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Neural Tissue Engineering

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Neural Engineering

Abstract

Injury to the nervous system leads to several debilitating long-term disabilities that can severely impair quality of life. Regenerative failure following injury is the primary cause of disability and is mainly attributed to the localized upregulation of nerve inhibitory molecules in the case of central nervous system (CNS) injuries, and the presence of inhibitory molecules along with the absence of structural support in the case of peripheral nervous system (PNS) injuries. While treatments using autografts and allografts do result in appreciable nerve regeneration in the case of peripheral nerve gaps, the same is not true of CNS injuries which are difficult to treat.

This chapter discusses innate differences and challenges in treating CNS and PNS injuries, and the current methodologies being employed to enhance the endogenous regenerative potential and plasticity. The state-of-the-art in facilitating repair and rehabilitation by means of biochemical and cellular therapies as well as by electrical stimulation of neuromuscular tissue are also discussed.

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    Lohitash Karumbaiah & Ravi Bellamkonda

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    Bin He

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Karumbaiah, L., Bellamkonda, R. (2013). Neural Tissue Engineering. In: He, B. (eds) Neural Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-5227-0_19

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