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Endothelial Nitric Oxide Synthase in Cardiovascular Homeostasis and Disease

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The Physiological Genomics of the Critically Ill Mouse

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 16))

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Abstract

In 1980, Furchgott and Zawadzki22 demonstrated the pivotal importance of the endothelium for mediating vasodilator responses to substances such as acetylcholine. The authors proposed that a substance derived from the endothelium mediated these vasodilator responses and termed it endothelium derived relaxing factor (EDRF). In 1987 it was subsequently shown that EDRF most likely is nitric oxide (NO) or a nitrosothiol compound29’S3 NO is produced by NO synthases (NOS) via a reaction in which L-arginine is converted to L-citrulline47. There are currently three known NOS enzymes in mammals: neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS). The enzymes and the genes encoding the enzymes are also termed NOS 1 (nNOS), NOS2 (iNOS) and NOS3 (eNOS)41’47.

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Authors and Affiliations

  1. Division of Experimental Cardiology, Cardiology, Thoraxcenter, Rotterdam, the Netherlands

    Dirk J. Duncker, Elza van Deel & Monique de Waard

  2. Division of Experimental Cardiology, Cardiology, Thoraxcenter and Vascular Surgery, Rotterdam, the Netherlands

    Rien van Haperen, Barend Mees & Rini de Crom

  3. Division of Experimental Cardiology, Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

    Rini de Crom

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  1. Dirk J. Duncker
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  1. Department of Physiology Academic Medical Center, University of Amsterdam, The Netherlands

    Can Ince

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Duncker, D.J., van Haperen, R., van Deel, E., de Waard, M., Mees, B., de Crom, R. (2004). Endothelial Nitric Oxide Synthase in Cardiovascular Homeostasis and Disease. In: Ince, C. (eds) The Physiological Genomics of the Critically Ill Mouse. Basic Science for the Cardiologist, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0483-2_21

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