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Encyclopedia of Medical Immunology pp 514Cite as

Nitroglycerin Dermatitis

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Synonyms

Contact dermatitis; Nitroglycerin

Glyceryl trinitrate (nitroglycerin) can be topically applied as a patch to induce systemic vasodilatation or an ointment around the anus to relax the muscle tonus of the sphincter ani and thus relief the pain due to anal fissures. While delayed-type hypersensitivity sensitization to nitroglycerin is not a common event, it can be the cause of chronic anal eczema, which often is misdiagnosed due to other potential trigger factors such as localized microbial infection or chronic irritation of the fissure. Patch testing will reveal the allergic reaction.

Cross-References

Allergic Contact Dermatitis

Contact Dermatitis Due to Topical Drugs

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany

    Wolfgang Pfützner

Authors
  1. Wolfgang Pfützner
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Correspondence to Wolfgang Pfützner .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Dennis K. Ledford

  4. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Richard F. Lockey

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© 2014 Springer-Verlag Berlin Heidelberg

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Pfützner, W. (2014). Nitroglycerin Dermatitis. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_474

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  • DOI: https://doi.org/10.1007/978-1-4614-9194-1_474

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9193-4

  • Online ISBN: 978-1-4614-9194-1

  • eBook Packages: MedicineReference Module Medicine

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