Abstract
Our previous research has indicated that androgen deficiency may be a critical etiologic factor in the pathogenesis of meibomian gland dysfunction, tear film instability and evaporative dry eye.1–3 We hypothesize that this may be due, at least in part, to significant alterations in the lipid profile of meibomian gland secretions.3 To test this hypothesis, we examined whether androgen deficiency, such as that occurring during aging in both sexes, complete androgen insensitivity syndrome (CAIS), the use of anti-androgen therapy and Sjögren’s syndrome (SS),4–7 is associated with significant changes in the fatty acid (FA) patterns of neutral and polar lipids in meibomian gland secretions. In addition, we determined whether lipid profiles could be used to separate individuals into clinically identifiable groups.
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Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR, Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls BD, Toda I. Androgens and dry eye in Sjögren’s syndrome. Ann NY Acad Sci. 1999;876:312–324.
Krenzer KL, Dana MR, Ullman MD, Cermak JM, Tolls BD, Evans JE, Sullivan DA. Effect of androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocr Metab. 2000;85:4874–4882.
Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Impact of anti-androgen treatment on the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocr Metab. 2000;85:4866–4873.
Labrie F, Belanger A, Cusan L, Gomez JL, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocr Metab. 1997;82:2396–2402.
Zhu YS, Cai LQ, Cordero JJ, Canovatchel WJ, Katz MD, Imperato-McGinley J. A novel mutation in the CAG triplet region of exon 1 of androgen receptor gene causes complete androgen insensitivity syndrome in a large kindred. J Clin Endocrinol Metab. 1999;84:1590–1594.
Sullivan DA. Sex hormones and Sjögren’s syndrome. J Rheumatol. 1997;24 (Suppl 50): 17–32.
Sullivan DA, Bélanger A, Cermak JM, Papas AS, Sullivan RM, Yamagami H, Dana MR, Labrie F. Are women with Sjögren’s syndrome androgen deficient? Invest Ophthalmol Vis Sci. 2000;Suppl. 41:S276. 1999 Physicians’ Desk Reference. 53rd ed. Montvale, NJ: Medical Economics Co.
Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Complete androgen insensitivity syndrome: influence on the polar and neutral lipid profiles of human meibomian gland secretions. Manuscript submitted, 2001.
Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Effect of aging on lipid patterns in human meibomian gland secretions. Manuscript submitted, 2001.
Sullivan BD, Evans JE, Sullivan RM, Schaumberg DA, Dana MR, Sullivan DA. Impact of hormone replacement therapy on the lipid profile of meibomian gland secretions in postmenopausal women. Manuscript submitted, 2001.
Labrie F, Bélanger A, Simard J, Luu-The V, Labrie C. DHEA and peripheral androgen and estrogen formation: intracrinology. Ann NY Acad Sci. 1995;774:16–28.
Yamagami H, Richards SM, Sullivan BD, Liu M, Steagall RJ, Sullivan DA. Gender-associated differences in gene expression of the meibomian gland. Adv Exp Med Biol. 2001 ; in press.
Chew CKS, Hykin PG, Janswijer C, Dikstein S, Tiffany JM, Bron AJ. The casual level of meibomian lipids in humans. Curr Eye Res. 1993;12:255–259.
Shine WE, McCulley JP. The role of cholesterol in chronic blepharitis. Invest Ophthalmol Vis Sci. 1991;32:2272–2280.
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Sullivan, B.D., Evans, J.E., Dana, M.R., Sullivan, D.A. (2002). Impact of Androgen Deficiency on the Lipid Profiles in Human Meibomian Gland Secretions. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_63
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_63
Publisher Name: Springer, Boston, MA
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