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Fundamentals of Pharmaceutical Nanoscience pp 91–116Cite as

Solid Lipid Nanoparticles (SLN™)

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Abstract

Solid lipid nanoparticles (SLN™) are a new generation of drug delivery systems being exploited for several drugs since the nineties. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. In the present chapter, the chemical structure, production methodology, and physicochemical characterization are systematically discussed. Parameters such as particle size, distribution, polymorphic behaviour, and crystallization are required to characterize SLN and may predict their in vitro stability and in vivo profile, therefore structural parameters can influence the biopharmaceutical properties. The use of SLN for drug delivery is also dependent on their toxicological profile in vitro. Nanotoxicology is also discussed addressing the key points that may limit the clinical use of SLN.

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Authors and Affiliations

  1. Institute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro (CGB-UTAD/IBB), Vila Real, Portugal

    Eliana B. Souto

  2. Faculty of Health Sciences, Fernando Pessoa University (FCS-UFP), Porto, Portugal

    Eliana B. Souto & Joana F. Fangueiro

  3. Department of Pharmacy, Pharmaceutical Technology, Biopharmaceutics & NutriCosmetics, Freie Universität Berlin, Berlin, Germany

    Rainer H. Müller

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  1. Eliana B. Souto
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  2. Joana F. Fangueiro
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  3. Rainer H. Müller
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Correspondence to Eliana B. Souto .

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Editors and Affiliations

  1. UCL School of Pharmacy, University College London, London, United Kingdom

    Ijeoma F. Uchegbu

  2. UCL School of Pharmacy, University College London, London, United Kingdom

    Andreas G. Schätzlein

  3. Bexleyheath, United Kingdom

    Woei Ping Cheng

  4. School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom

    Aikaterini Lalatsa

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© 2013 Springer Science+Business Media New York

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Souto, E.B., Fangueiro, J.F., Müller, R.H. (2013). Solid Lipid Nanoparticles (SLN™). In: Uchegbu, I., Schätzlein, A., Cheng, W., Lalatsa, A. (eds) Fundamentals of Pharmaceutical Nanoscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9164-4_5

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