affiliations

  1. University Department of Clinical Neurosciences, Royal Free and University College Medical School and lnstitute of Neurology University College London, London NW3 2PF, UK

    Christopher Turner & Anthony H. V. Schapira

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  1. Christopher Turner
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  2. Anthony H. V. Schapira
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  1. University of Basel, Basel, Switzerland

    Markus Tolnay  & Alphonse Probst  & 

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Turner, C., Schapira, A.H.V. (2001). Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing. In: Tolnay, M., Probst, A. (eds) Neuropathology and Genetics of Dementia. Advances in Experimental Medicine and Biology, vol 487. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1249-3_19

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  • DOI: https://doi.org/10.1007/978-1-4615-1249-3_19

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  • Print ISBN: 978-1-4613-5461-1

  • Online ISBN: 978-1-4615-1249-3

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