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Nanomedicines for Nervous System Diseases

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Handbook of Neurotoxicity

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Abstract

The need for the development of nanomedicines for the treatment of degenerative and inflammatory diseases of the nervous system is of immediate importance. Nanoparticles are drug carriers that can specifically target diseased brain subregions and thus enhance therapeutic efficacy. Multifunctional nanoparticles delivering pharmaceutical agents serve a dual purpose: While they facilitate drug delivery they also provide imaging of cell dynamics and pharmacokinetic assessments. Polymer science and nanotechnology could be used to improve diagnostic and therapeutic outcomes. Despite their promise in combating disease, nanomedicines have yet to make their mark as broadly viable pharmaceuticals. The translation of nanoformulation technology for clinical therapeutic and diagnostic applications shows both real potential and inherent obstacles. However, safety concerns remain operative for their potential broad clinical implications, tempering any translational potential.

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Acknowledgments

The work was supported by the National Institutes of Health grants 1P01 DA028555, 2R01 NS034239, 2R37 NS36126, P01 NS31492, P20RR 15635, P01MH64570, and P01 NS43985.

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Authors and Affiliations

  1. Departments of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA

    Dongwei Guo

  2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198-5880, USA

    JoEllyn M. McMillan & Howard E. Gendelman

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  1. Dongwei Guo
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  2. JoEllyn M. McMillan
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  3. Howard E. Gendelman
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Correspondence to Howard E. Gendelman .

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  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA

    Richard M. Kostrzewa

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Guo, D., McMillan, J.M., Gendelman, H.E. (2014). Nanomedicines for Nervous System Diseases. In: Kostrzewa, R. (eds) Handbook of Neurotoxicity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5836-4_116

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